Thymopentin
![Thymopentin Structure](CAS/GIF/69558-55-0.gif)
- CAS No.
- 69558-55-0
- Chemical Name:
- Thymopentin
- Synonyms
- TP-5;RKDVY;Immunox;Timunox;ORF-15244;THYMOPETIN;Thyopentin;THYMOPENTIN;Thymopentine;ThymopentinⅡ
- CBNumber:
- CB7491069
- Molecular Formula:
- C30H49N9O9
- Molecular Weight:
- 679.77
- MOL File:
- 69558-55-0.mol
- Modify Date:
- 2024/7/10 17:45:06
Density | 1.44±0.1 g/cm3(Predicted) |
---|---|
storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
solubility | DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 10 mg/ml |
form | Powder |
pka | 3.07±0.10(Predicted) |
color | White |
CAS DataBase Reference | 69558-55-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302 | |||||||||
Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
WGK Germany | 3 | |||||||||
HS Code | 3504009000 | |||||||||
NFPA 704 |
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Thymopentin Chemical Properties,Uses,Production
Description
Thymopentin is a kind of peptide. Peptides and polypeptides play a critical role in the immune system and are therefore predestined as a source for new approaches in immunotherapy. Thymopentin is capable of modulating the immune response. It is a fragment of the thymopoietins (TMPOs) which is a family of nuclear protein. Studies have shown that Thymopentin is capable of affecting the function of T cells and monocytes monitored by increased cGMP level and the triggering of cellular signaling. It is also capable of improve an imbalanced immune system. As an immunomodulating agent, it is clinically used in the treatment of autoimmune diseases such as atopic dermatitis, chronic lymphocytic leukemia, Sezary’s syndrome, rheumatoid arthritis and decreased immune competency. Recent study has also shown that its immuno-modulating effect can also help fight against the infection of mycobacterium tuberculosis.
Uses
Thymopentin Acetate (TP-5) is a synthetic immunomodulating pentapeptide.
Clinical Use
Thymopentin is a synthetic, immunomodulating pentapeptide, representing the active fragment of the thymus hormone, thymopoietin. Thymopentin induces phenotypic differentiation and maturation of T-cells. It appears of value in the treatment of primary immune deficiency, rheumatoid arthritis, atopic dermatitis, sarcoidosis and a variety of other diseases with manifestations of disturbed immune balance.
References
Zhang, Yan, et al. "Novel thymopentin release systems prepared from bioresorbable PLA–PEG–PLA hydrogels." International journal of pharmaceutics 386.1 (2010): 15-22.
Gonser, S., E. Weber, and G. Folkers. "Peptides and polypeptides as modulators of the immune response: thymopentin—an example with unknown mode of action." Pharmaceutica Acta Helvetiae 73.6 (1999): 265-273.
Wang, Ying, et al. "Synthetic modifications of the immunomodulating peptide thymopentin to confer anti-mycobacterial activity." Biomaterials 35.9 (2014): 3102-3109.
Thymopentin Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
Wuhan Haorong Biotechnology Co.,ltd | +86-18565342920; +8618565342920 | China | 289 | 58 | Inquiry |
Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | China | 616 | 58 | Inquiry |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | China | 16920 | 58 | Inquiry |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21669 | 55 | Inquiry |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29896 | 58 | Inquiry |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | China | 10312 | 58 | Inquiry |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |