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Thymopentin

Thymopentin Structure
CAS No.
69558-55-0
Chemical Name:
Thymopentin
Synonyms
TP-5;RKDVY;Immunox;Timunox;ORF-15244;THYMOPETIN;Thyopentin;THYMOPENTIN;Thymopentine;ThymopentinⅡ
CBNumber:
CB7491069
Molecular Formula:
C30H49N9O9
Molecular Weight:
679.77
MOL File:
69558-55-0.mol
Modify Date:
2024/7/10 17:45:06

Thymopentin Properties

Density 1.44±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 10 mg/ml
form Powder
pka 3.07±0.10(Predicted)
color White
CAS DataBase Reference 69558-55-0(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
WGK Germany  3
HS Code  3504009000
NFPA 704
0
2 0

Thymopentin price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) T8806 Thymopentin ≥97% (HPLC) 69558-55-0 10MG ₹13131.3 2022-06-14 Buy
Product number Packaging Price Buy
T8806 10MG ₹13131.3 Buy

Thymopentin Chemical Properties,Uses,Production

Description

Thymopentin is a kind of peptide. Peptides and polypeptides play a critical role in the immune system and are therefore predestined as a source for new approaches in immunotherapy. Thymopentin is capable of modulating the immune response. It is a fragment of the thymopoietins (TMPOs) which is a family of nuclear protein. Studies have shown that Thymopentin is capable of affecting the function of T cells and monocytes monitored by increased cGMP level and the triggering of cellular signaling. It is also capable of improve an imbalanced immune system. As an immunomodulating agent, it is clinically used in the treatment of autoimmune diseases such as atopic dermatitis, chronic lymphocytic leukemia, Sezary’s syndrome, rheumatoid arthritis and decreased immune competency. Recent study has also shown that its immuno-modulating effect can also help fight against the infection of mycobacterium tuberculosis.

Uses

Thymopentin Acetate (TP-5) is a synthetic immunomodulating pentapeptide.

Clinical Use

Thymopentin is a synthetic, immunomodulating pentapeptide, representing the active fragment of the thymus hormone, thymopoietin. Thymopentin induces phenotypic differentiation and maturation of T-cells. It appears of value in the treatment of primary immune deficiency, rheumatoid arthritis, atopic dermatitis, sarcoidosis and a variety of other diseases with manifestations of disturbed immune balance.

References

Zhang, Yan, et al. "Novel thymopentin release systems prepared from bioresorbable PLA–PEG–PLA hydrogels." International journal of pharmaceutics 386.1 (2010): 15-22.
Gonser, S., E. Weber, and G. Folkers. "Peptides and polypeptides as modulators of the immune response: thymopentin—an example with unknown mode of action." Pharmaceutica Acta Helvetiae 73.6 (1999): 265-273.
Wang, Ying, et al. "Synthetic modifications of the immunomodulating peptide thymopentin to confer anti-mycobacterial activity." Biomaterials 35.9 (2014): 3102-3109.

Thymopentin Preparation Products And Raw materials

Raw materials

Preparation Products

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32-36-Thymopoietin L-Arg-L-Lys-L-Asp-L-Val-L-Tyr-OH Thymopoietin II-(32-36) ThyMopentin for Injection TP-5 THYMOPENTIN THYMOPENTIN 5 THYMOPOIETIN (32-36) (HUMAN, MOUSE) THYMOPOIETIN II FRAGMENT (32-36) THYMOPOIETIN I/II (32-36) (BOVINE) THYMOPOIETIN PENTAPEPTIDE Immunox Sintomodulina Thymopentin-FITC Thymopoietin 32-36 Timunox ARG-LYS-ASP-VAL-TYR (ASP34)-THYMOPOIETIN III (32-36) (BOVINE) H-ARG-LYS-ASP-VAL-TYR-OH RKDVY TP-5(Thymopentin) Thymopentin TP-5 Thymopentine THYMOPETIN Arg-Lys-Asp-Val-Tyr-OH Thymopoietin pentapeptide-Fluorescin-isothiocyanate thymopentin pentapeptide Thyopentin Thymopent njection ThymopentinⅡ Sibuxintramine TP-5 / Thymopentin GMP (CFDA) CAS L-Tyrosine, L-arginyl-L-lysyl-L-α-aspartyl-L-valyl- (6S,9S,12S,15S,18S)-1,6-Diamino-9-(4-aminobutyl)-12-(carboxymethyl)-18-(4-hydroxybenzyl)-1-imino-15-isopropyl-7,10,13,16-tetraoxo-2,8,11,14,17-pentaazanonadecan-19-oic acid Thymopentin USP/EP/BP NH2-RKDVY-OH 69558-55-0 Thymopentin Thymopeptide ORF 15244 ORF15244 ORF-15244 TP 5 Thymopoietin pentapeptide 69558-55-0 9558-55-0 C30H49N9O9 C265H397O67N73 BioChemical Amino Acids and Peptides Biochemicals and Reagents Peptides Other Peptides 多肽 Inhibitors IMMUNOX Peptide Amino Acid Derivatives