42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin

42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin Structure
CAS No.
143030-02-8
Chemical Name:
42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin
Synonyms
Rapamycin Impurity 32;42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin;Rapamycin, 42-O-[(1,1-dimethylethyl)dimethylsilyl]-;Clobetasone Butyrate Impurity 9 (Clobetasone Butyrate EP Impurity I)
CBNumber:
CB75177306
Molecular Formula:
C57H93NO13Si
Molecular Weight:
1028.45
MOL File:
143030-02-8.mol
Modify Date:
2023/4/23 13:52:06

42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin Properties

Boiling point 977.0±75.0 °C(Predicted)
Density 1.12±0.1 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility Dichloromethane, Methanol
form Solid
pka 10.40±0.70(Predicted)
color White

42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin Chemical Properties,Uses,Production

Uses

42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin is an intermediate in the synthesis of 8-O-Methyl-rapamycin which is a derivative of Rapamycin (R124000), a triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, Rapa’Nui. Used as an immunosuppressant; antirestenotic. Sirolimus (INN/USAN), also known as rapamycin, is an immunosuppressant drug used to prevent rejection in organ transplantation; it is especially useful in kidney transplants.

42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin Preparation Products And Raw materials

Raw materials

Preparation Products

42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin Suppliers

Global( 8)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
United States Biological 1-800-520-3011 United States 6106 58 Inquiry
Shanghai Hao Zhun Biological Technology Co., Ltd. 15800340161 CHINA 6846 58 Inquiry
Shandong Wadesen Biotechnology Co. LTD 0531-88723173 18596073690 China 3946 58 Inquiry
guoyungurui 18162595016 China 10337 58 Inquiry
Hubei Xinyang Medical Technology Co., Ltd 15347293736 15347293736 China 8287 58 Inquiry
Nanning Saifir Biotechnology Co., Ltd. 18877121284 China 259 58 Inquiry
Wuhan Acumen Bio-Technology Co.,ltd 027-027-16602739303 16602739303 China 3075 58 Inquiry
42-O-[(1,1-Dimethylethyl)dimethylsilyl]rapamycin Rapamycin Impurity 32 Rapamycin, 42-O-[(1,1-dimethylethyl)dimethylsilyl]- Clobetasone Butyrate Impurity 9 (Clobetasone Butyrate EP Impurity I) 143030-02-8