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ChemicalBook > Product Catalog >Organic Chemistry >Carboxylic acids and derivatives >4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester

4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester

4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Structure
CAS No.
206989-61-9
Chemical Name:
4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester
Synonyms
tert-Butyl 4-acetylpiperidine-1-carboxylate;1-Boc-4-acetyL;N-Boc-4-Acetypiperidine;Zanubrutinib Impurity 6;N-Boc-4-acetylpiperidine;Zanubrutinib impurity-22;1-BOC-4-ACETYL-PIPERIDINE;-N-Boc-4-Acetylpiperidine;1-N-Boc-4-Acetylpiperidine;1-BOC-ESTER4-ACETYL-PIPERIDINE
CBNumber:
CB7704363
Molecular Formula:
C12H21NO3
Molecular Weight:
227.3
MOL File:
206989-61-9.mol
MSDS File:
SDS
Modify Date:
2024/3/8 16:13:53
Request For Quotation

4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Properties

Boiling point 312.4±35.0 °C(Predicted)
Density 1.052±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
pka -2.23±0.40(Predicted)
InChI InChI=1S/C12H21NO3/c1-9(14)10-5-7-13(8-6-10)11(15)16-12(2,3)4/h10H,5-8H2,1-4H3
InChIKey HNVBBNZWMSTMAZ-UHFFFAOYSA-N
SMILES N1(C(OC(C)(C)C)=O)CCC(C(C)=O)CC1

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310
Hazard Codes  T
Risk Statements  25
Safety Statements  45
RIDADR  UN 2811 6.1 / PGIII
HazardClass  IRRITANT
HS Code  2933399990

4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SYX00409 tert-Butyl 4-acetylpiperidine-1-carboxylate 206989-61-9 1G ₹41860.28 2022-06-14 Buy
Product number Packaging Price Buy
SYX00409 1G ₹41860.28 Buy

4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Chemical Properties,Uses,Production

Uses

tert-Butyl 4-Acetylpiperidine-1-carboxylate is a useful research chemical.

Synthesis

Tert-butyl-4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate (2.29 g, 8.32 mmol) was dissolved in 30 ml of tetrahydrofuran (THF), and the resulting solution was cooled to -78 °C. To the solution, methylmagnesium bromide (3.0 M) (7.73 ml, 10.82 mmol) was slowly added, and the solution was stirred at 0 °C for 1 hr. After the reaction was completed with a 2 N hydrochloric acid aqueous solution, 6 N sodium hydroxide solution was added to adjust the pH to 10. Then the solution was extracted with dichloromethane. The organic layer was treated with magnesium sulfate (MgSO4) and filtered, and the solution was concentrated. The resulting residue was isolated and purified by silica gel column chromatography (dichloromethane/methanol = 10/1) to give 4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester (6.36 g, 94.0 percent).

4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

4-(2-ETHOXYCARBONYL-ACETYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-Boc-4-[methoxy(methyl)carbamoyl]piperidine Methylmagnesium Bromide

Preparation Products

2-bromo-1-(1-Boc-piperidin-4-yl)ethanone TERT-BUTYL 4-(1-AMINOETHYL)PIPERIDINE-1-CARBOXYLATE tert-butyl 4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidine-1-carboxylate

4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Suppliers

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ARRKEM LIFE SCIENCES PRIVATE LIMITED 58
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REDDY N REDDY PHARMACEUTICALS 58
CHEMAZON LABORATORIES 58
A.J Chemicals 58
SynZeal Research Pvt Ltd 58
Shanxi Tihondan Pharmaceutical Technology Co., Ltd 58

4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Spectrum

4-ACETYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(206989-61-9)1HNMR4-ACETYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(206989-61-9)FT-IR

206989-61-9(4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester)Related Search:

1-Piperidinecarboxylic acid, 4-[3-(dimethylamino)-1-oxo-2-propen-1-yl]-, 1,1-dim Propanedinitrile, 2-[hydroxy(4-phenoxyphenyl)Methylene]- Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]- tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate 5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile
tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 4,5,6,7-tetrahydro-2-(4-phenoxyphenyl)-7-(4-piperidinyl)-, (7S)- (R)-Zanubrutinib 4-PHENOXYBENZOIC ACID Pyrazolo[1,5-a]pyrimidine-3-carbonitrile, 4,5,6,7-tetrahydro-2-(4-phenoxyphenyl)-7-(4-piperidinyl)-
Zanubrutinib 1-Boc-hexahydro-1H-azepin-4-amine 1-Boc-4-cyanopiperidine 3-AMINO-1-[(1,1-DIMETHYLETHOXY)CARBONYL]-3-PIPERIDINEACETIC ACID METHYL ESTER tert-butyl 6-hydroxy-3-azabicyclo[3.1.0]hexane-3-carboxylate
tert-butyl 4-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate tert-Butyl 3,8-diazabicyclo[3.2.1]octane-8-carboxylate hydrochloride 2-OXO-2,5-DIHYDRO-PYRROLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
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4-ACETYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-N-Boc-4-Acetylpiperidine N-Boc-4-acetylpiperidine 1-tert-Butoxycarbonyl-4-acetylpiperidine 1-Piperidinecarboxylic acid, 4-acetyl-, 1,1-dimethylethyl ester 1-BOC-4-ACETYL-PIPERIDINE N-Boc-4-Acetypiperidine 1-BOC-ESTER4-ACETYL-PIPERIDINE 4-acetyl-piperidine-1-carboxylic acid Mono t-butyl ester 4-acetyl-1-piperidinecarboxylic acid tert-butyl ester tert-butyl 4-ethanoylpiperidine-1-carboxylate 4-acetyl-1-(t-butoxycarbonyl)piperidine 1-Boc-4-acetyL Zanubrutinib Related Compound 4 Zanubrutinib Impurity 6 -N-Boc-4-Acetylpiperidine tert-Butyl 4-acetylpiperidine-1-carboxylate 7-(1-benzoylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide Zanubrutinib benzoyl amide impurity Zanubrutinib impurity-22 206989-61-9 206979-61-9 C12H20NO4