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ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile

5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile

5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile Structure
CAS No.
330792-70-6
Chemical Name:
5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile
Synonyms
IbrutinibN-3;IbrutinibIntermediate4;Ibrutinib intermediate3;Zanubrutinib Impurity 8;Zanubrutinib impurity-20;Ibrutinib intermediates N-3;Zanubrutinib Related Compound 6;3-AMino-4-cyano-5-(4-phenoxyphenyl)pyrazole;3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile;3-amino-5-(4-phenoxyphenyl)-1H-Pyrazole-4-carbonitrile
CBNumber:
CB62604963
Molecular Formula:
C16H12N4O
Molecular Weight:
276.29
MOL File:
330792-70-6.mol
Modify Date:
2024/5/16 10:38:37
Request For Quotation

5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile Properties

Boiling point 585.3±50.0 °C(Predicted)
Density 1.37±0.1 g/cm3(Predicted)
refractive index 1.699
Flash point 307.8℃
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility DMSO (Slightly)
pka 10.83±0.50(Predicted)
InChI InChI=1S/C16H12N4O/c17-10-14-15(19-20-16(14)18)11-6-8-13(9-7-11)21-12-4-2-1-3-5-12/h1-9H,(H3,18,19,20)
InChIKey HNIMEQCLCNSCGH-UHFFFAOYSA-N
SMILES N1C(C2=CC=C(OC3=CC=CC=C3)C=C2)=C(C#N)C(N)=N1
LogP 3.25298

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile Chemical Properties,Uses,Production

Chemical Properties

Light yellow to off-white powder.

Application

5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile is an intermediate of Ibrutinib (PCI-32765). it is a heterocyclic intermediate that typically used in the preparation of ACP-196, a selective second-generation BTK inhibitor.

5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile Preparation Products And Raw materials

Raw materials

4-PHENOXYBENZOYL CHLORIDE Propanedinitrile, 2-[hydroxy(4-phenoxyphenyl)Methylene]- Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]- Methyl 4-iodobenzoate 4-PHENOXYBENZOIC ACID
4-Phenoxybenzoic acid methyl ester Phenol Malononitrile
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Preparation Products

3-(4-Phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine

5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile Suppliers

Global( 193)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
SYNGREEN LIFESCIENCES PVT.LTD +919849474297 Telangana, India 82 58 Inquiry
PURALABS +918985212143 Hyderabad, India 99 58 Inquiry
Molkem Chemicals +91-917228022464 +91-7228022464 Ahmedabad, India 138 58 Inquiry
Sris Synthesis Pvt Ltd., +91-9989522441 +91-9989522441 Hyderabad, India 282 58 Inquiry
Credas Labs Pvt Ltd +91 9133918031 Hyderabad, India 119 58 Inquiry
CHEMAZON LABORATORIES +91 9848551964 Hyderabad, India 1320 58 Inquiry
Accrete Pharmaceuticals Private Limited +91-9246370012 +91-9246370012 Hyderabad, India 24 58 Inquiry
ARRKEM LIFE SCIENCES PRIVATE LIMITED +91-8148739767 +91-8148739767 Telangana, India 260 58 Inquiry
Synergene Active Ingredients Pvt. Ltd. +91-04023700774 +91-04023700774 Telangana, India 96 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Supplier Advantage
SYNGREEN LIFESCIENCES PVT.LTD 58
PURALABS 58
Molkem Chemicals 58
Sris Synthesis Pvt Ltd., 58
Credas Labs Pvt Ltd 58
CHEMAZON LABORATORIES 58
Accrete Pharmaceuticals Private Limited 58
ARRKEM LIFE SCIENCES PRIVATE LIMITED 58
Synergene Active Ingredients Pvt. Ltd. 58
A.J Chemicals 58

330792-70-6(5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile)Related Search:

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5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile 3-amino-5-(4-phenoxyphenyl)-1H-Pyrazole-4-carbonitrile 3-AMino-4-cyano-5-(4-phenoxyphenyl)pyrazole 1H-Pyrazole-4-carbonitrile, 3-aMino-5-(4-phenoxyphenyl)- 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile Ibrutinib intermediates N-3 Zanubrutinib Related Compound 6 Zanubrutinib Impurity 8 Ibrutinib intermediate3 IbrutinibN-3 CAS330792-70-6 5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile Zanubrutinib KSM-II : (4-isocyano-3-(4-phenoxyphenyl)-1H-pyrazol-5-amine) Zanubrutinib impurity-8 (3-Amino-4-cyano-5-(4-phenoxyphenyl)pyrazole IbrutinibIntermediate4 Zanubrutinib impurity-20 330792-70-6 330790-70-6 330792-70-6