Quinupristin

CAS No.: 120138-50-3

Chemical Name:: Quinupristin

Synonyms: RP 68888;RP 57669;Antibiotic RP 57669;Quinupristin Mesylate;Quinupristin(RP-57669);Quinupristin Discontinued;Quinupristin/dalfopristin,Quinupristin,antibiotic,Quinupristin-dalfopristin,streptogramin,Inhibitor,Bacterial,inhibit;4-[4-(DiMethylaMino)-N-Methyl-L-phenylalanine]-5-[(2S,5R)-5-[[[(3S)-1-azabicyclo[2.2.2]oct-3-yl]thio]Methyl]-4-oxo-2-piperidinecarboxylic acid]virginiaMycin S1;Virginiamycin S1, 4-[4-(dimethylamino)-N-methyl-L-phenylalanine]-5-[(2S,5R)-5-[[[(3S)-1-azabicyclo[2.2.2]oct-3-yl]thio]methyl]-4-oxo-2-piperidinecarboxylic acid]-

CBNumber:: CB81073487

Molecular Formula:: C53H67N9O10S

Molecular Weight:: 1022.23

MOL File:: 120138-50-3.mol

Modify Date:: 2024/7/2 8:55:17

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Quinupristin Properties

Melting point	~200°
form	Solid
color	White to off-white

Quinupristin Chemical Properties,Uses,Production

Description

Quinupristin is a streptogramin antibiotic that blocks peptide bond formation and peptide extension in bacteria. Quinupristin is usually combined with another streptogramin antibiotic, dalfopristin , to produce quinupristin-dalfopristin complex , known commercially as Synercid. While both quinupristin and dalfopristin have bacteriostatic effects, they act synergistically to kill Gram-positive bacteria, as well as some Gram-negative and anaerobic bacteria.

Uses

Quinupristin is a semi-synthetic analogue of virginiamycin B (ostreogyrcin B, pristinamycin IA, streptogramin B) formed by a Mannich condensation and elimination to generate an exocyclic methylene alpha to the ketone of the 4-piperidinone. Addition of quinucidinylthiol to the methylene group affords quinupristin. The structural changes provide a more hydrophobic compound with a readily ionisable group for generating a salt. Quinupristin is used commercially in synergistic combination with dalfopristin (30:70). There is little published data on the synthesis, biological or antibiotic activity of quinupristin alone, however the combination product is highly effective, including activity against antibiotic resistant strains.

Quinupristin Preparation Products And Raw materials

Raw materials

Preparation Products

Quinupristin Suppliers

Global( 46)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
BOC Sciences	16314854226; +16314854226	United States	19743	58	Inquiry
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	China	52861	58	Inquiry
PT CHEM GROUP LIMITED		China	35426	58	Inquiry
GIHI CHEMICALS CO.,LIMITED	+8618058761490	China	50000	58	Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	China	8474	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	57511	58	Inquiry
Shaanxi Xianhe Biotech Co., Ltd	+8617709210191	China	464	58	Inquiry
Wuhan Topule	+86-02787215551 +86-19945035818	China	8206	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
TargetMol Chemicals Inc.	58
BOC Sciences	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
PT CHEM GROUP LIMITED	58
GIHI CHEMICALS CO.,LIMITED	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Aladdin Scientific	58
Shaanxi Xianhe Biotech Co., Ltd	58
Wuhan Topule	58

120138-50-3(Quinupristin)Related Search:

N-Acetyl-4-piperidone C-(1-METHYL-PIPERIDIN-2-YL)-METHYLAMINE DIISOBUTYL SULFIDE 3-HYDROXYPICOLINAMIDE 1-ETHYL-3-METHYL-4-PIPERIDONE

1-BUTYL-4-PIPERIDONE AC-DL-PHG-OH Quinupristin-dalfopristin ISO-BUTYL ISO-PROPYL SULFIDE CHEMBRDG-BB 9070682

1-ethylpiperidine-2-methylamine Methyl[(1-methylpiperidin-2-yl)methyl]amine ETHYL[(1-METHYLPIPERIDIN-2-YL)METHYL]AMINE 1-butyrylpiperidin-4-one Quinupristin

2-(2-methylpiperidin-1-yl)ethanamine AC-ALA-ALA-ALA-ALA-OME N-methylpiperidine-2-carboxamide

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4-[4-(DiMethylaMino)-N-Methyl-L-phenylalanine]-5-[(2S,5R)-5-[[[(3S)-1-azabicyclo[2.2.2]oct-3-yl]thio]Methyl]-4-oxo-2-piperidinecarboxylic acid]virginiaMycin S1 Antibiotic RP 57669 RP 57669 RP 68888 Quinupristin(RP-57669) Quinupristin Discontinued Quinupristin Mesylate Virginiamycin S1, 4-[4-(dimethylamino)-N-methyl-L-phenylalanine]-5-[(2S,5R)-5-[[[(3S)-1-azabicyclo[2.2.2]oct-3-yl]thio]methyl]-4-oxo-2-piperidinecarboxylic acid]- Quinupristin/dalfopristin,Quinupristin,antibiotic,Quinupristin-dalfopristin,streptogramin,Inhibitor,Bacterial,inhibit 120138-50-3 C53H67N9O10S Amino Acids & Derivatives Aromatics Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals