(R)-3-Benzyloxy-Pyrrolidine Hydrochloride
- CAS No.
- 927819-90-7
- Chemical Name:
- (R)-3-Benzyloxy-Pyrrolidine Hydrochloride
- Synonyms
- (3R)-3-benzyloxypyrrolidine;(R)-3-Benzyloxy Pyrrolidine Hcl;3-phenylmethoxypyrrolidine hydrochloride;(R)-3-BENZYLOXY-PYRROLIDINE HYDROCHLORIDE;(3R)-3-(benzyloxy)pyrrolidine hydrochloride
- CBNumber:
- CB81118928
- Molecular Formula:
- C11H16ClNO
- Molecular Weight:
- 213.71
- MOL File:
- 927819-90-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/11/23 17:50:18
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| HS Code | 2933998090 |
(R)-3-Benzyloxy-Pyrrolidine Hydrochloride Chemical Properties,Uses,Production
Uses
(R)-3-Benzyloxy-Pyrrolidine Hydrochloride is an important organic reagent that can be used as a building block for the synthesis of many organic compounds, such as (R)-ethyl 4-(3-(benzyloxy)pyrrolidin-1-yl)butanoate.
Synthesis
After N-tert-butoxycarbonyl-(R)-3-benzyloxypyrrolidine separately obtained was dissolved in isopropanol and heated to 40 °C, isopropanol solution of hydrogen chloride was dropped for 6 hours. After the reaction finished, the mixture was cooled to 23 °C and was concentrated to distil the solvent away. Further, ethyl acetate was added and the mixture was concentrated, thereby obtaining a concentrate in an amount of about. Then, the concentrate was heated to 40 °C, and isopropanol was added until (R)-3-benzyloxypyrrolidine hydrochloride which had been separated as an oily substance became completely dissolved. After (R) -3-benzyloxypyrrolidine hydrochloride was crystallized by gradually cooling the solution and suitably adding a seed crystal, hexane was further added. At the time, crystallization solvent was in a following proportion: isopropanol/ethyl acetate/hexane = 1/71.5/71.5. A deposited crystal was subjected to filtration under reduced pressure, and the resultant wet crystal was washed with ethyl acetate, and then a wet crystal was dried under reduced pressure, thereby obtaining dry crystal of (R)-3-benzyloxypyrrolidine hydrochloride (yield of 82 %, purity of 99.8 %).
(R)-3-Benzyloxy-Pyrrolidine Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | CHINA | 21149 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30253 | 58 | Inquiry |
| Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | CHINA | 9427 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | China | 25363 | 58 | Inquiry |
| Aromsyn Co., Ltd. | +86-0571-85585865 +8613336024896 | China | 19185 | 58 | Inquiry |
| LEAPCHEM CO., LTD. | +86-852-30606658 | China | 43348 | 58 | Inquiry |
| Amadis Chemical Company Limited | 571-89925085 | China | 131980 | 58 | Inquiry |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 18019252918 | China | 15415 | 55 | Inquiry |