5-FLUORO-1,3-DIMETHYLURACIL
- CAS No.
- 3013-92-1
- Chemical Name:
- 5-FLUORO-1,3-DIMETHYLURACIL
- Synonyms
- Fluorouracil-001;Fluorouracil Impurity 34;1,3-dimethyl-5-fluorouracil;5-FLUORO-1,3-DIMETHYLURACIL;5-Fluoro-1,3-dimethyluracil 99%;5-fluoro-1,3-dimethylpyrimidine-2,4-dione;5-fluoro-1,3-diMethylpyriMidine-2,4(1H,3H)-dione;2,4(1H,3H)-Pyrimidinedione,5-fluoro-1,3-dimethyl-;1,3-Dimethyl-5-fluorouracil, 2,4-Dihydroxy-1,3-dimethyl-5-fluoropyrimidine
- CBNumber:
- CB8116404
- Molecular Formula:
- C6H7FN2O2
- Molecular Weight:
- 158.13
- MOL File:
- 3013-92-1.mol
- Modify Date:
- 2023/7/9 8:28:05
5-FLUORO-1,3-DIMETHYLURACIL Chemical Properties,Uses,Production
Uses
5-Fluoro-1,3-dimethyluracil may be used as starting material in the following processes:
- Regioselective synthesis of tetrahydronaphthocyclobuta[1,2-d]pyrimidinediones.
- To synthesize 5-bis(ethoxycarbonyl)methyl-1,3-dimethyluracil.
- To synthesize new highly conjugated propenylidene derivatives via aromatic Paterno-Buchi type cycloaddition with 1-methoxynaphthalene.
Synthesis Reference(s)
Tetrahedron, 46, p. 3093, 1990 DOI: 10.1016/S0040-4020(01)88400-3
General Description
Oxidation of 5-fluoro-1,3-dimethyluracil (5-FDMU) with m-chloroperbenzoic acid has been described. It is reported as antineoplastic drug. On photoirradiation, 5-fluoro-1,3-dimethyluracil yields the trans-anti cyclobutane dimer and the cis-syn cyclobutane dimer. UV irradiation of 5-FDMU and naphthalene in a protic medium affords 5-(1-naphthyl)uracil, while in aprotic media it undergoes stereoselective 1,4-cycloaddition reaction to give a barrelene derivative. The thermochemical parameters of 5-FDMU has been determined. It reacts with substituted benzenes in the presence of trifluoroacetic acid to generate 5-aryl-1,3-dimethyluracils via photosubstitution.
5-FLUORO-1,3-DIMETHYLURACIL Preparation Products And Raw materials
Raw materials
Preparation Products
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| QUALITY CONTROL SOLUTIONS LTD. | 0755-66853366; 13670046396 | China | 18899 | 58 | Inquiry |