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HYDROXY ITRACONAZOLE

CAS No.: 112559-91-8

Chemical Name:: HYDROXY ITRACONAZOLE

Synonyms: R 63373;HYDROXY ITRACONAZOLE;Itraconazole Impurity 1;2H6]-Hydroxyitraconazole;Ketoconazole Impurity 36;Itraconazole 2-Hydroxy Metabolite;Hydroxy Itraconazole (10mM in DMSO);Itraconazole metabolite Hydroxy Itraconazole;Itraconazole Impurity 8(Hydroxy Itraconazole);Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole

CBNumber:: CB8173597

Molecular Formula:: C35H38Cl2N8O5

Molecular Weight:: 721.63

MOL File:: 112559-91-8.mol

MSDS File:: SDS

Modify Date:: 2023/6/8 9:03:09

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HYDROXY ITRACONAZOLE Properties

Melting point	76-78°C
Boiling point	884.7±75.0 °C(Predicted)
Density	1.44±0.1 g/cm3(Predicted)
storage temp.	-20°C Freezer
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form	Solid
pka	14.72±0.20(Predicted)
color	White to Pale Beige

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501

NFPA 704

	0
2		0

HYDROXY ITRACONAZOLE Chemical Properties,Uses,Production

Description

Hydroxy itraconazole (OH-ITZ) is an active metabolite of the antifungal agent itraconazole . Itraconazole is metabolized by the cytochrome P450 isoform 3A4 (CYP3A4) to form hydroxy itraconazole. Hydroxy itraconazole exhibits in vitro antifungal activity (MIC = 0.019, 0.078, and 0.078 mg/ml against C. albicans, A. fumigatus, and C. neoformans, respectively). Plasma concentration of hydroxy itraconazole is directly correlated to that of the parent compound and is used as an indicator of prophylaxis for fungal infections.

Chemical Properties

Off-White Crystalline Solid

HYDROXY ITRACONAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

HYDROXY ITRACONAZOLE Suppliers

Global( 100)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	China	30253	58	Inquiry
Alfa Chemistry	+1-5166625404	United States	21317	58	Inquiry
China National Standard Pharmaceutical Corporation Limited	+8615391658522	China	11927	58	Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	China	8474	58	Inquiry
Amadis Chemical Company Limited	571-89925085	China	131980	58	Inquiry

Supplier	Advantage
SynZeal Research Pvt Ltd	58
Pharma Affiliates	58
CLEARSYNTH LABS LTD.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
BOC Sciences	58
Career Henan Chemica Co	58
Alfa Chemistry	58
China National Standard Pharmaceutical Corporation Limited	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Amadis Chemical Company Limited	58

112559-91-8(HYDROXY ITRACONAZOLE)Related Search:

Itraconazole 2,4-DIHYDRO-4-[(4-(4-HYDROXYPHENYL)-1-PIPERAZINYL)PHENYL]-2-(1-METHYLPROPYL)-3H-1,2,4-TRIAZOLE-3-ONE 2,4-Dihydro-4-[4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one 1-(4-AMINOPHENYL)-4-(4-METHOXYPHENYL)PIPERAZINE trans-Itraconazole

N-Desalkyl Itraconazole Itraconazole Impurity 34 Butyl Itraconazole KETO ITRACONAZOLE 2,4-Dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-

1-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylMethyl)-1,3-dioxolan-4-yl]Methoxy]phenyl]-4-(4-nitrophenyl)piperazine cis-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl benzoate Des-(1-(sec-butyl)-1H-1,2,4-triazol-5(4H)-one) Itraconazole Propyl Itraconazole (1,2,4-Triazol-4-yl) Itraconazole

cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethyl methanesulphonate Itraconazole Impurity 15 cis-2-(Bromomethyl)-2-(2,4-dichlorophenyl)-1,3-dioxolane-4-ylmethyl benzoate

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HYDROXY ITRACONAZOLE 3H-1,2,4-Triazol-3-one, 4-4-4-4-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxyphenyl-1-piperazinylphenyl-2,4-dihydro-2-(2-hydroxy-1-methylpropyl)- 4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(2-hydroxy-1-methylpropyl)-3H-1,2,4-triazol-3-one R 63373 4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylMethyl)-1,3-dioxolan-4-yl]Methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(2-hydroxy-1-Methylpropyl)- Itraconazole 2-Hydroxy Metabolite Itraconazole metabolite Hydroxy Itraconazole Itraconazole Impurity 8(Hydroxy Itraconazole) Itraconazole Impurity 1 Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole 4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-(3-hydroxybutan-2-yl)-1,2,4-triazol-3-one Hydroxy Itraconazole (10mM in DMSO) Hydroxy Itraconazole D8Q: What is Hydroxy Itraconazole D8 Q: What is the CAS Number of Hydroxy Itraconazole D8 Q: What is the storage condition of Hydroxy Itraconazole D8 Q: What are the applications of Hydroxy Itraconazole D8 Hydroxy ItraconazoleQ: What is Hydroxy Itraconazole Q: What is the CAS Number of Hydroxy Itraconazole Q: What is the storage condition of Hydroxy Itraconazole Q: What are the applications of Hydroxy Itraconazole 2H6]-Hydroxyitraconazole Ketoconazole Impurity 36 112559-91-8 C35H40Cl2N8O4 C35H38Cl2N8O5 Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals Various Metabolites and Impurities Isotooe labelled metabolites metabolites Isotopically Labeled Pharmaceutical Reference Standard