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VINBLASTINE

CAS No.: 865-21-4

Chemical Name:: VINBLASTINE

Synonyms: Rozevin;VINBLASTINE;Vincoblastine;Vincaleucoblastin;Vinblastine (7CI);Vincaleucoblastine;VINBLASTINE 94% BP98;VINBLASTINE SULFATE(RG);Vincristine EP Impurity H;Vinblastine, Vincaleukoblastine

CBNumber:: CB8201955

Molecular Formula:: C46H58N4O9

Molecular Weight:: 810.99

MOL File:: 865-21-4.mol

Modify Date:: 2024/6/28 13:54:27

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VINBLASTINE Properties

Melting point	211-216°
alpha	D23 -32° (c = 0.88 in methanol)
Boiling point	755.65°C (rough estimate)
Density	1.1325 (rough estimate)
refractive index	1.6000 (estimate)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	Chloroform, Dichloromethane, Dimethyl Sulfoxide, Methanol
form	Solid
pka	5.4, 7.4(at 25℃)
color	Yellow
EPA Substance Registry System	Vinblastine (865-21-4)

SAFETY

Risk and Safety Statements

RIDADR	1544
HazardClass	6.1(a)
PackingGroup	II
Toxicity	LD50 intraperitoneal in mouse: 3120ug/kg

VINBLASTINE Chemical Properties,Uses,Production

Description

An alkaloid derived from the periwinkle, Catharanthus roseus (formerly Vinca rosea) used as an antitumor drug in the treatment of Hodgkins lymphoma and other cancers. It binds to the microtubule subunit, tubulin, at a site distinct from that of colchicine and podophyllotoxin. This binding is reversible, temperature dependent and rapid, and results in large tubulin aggregates of highly ordered structure (vinblastine paracrystals).

Physical properties

Appearance: needlelike crystals were produced when recrystallized by methanol. Solubility: soluble in chloroform, acetone, and ethanol. Melting point: 211– 216?°C.?Sulfate melting point of vinblastine is 284–285?°C; hydrochloric acid melting point of vinblastine is 244–246?°C (decomposes). Specific optical rotation: +42°.

Uses

Vinblastine is used for severe lymphoblastic leukemia, Hodgkin’s disease, nonHodgkin’s lymphoma, neuroblastoma, sarcoma, and other cancerous diseases.

Indications

It was recorded in the Pharmacopoeia of the People’s Republic of China (2015), the British Pharmacopoeia (2017), the United States Pharmacopeia (40), the Japanese Pharmacopoeia (17th ed.), the European Pharmacopoeia (9th ed.), and The International Pharmacopoeia (5th ed.).
Vinblastine sulfate injection is used as the first-line therapy to treat Hodgkin lymphoma, lymphocytic leukemia, testis tumor, and choriocarcinoma intravenously in clinical practice generally according to ABVD methods (Adriamycin, bleomycin, vinblastine, and dacarbazine).

Mechanism of action

Vinblastine suppresses cell growth during metaphase, affects amino acid metabolism, in particular at the level of including glutamine acid into the citric acid cycle and preventing it from transformation into urea, and it also inhibits protein and nucleic acid synthesis.

Pharmacokinetics

Leukopenia is the dose-limiting side effect, and dose reductions are warranted in patients with serum bilirubin levels greater than 3 mg/dL. The drug-related impact on erythrocyte and thrombocyte levels usually is insignificant. Like vincristine, it is administered as an IV bolus or infusion. The initial elimination half-life of 3.7 minutes is similar to vincristine, but the 24.8-hour terminal half-life is significantly shorter.

Clinical Use

In addition to the hematologic indications that it shares with vincristine, vinblastine sulfate has found utility in the treatment of advanced testicular carcinoma (often in combination with bleomycin), advanced mycosis fungoides, Kaposi's sarcoma, and histiocytosis X.

VINBLASTINE Preparation Products And Raw materials

Raw materials

Sulfuric acid Benzene

Preparation Products

VINBLASTINE Suppliers

Global( 222)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Green Vision Life Sciences Pvt Ltd.	+91-2067919200 +91-9404953243	Maharashtra, India	30	58	Inquiry
Sakar Healthcare	+91-8976292690 +91-9967572302	Gujarat, India	47	58	Inquiry
Cygnus Healthcare Specialities P Ltd	08048250407Ext 476	Maharashtra, India	3	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Hangzhou Hyper Chemicals Limited	+86-0086-57187702781 +8613675893055	China	295	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29899	58	Inquiry
Shaanxi Pioneer Biotech Co., Ltd .	+8613259417953	China	3000	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	China	34571	58	Inquiry

Supplier	Advantage
Green Vision Life Sciences Pvt Ltd.	58
Sakar Healthcare	58
Cygnus Healthcare Specialities P Ltd	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
CLEARSYNTH LABS LTD.	58
Hangzhou Hyper Chemicals Limited	58
career henan chemical co	58
Shaanxi Pioneer Biotech Co., Ltd .	58
Chongqing Chemdad Co., Ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58

VINBLASTINE Spectrum

VINBLASTINE(865-21-4)MS

865-21-4(VINBLASTINE)Related Search:

Vinpocetine VERBENALIN Vincristine Vetivert oil Verbena Oil

Vincamine Vinorelbine EP Impurity G Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2-oxido-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α)- 3',4'-Anhydrovinblastine Vinorelbine EP Impurity H

LEUROSINE 4'-Deoxy Vincristine Cophylline desacetylnavelbine Vinorelbine EP Impurity F

N-Desmethylvinblastine 4-Desacetyl Vinblastine (R)-3-AMINO-4-(4-METHOXYPHENYL)BUTANOIC ACID

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VINBLASTINE 94% BP98 VINBLASTINE VINBLASTINE SULFATE(RG) [3aR-[3aa,4b,5b,5ab,9(3R*,5S*,7R*,9S*),10bR*,13aa]]-Methyl 4-(acetyloxy)-3a-ethyl-9-[5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-9-(methoxycarbonyl)-2H-3,7-methanoazacycloundecino[5,4-b]indol-9-yl]-3a,4,5,5a,6,11,12,13a-octahydro-5-hydroxy-8-methoxy-6-methyl-1H-indolizino[8,1-cd]carbazole-5-carboxylate 1H-Indolizino[8,1-cd]carbazole, vincaleukoblastine deriv. 1H-Indolizino[8,1-cd]carbazole-5-carboxylic acid, 4-(acetyloxy)-3a-ethyl-9-[5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-9-(methoxycarbonyl)-2H-3,7-methanoazacycloundecino[5,4-b]indol-9-yl]-3a,4,5,5a,6,11,12,13a-octahydro-5-hydroxy-8-methoxy-6-methyl-, methyl ester, [3aR-[3aa,4b,5b,5ab,9(3R*,5S*,7R*,9S*),10bR*,13aa]]- 2H-3,7-Methanoazacycloundecino[5,4-b]indole, vincaleukoblastine deriv. Rozevin Vinblastine (7CI) Vincaleucoblastin Vincaleucoblastine Vincaleukoblastine (6CI, 8CI, 9CI) Vinblastine (base and/or unspecified salts) Vinblastine, Vincaleukoblastine Vinblastine，Vincaleucoblastine，Catharanthine Vincoblastine 1H-Indolizino[8,1-cd]carbazole-5-carboxylic acid, 4-(acetyloxy)-3a-ethyl-9-[5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-9-(Methoxycarbonyl)-2H-3,7-Methanoazacycloundecino[5,4-b]in Vincristine EP Impurity H Vincristine Impurity 8(Vincristine EP Impurity H) Vinblastine-d3 DISCONTINUED. Please see V314002 vincaleukoblastine(vinblastine) *Codeine Phosphate Impurity 2 (Codeine Phosphate EP Impurity B)(Morphine) (3aR,3a1R,4R,5S,5aR,10bR)-Methyl 4-acetoxy-3a-ethyl-9-((3S,5S,7S,9S)-5-ethyl-5-hydroxy-9-(methoxycarbonyl)-2,4,5,6,7,8,9,10-octahydro-1H-3,7-methano[1]azacycloundecino[5,4-b]indol-9-yl)-5-hydroxy-8-methoxy-6-methyl-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate 865-21-4 C46H58N4O9 phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract Inhibitors chemical reagent pharmaceutical intermediate