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LEUROSINE

LEUROSINE Structure
CAS No.
23360-92-1
Chemical Name:
LEUROSINE
Synonyms
amotin;LEUROSINE;nsc-528004;Vinleurosine;Vincristine EP Impurity F;Vincristine EP Impurity F (Leurosine);4'-Deoxy-3',4'-epoxyvincaleucoblastine, 9CI;(3'R,4'S)-3',4'-Oxy-4'-deoxyvincaleukoblastine;Vincristine Impurity 6(Vincristine EP Impurity F);4′-deoxy-3′α,4′α-epoxyvincaleukoblastine(leurosine)
CBNumber:
CB4205283
Molecular Formula:
C46H56N4O9
Molecular Weight:
808.97
MOL File:
23360-92-1.mol
MSDS File:
SDS
Modify Date:
2023/5/4 17:34:36
Request For Quotation

LEUROSINE Properties

Melting point 202-205℃
Density 1.39
pka 11.36±0.60(Predicted)

SAFETY

Risk and Safety Statements

RIDADR  1544
HazardClass  6.1(a)
PackingGroup  II
Toxicity dog,LDLo,intraperitoneal,12mg/kg (12mg/kg),GASTROINTESTINAL: NAUSEA OR VOMITINGGASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA",Eksperimental'naya Onkologiya. Experimental Oncology. Vol. 9(5), Pg. 76, 1987.

LEUROSINE Chemical Properties,Uses,Production

Description

Vinqa rosea yields this complex dimeric alkaloid which forms colourless crystals that are best purified by recrystallization from acetonitrile. It crystallizes with 8 moles of H20 and loses solvent when heated at In-5°C. It is also dextro? rotatory with [α]26D + n° (CHCI3)’ A crystalline SUlphate is known which has m.p. 238-242°C (dec.) and [α]D - 8.3° (MeOH). The N(b)-oxide is identical with pleurosine (q.v.).

Uses

Vinleurosine is an antitumor compound derived from Vinca Rosea.

References

Svoboda., J. Amer. Pharm. Assoc., 47,834 (1959)
Neuss et al., J. Amer. Chern. Soc., 81,4754 (1959)
Revised structure:
Neuss et al., Tetrahedron Lett., 783 (1968)

LEUROSINE Preparation Products And Raw materials

Raw materials

Preparation Products

LEUROSINE Suppliers

Global( 61)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Shaanxi Pioneer Biotech Co., Ltd . +8613259417953 China 3000 58 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
Hefei TNJ Chemical Industry Co.,Ltd. 0551-65418671 China 34571 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
China National Standard Pharmaceutical Corporation Limited +8615391658522 China 11927 58 Inquiry
Zhuhai Anzhe Biotechnology Co,Ltd. 13169972583 China 3015 58 Inquiry
Wuhan ChemFaces Biochemical Co., Ltd. 18607101326 15172504745 China 7059 55 Inquiry
ChemStrong Scientific Co.,Ltd 0755-0755-66853366 13670046396 China 18018 56 Inquiry
Foshan Treasure Biotechnology Co., Ltd 0757-85921206 18520245316 China 12664 58 Inquiry
Supplier Advantage
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Shaanxi Pioneer Biotech Co., Ltd . 58
career henan chemical co 58
Hefei TNJ Chemical Industry Co.,Ltd. 58
TargetMol Chemicals Inc. 58
China National Standard Pharmaceutical Corporation Limited 58
Zhuhai Anzhe Biotechnology Co,Ltd. 58
Wuhan ChemFaces Biochemical Co., Ltd. 55
ChemStrong Scientific Co.,Ltd 56
Foshan Treasure Biotechnology Co., Ltd 58

23360-92-1(LEUROSINE)Related Search:

VincristineM1 4'-Deoxy Vincristine N-Desmethylvinblastine Vinorelbine EP Impurity G Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2-oxido-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α)-
4-Desacetyl Vinblastine 3',4'-Anhydrovinblastine Vinorelbine EP Impurity H Cophylline desacetylnavelbine
Vinorelbine EP Impurity F VINBLASTINE (2R,3R)-3-AMINO-2-HYDROXYHEXANOIC ACID LEUROSINE (R)-3-AMINO-4-(3-METHYLPHENYL)BUTANOIC ACID HYDROCHLORIDE
3-AMINO-4-(4-METHOXY-PHENYL)-BUTYRIC ACID (R)-3-AMINO-4-(4-METHOXYPHENYL)BUTANOIC ACID (2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTYRIC ACID HYDROCHLORIDE
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Vinleurosine 4b-Acetoxy-3,4epoxy-3-hydroxy-16-methoxy-(4 H)-vincaleukoblast-6-ene-23,22dioic Acid Dimethyl Ester (3'R,4'S)-3',4'-Oxy-4'-deoxyvincaleukoblastine (3'alpha,4'alpha)-4'-Deoxy-3',4'-epoxyvincaleukoblastine 4'-Deoxy-3',4'-epoxyvincaleucoblastine, 9CI 4’-deoxy-3’,4’-epoxy-,(3’-alpha,4’-alpha)-vincaleukoblastin 4’-deoxy-3’,4’-epoxy-,(3’alpha,4’alpha)-vincaleukoblastin amotin LEUROSINE nsc-528004 Vincristine Impurity 6(Vincristine EP Impurity F) Vincaleukoblastine,4'-deoxy-3',4'-epoxy-, (3'a,4'a)- Vincaleukoblastine, 4'-deoxy-3',4'-epoxy-, (3'α,4'α)- Vincristine EP Impurity F Vinorelbine EP Impurity E/Leurosine/4b-Acetoxy-3,4epoxy-3-hydroxy-16-methoxy-(4 H)-vincaleukoblast-6-ene-23,22dioic Acid Dimethyl Ester Vincristine EP Impurity F (Leurosine) 4′-deoxy-3′α,4′α-epoxyvincaleukoblastine(leurosine) methyl(3aR,4R,5S,5aR,10bR,13aR)-4-(acetyloxy)-3a-ethyl-9-[(1aS,11S,13S,13aR)-1a-ethyl-11-(methoxycarbonyl)-1a,4,5,10,11,12,13,13a-octahydro-2H-3,13-methano-oxireno[9,10]azacycloundecino[5,4-b]indol-11-yl]-5-hydroxy-8-methoxy-6-methyl-3a,4,5,5a,6,11,12,13a-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate(leurosine) Vincristine EP Impurity F(Vinorelbine EP Impurity E) 23360-92-1 C46H58N4O13S