Cetuximab
- CAS No.
- 205923-56-4
- Chemical Name:
- Cetuximab
- Synonyms
- EGFR antibody;IMC 225;Hsdb 7454;CETUXIMAB;CetuxiMab(C225);Unii-pqx0D8J21j;CETUXIMAB USP/EP/BP;Cetuximab (anti-EGFR);Research Grade Cetuximab;6-Diaminoheptanedioic acid
- CBNumber:
- CB82448505
- Molecular Formula:
- C107H179N35O36S7
- Molecular Weight:
- 2756.23406
- MOL File:
- 205923-56-4.mol
- Modify Date:
- 2025/4/28 21:36:36
Cetuximab Chemical Properties,Uses,Production
Originator
ImClone (US)
Uses
Treatment of EGF receptor-expressing cancers (monoclonal antibod.
brand name
Erbitux
Mechanism of action
Cetuximab, a monoclonal antibody, binds to the extracellular domain of the EGFR, which is overexpressed in many human cancers, including head, neck, and colorectal types. This process prevents the EGFR from binding with its endogenous ligand, blocking the receptor-dependent transduction pathway and providing many antitumor effects involving cell-cycle arrest, induction of apoptosis, inhibition of angiogenesis, inhibition of metastasis, internalization, and downregulation of the EGFR, and enhancement of the sensitivity to radiochemotherapy[1].
Toxicology
The majority of skin toxicities were mild to moderate, symptomatic treatments were effective in controlling them. The skin discomfort caused by cetuximab can affect the quality of life temporarily; with long term treatment, severity of skin toxicity may decrease.
References
[1] W Bou-Assaly, S Mukherji. “Cetuximab (erbitux).” American Journal of Neuroradiology 31 4 (2010): 626–7.
Cetuximab Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| Medicea Impex Private Limited | 07942544983 | Nagpur, India | 24 | 58 | Inquiry |
| Shanghai Minbiotech Co., Ltd. | +8617315815539 | CHINA | 129 | 58 | Inquiry |
| BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | +86-18600796368 +86-18600796368 | China | 485 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21628 | 55 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19552 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29808 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 32222 | 58 | Inquiry |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | China | 10244 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 22855 | 58 | Inquiry |
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