Bisoprolol
- CAS No.
- 66722-44-9
- Chemical Name:
- Bisoprolol
- Synonyms
- 1-(4-((2-isopropoxyethoxy)Methyl)phenoxy)-3-(isopropylaMino)propan-2-ol;Bisoprolo;Cardensiel;Bisoprolol base;Bisoprolol-d5 HeMifuMarate;Bisolo;BISOPROLOL;Bisoprolol-D5;Racemic Bisoprolol;-3-(isopropylamino)
- CBNumber:
- CB8245445
- Molecular Formula:
- C18H31NO4
- Molecular Weight:
- 325.44
- MOL File:
- 66722-44-9.mol
- Modify Date:
- 2024/5/14 16:41:43
| Melting point | 100 °C |
|---|---|
| Boiling point | 445.0±45.0 °C(Predicted) |
| Density | 1.033±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer, Under Inert Atmosphere |
| solubility | Chloroform (Sparingly), Methanol (Slightly) |
| pka | pKa 9.57(H2O(extrap) t=25±1 Iunde?ned Aratmosphere) (Uncertain) |
| color | Yellow |
| Water Solubility | 5.5ug/L(100 ºC) |
| CAS DataBase Reference | 66722-44-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Bisoprolol(66722-44-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H362 |
| Precautionary statements | P202-P263-P264-P270-P301+P312-P308+P313 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| WGK Germany | 1 |
| RTECS | UB8380000 |
| HazardClass | IRRITANT |
Bisoprolol Chemical Properties,Uses,Production
Chemical Properties
Yellow Oil
Uses
Cardensiel is an intermediate in the synthesis of 3,3''-(Isopropylazanediyl)bis(1-(4-((2-isopropoxyethoxy)methyl)phenoxy)propan-2-ol) (I824005), which is an impurtiy of Bisoprolol (B510500), a selective β-adrenergic blocker. Used as an antihypertensive.
Enzyme inhibitor
This oral cardiospecific β-blocker (FWfree-base = 325.45 g/mol; CAS 66722- 44-9; IUPAC: (RS)-1-{4-[(2-isopropoxyethoxy)methyl]phenoxy}-3- (isopropylamino)propan-2-ol), also named Zebeta? (oral tablets as fumarate salt), selectively targets β1-adrenergic receptors, blocking epinephrine stimulation of β1-adrenoreceptors that are concentrated in the heart muscle cells and heart conduction tissue as well as kidney juxtaglomerular cells. Bisoprolol is used to treat hypertension, coronary heart disease, arrhythmias, ischemic heart diseases, and myocardial infarction after the acute event. Given such versatility, bisoprolol is understandably included in the World Health Organization's List of Essential Medicines. Pharmacokinetics: Bioavailability > 90%; Hepatic metabolism (50%) by CYP2D6 and CYP3A4; Biological t1/2 = 10-12 hours.
Bisoprolol Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 120)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Merix Laboratories Pvt Ltd | +91-7893336376 +91-7893336376 | Telangana, India | 50 | 58 | Inquiry |
| Narmada Organics | +91-9601758907 +91-9409133000 | Gujarat, India | 19 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Lavybens Pharma | +91-8790466757 +91-8790466756 | Telangana, India | 80 | 58 | Inquiry |
| Globela Industry Pvt Ltd | +91-2616158000 +91-9998199919 | Gujarat, India | 98 | 58 | Inquiry |
| Vishrudh laboratories pvt ltd | +91-9666132889 +91-8097369002 | Telangana, India | 117 | 58 | Inquiry |
| STANDHARDT INNOVATIONS PVT LTD | +91-9898713574 +91-9898713574 | Gujarat, India | 14 | 58 | Inquiry |
| Medilux Laboratories Pvt Ltd | +91-7292409991 +91-9819666688 | Madhya Pradesh, India | 102 | 58 | Inquiry |
| Sibram Pharmaceutical | +91-8655777550 +91-8655777550 | Maharashtra, India | 244 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Merix Laboratories Pvt Ltd | 58 |
| Narmada Organics | 58 |
| Ralington Pharma | 58 |
| Lavybens Pharma | 58 |
| Globela Industry Pvt Ltd | 58 |
| Vishrudh laboratories pvt ltd | 58 |
| STANDHARDT INNOVATIONS PVT LTD | 58 |
| Medilux Laboratories Pvt Ltd | 58 |
| Sibram Pharmaceutical | 58 |
| Pharma Affiliates | 58 |
66722-44-9(Bisoprolol)Related Search:
Phenetidine
2-Ethoxyphenol
Bisoprolol EP IMpurity B HeMifuMarate (Bisoprolol n-Propyl Derivative HeMifuMarate)
2-Propanol, 1,1'-[methylenebis(4,1-phenyleneoxy)]bis[3-[(1-methylethyl)amino]-
Dehydroxy Bisoprolol
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1-[(1-Methylethyl)amino]-3-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-2-propanol
(R)-1-(Isopropylamino)-3-[4-(2-isopropoxyethoxymethyl)phenoxy]-2-propanol
(R)-1-[(1-Methylethyl)amino]-3-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-2-propanol
1-[isopropylamino]-3-[isopropoxyethoxymethylphenoxy]-2-propanol
1-{4-[(2-Isopropoxyethoxy)methyl]phenoxy}-3-(isopropylamino)-2-propanol
1-{4-[(2-Isopropoxyethoxy)methyl]phenoxy}-3-( isopropylamino)-2-propanol fumaric acid salt
1-(4-((2-Isopropoxyethoxy)
-3-(isopropylamino)
BISOPROLOL
2-PROPANOL, 1-[4-[[2-(1-METHYLETHOXY)ETHOXY]METHYL]PHENOXY]-3-[(1-METHYLETHYL)AMINO]-
Bisoprolol(Hemifumalate)
1-[4-[2-(1-Methylethoxy)ethoxymethyl]phenoxy]-3-(1-methylethylamino)propan-2-ol
Bisoprolol-D5
1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol-d5
(S)-1-(Isopropylamino)-3-[4-(2-isopropoxyethoxymethyl)phenoxy]-2-propanol
(S)-1-(Isopropylamino)-3-[4-[(2-isopropoxyethoxy)methyl]phenoxy]-2-propanol
(S)-1-[(1-Methylethyl)amino]-3-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-2-propanol
1-(p-2-Isopropoxyethoxymethylphenoxy)-3-isopropylaminopropan-2-ol
Racemic Bisoprolol
66722-44-9 Bisoprolol
Bisoprolol D5 FumarateQ: What is
Bisoprolol D5 Fumarate Q: What is the CAS Number of
Bisoprolol D5 Fumarate Q: What is the storage condition of
Bisoprolol D5 Fumarate Q: What are the applications of
Bisoprolol D5 Fumarate
BisoprololQ: What is
Bisoprolol Q: What is the CAS Number of
Bisoprolol Q: What is the storage condition of
Bisoprolol Q: What are the applications of
Bisoprolol
1-[isopropylamino]-3-[isopropoxyethoxymethylphenoxy]-2-propa...
Bisoprolol USP/EP/BP
1-(propan-2-ylamino)-3-[2-(1-propan-2-yloxyethoxymethyl)phenoxy]-2-propanol
Bisolo
Bisoprolol-d5 HeMifuMarate
1-(4-((2-isopropoxyethoxy)Methyl)phenoxy)-3-(isopropylaMino)propan-2-ol
Bisoprolo
Bisoprolol base
Cardensiel
Trimethoprim Impurity 52
(RS)-1-{4-[(2-isopropoxyethoxy)methyl]phenoxy}-3-(isopropylamino)propan-2-ol
66722-44-9
C18H31NO4
C18H26D5NO4
C18H26NO4D5
Isotope Labelled Compounds
API
Intermediates & Fine Chemicals
Isotope Labeled Compounds
Pharmaceuticals