3-(2,2,2-Trimethylhydrazine)methylpropionate bromide
- CAS No.
- 106966-25-0
- Chemical Name:
- 3-(2,2,2-Trimethylhydrazine)methylpropionate bromide
- Synonyms
- Meldonium impurity C CRS;3-(2,2,2-Trimethylhydrazinyl)Methyl Propionate Bromide (Thmp);2-(3-Methoxy-3-oxopropyl)-1,1,1-trimethylhydrazin-1-ium Bromide;3-(2,2,2-Trimethylhydrazinyl)-propanoic acid methyl ester bromide;PROPANOIC ACID, 3-(2,2,2-TRIMETHYLHYDRAZINYL)-, METHYL ESTER BROMIDE;Hydrazinium, 2-(3-methoxy-3-oxopropyl)-1,1,1-trimethyl-, bromide (1:1)
- CBNumber:
- CB82464705
- Molecular Formula:
- C7H17N2O2.Br
- Molecular Weight:
- 241.127
- MOL File:
- 106966-25-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/9 9:30:52
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H412 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P273-P501 |
3-(2,2,2-Trimethylhydrazine)methylpropionate bromide Chemical Properties,Uses,Production
Uses
3-(2,2,2-Trimethylhydrazine)methylpropionate bromide can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.
Synthesis
In a three-necked round bottom flask equipped with a mechanical stirrer, a dropping funnel and a reflux condenser, 172 g (2 mol) of methyl acrylate was added, and under cooling, 132 g (2.2 mol) of 1,1-dimethylhydrazine was added dropwise. After a period of 2 hours, the reaction mixture was heated at the same temperature until methyl 3-(2,2-dimethylhydrazo)propionate was formed (monitored by GM-MS). The above methyl 3-(2,2-dimethylhydrazinyl)propanoate product was dissolved in 40% ethanol (350 ml), cooled to 0 ° C, and methyl bromide (189 g, 1.99 mol) was passed for 1 hour, and the temperature was continued. After stirring for 0, 5 hours, the yellow or brown precipitate was filtered off, and the crude product was washed with acetone (1000 ml). The crude 3-(2,2,2-trimethylhydrazine) propionate methyl bromide was dried (265.7 g, yield 91.0%); the crude product was recrystallized from ethanol and dried to give 219.8 g of pale yellow crystalline powder. The rate is 75.3%, the melting point is 130-132°C, and the main content is 103.3%. (The stability is verified by the stability test. The stability is poor, the color gradually becomes deeper. Because the trace impurities contained in the product have a great influence on the product, it is found to have molecular decay and various indicators. Larger, the product is valid for up to two years).
3-(2,2,2-Trimethylhydrazine)methylpropionate bromide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | China | 18656 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49403 | 58 | Inquiry |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | China | 52861 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | China | 25363 | 58 | Inquiry |
| PT CHEM GROUP LIMITED | China | 35426 | 58 | Inquiry | |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | China | 50003 | 58 | Inquiry |
| Mainchem Co., Ltd. | +86-86-05926210733 +8618030271905 | China | 6572 | 58 | Inquiry |
| Guangzhou Zhenlin Pharmaceutical Technology Co., Ltd | 18102736234 18102736234 | China | 7664 | 58 | Inquiry |
| Shanghai Haohong Scientific Co., Ltd. | 400-400-8210725 | China | 39990 | 58 | Inquiry |