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ChemicalBook > Product Catalog >Pharmaceutical intermediates >4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one Structure
CAS No.
91526-18-0
Chemical Name:
4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one
Synonyms
DMDO-OH;4-(HydroxyMethyl)-5-Methyl-[1,3]dioxol-2-one;AZATMint-D;Azilsartan Impurity 55;Azilasartan medoximil(HPLC-98.2%);4-(hidroximetil)-5-metil-1,3-dioxol-2-ona;4-(hidroxiMetil)-5-Metil-1,3-dioxol-2-one;4-(hydroxymethyl)-5-methyl-l,3-dioxol-2-one;4-(HydroxyMethyl)-5-Methyl-?,3]dioxol-2-one;4-(hydroxymethyl)-5-methyl-1,3-Diaxole-2-one
CBNumber:
CB82515847
Molecular Formula:
C5H6O4
Molecular Weight:
130.1
MOL File:
91526-18-0.mol
Modify Date:
2025/3/18 22:05:36
Request For Quotation

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one Properties

Boiling point 214℃
Density 1.367
Flash point 93℃
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility Chloroform (Slightly), Methanol (Slightly)
form liquid
pka 14.54±0.10(Predicted)
color Pale yellow
InChI InChI=1S/C5H6O4/c1-3-4(2-6)9-5(7)8-3/h6H,2H2,1H3
InChIKey JEQSUJXHFAXJOW-UHFFFAOYSA-N
SMILES O1C(C)=C(CO)OC1=O

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P403+P233-P405-P501
HS Code  2932990090

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one Chemical Properties,Uses,Production

Description

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one is a reagent used in organic synthesis, particularly for the introduction of the non-chiral (oxodioxolenyl)methyl carbamate group to active pharmaceutical ingredients (APIs) to afford the corresponding pro-drug.

Definition

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one can be reacted with oxalyl chloride to afford (5-methyl-2-oxo-1,3-dioxol-4-yl) methylglyoxal chloride, which provides for an alternative approach to introduce the (oxodioxolenyl) methylcarbamate group.

Uses

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one is used in preparation method of key intermediate of olmesartan medoxomil.

Preparation

At 20-25°C, 50 g of 4-chloromethyl-5-methyl-1,3-dioxol-2-one and 45 g of formic acid were added to 500 mL of acetonitrile. The reaction was cooled to 10-15°C followed by 95 g of triethylamine added. The mixture was heated to 60-65°C and stirred for approximately 5-6 h. The reaction system was subsequently cooled to 15-20°C, filtered, and washed with acetonitrile. Collecting filtrate, and the acetonitrile was removed under vacuum to concentrate the solution. The reaction system was again cooled to 25-30°C, and ethyl acetate and water were added. The mixture was then stirred for approximately 15-20 minutes at 25-30°C. Finally, 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one was obtained after further purification.

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one Preparation Products And Raw materials

Raw materials

4,5-Dimethyl-1,3-dioxol-2-one 4-Cloromethyl-5-methyl-1,3-dioxol-2-one 4-forMyloxyMethyl-5-Methyl- 1,3-dioxolene-2-one 4-Bromomethyl-5-methyl-1,3-dioxol-2-one

Preparation Products

Carbonothioic acid, S-ethyl O-((5-methyl-2-oxo-1,3-dioxol-4-yl)methyl) ester

4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one Suppliers

Global( 251)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
ALMELO PRIVATE LIMITED +91-9100991345 +91-8500807769 Telangana, India 114 58 Inquiry
CLEANCHEM LABORATORIES LLP +91-9951015911 +91-9951015911 Mumbai, India 281 58 Inquiry
Honour Lab Limited +919845977466 Telangana, India 164 58 Inquiry
Green Vision Life Sciences Pvt Ltd. +91-2067919200 +91-9404953243 Maharashtra, India 30 58 Inquiry
Paushak Limited +91-2653007932 +91-9727736899 Vadodara, India 59 58 Inquiry
Atul Bioscience Ltd +91-9316723499 +91-9316723499 Maharashtra, India 43 58 Inquiry
Medilux Laboratories Pvt Ltd +91-7292409991 +91-9819666688 Madhya Pradesh, India 102 58 Inquiry
Aravali Pharma And Lifesciences +91-9350857917 +91-9810502945 New Delhi, India 119 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6100 58 Inquiry
Paushak Limited 09727736899 Vadodara, India 22 58 Inquiry
Supplier Advantage
ALMELO PRIVATE LIMITED 58
CLEANCHEM LABORATORIES LLP 58
Honour Lab Limited 58
Green Vision Life Sciences Pvt Ltd. 58
Paushak Limited 58
Atul Bioscience Ltd 58
Medilux Laboratories Pvt Ltd 58
Aravali Pharma And Lifesciences 58
A.J Chemicals 58
Paushak Limited 58

91526-18-0(4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one)Related Search:

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1,3-Dioxol-2-one, 4-(hydroxymethyl)-5-methyl- 4-(hidroximetil)-5-metil-1,3-dioxol-2-ona 4-(hydroxymethyl)-5-methyl-l,3-dioxol-2-one 4-(hidroxiMetil)-5-Metil-1,3-dioxol-2-one 4-Methyl-5-hydroxyMethyl-2-oxo-1,3-dioxol-4-ene AZATMint-D 4-(hidroximetil)-5-metil-1,3-dioxol-2-ona ISO 9001：2015 REACH Azilsartan Impurity 55 Azilasartan medoximil(HPLC-98.2%) 4-(hydroxymethyl)-5-methyl-2H-1,3-dioxol-2-one 4-(HydroxyMethyl)-5-Methyl-[1,3]dioxol-2-one DMDO-OH 4- (hydroxymethyl) -5- methyl -[1,3] dioxolane -2- one 4-(hydroxymethyl)-5-methyl-1,3-Diaxole-2-one 4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-onee-5-oxide 4-(HydroxyMethyl)-5-Methyl-?,3]dioxol-2-one 91526-18-0 94526-18-0