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ChemicalBook > Product Catalog >Analytical Chemistry >Standard >Pharmaceutical Impurity Reference Standards >(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid

(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid

(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid Structure
CAS No.
220352-36-3
Chemical Name:
(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid
Synonyms
(1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxylic acid;Ticagrelor-22;Ticagerelor Impurity;Ticagrelor Related Compound 28;(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid;(1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxylicaci;Cyclopropanecarboxylic acid, 2-(3,4-difluorophenyl)-, (1R,2R)-;(1R-2R)-2-(3,4-DIFLUOROPHENYL)CYCLOPROPANECARBOXYLIC ACID CAS 220352-36-3;Ticagrelor impurity 33/(1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxylic acid
CBNumber:
CB82599546
Molecular Formula:
C10H8F2O2
Molecular Weight:
198.17
MOL File:
220352-36-3.mol
MSDS File:
SDS
Modify Date:
2023/4/23 13:52:06
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(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid Properties

Melting point 78 - 81°C
Boiling point 308.1±42.0 °C(Predicted)
Density 1.435±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Sparingly)
pka 4.53±0.10(Predicted)
form Solid
color Off-White

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2916200090

(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid Chemical Properties,Uses,Production

Uses

(1R,2R)-2-(3,4-Difluorophenyl)-cyclopropanecarboxylic Acid is an intermediate used to prepare AZD6140 as an orally active reversible P2Y12 receptor antagonist for prevention of thrombosis. It is also used to synthesize triazolopyrimidine derivatives as P2T receptor antagonists.

(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid Preparation Products And Raw materials

Raw materials

3,4-difluorocinnaMoyl chloride trans-3,4-Difluorocinnamic acid 2-Chloro-1-(3,4-difluoro-phenyl)-ethanone 3,4-Difluorophenylboronic acid (1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarbonitrile
(1R,2R)-ethyl2-(3,4-difluorophenyl)cyclopropane carboxylate 3,4-DIFLUOROSTYRENE (1S)-2-chloro-1-(3,4-difluorophenyl)-1-ethanol 1,2-Difluoro-4-iodobenzene 1,2-Difluorobenzene
Cyclopropanecarboxylic acid 3,4-Difluorobenzaldehyde Triethyl phosphonoacetate
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Preparation Products

(1R,2R)-2-(3,4-difluorophenyl)cyclopropane carboxaMide (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (2R)-Hydroxy(phenyl)ethanoate

(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid Suppliers

Global( 108)Suppliers
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CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
Shanghai Daken Advanced Materials Co.,Ltd +86-371-66670886 China 16209 58 Inquiry
Henan Tianfu Chemical Co.,Ltd. +86-0371-55170693 +86-19937530512 China 21675 55 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
SIMAGCHEM CORP +86-13806087780 China 17367 58 Inquiry
Chemsigma International Co., Ltd. +86-18136843612 +86-19951791336 China 1229 58 Inquiry
AFINE CHEMICALS LIMITED +86-0571-85134551 China 15395 58 Inquiry
Finetech Industry Limited +86-27-87465837 +8618971612321 China 9626 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
SynZeal Research Pvt Ltd 58
Shanghai Daken Advanced Materials Co.,Ltd 58
Henan Tianfu Chemical Co.,Ltd. 55
career henan chemical co 58
SIMAGCHEM CORP 58
Chemsigma International Co., Ltd. 58
AFINE CHEMICALS LIMITED 58
Finetech Industry Limited 58

220352-36-3((1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid)Related Search:

Ticagrelor iMpurity (1S,2S,3R,5S)-3-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)aMino)-5-(propylsulfinyl)-3H-[1,2,3]triazolo[4,5-d]pyriMidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol Ticagrelor Related Compound 44 4-Chloro-2-propylsulfanyl-pyrimidine 1,2-Cyclopentanediol, 3-[7-aMino-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyriMidin-3-yl]-5-(2-hydroxyethoxy)-, (1S,2S,3R,5S)-
TRANSAMINE Ticagrelor Related Compound 3 (3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)aMino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyriMidin-3-yl)-2,2- 2-(((3aR,4S,6R,6aS)-6-(7-aMino-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyriMidin-3-yl)-2,2-diMethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol Ticagrelor Sulfone
(2S,4S)-1-(tert-butoxycarbonyl)-4-(MethoxyMethyl)pyrrolidine-2-carboxylic acid (2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid Cyclopropanamine,2-(3,4-difluorophenyl)-(1R,2S) -(2R,3R)-2,3-dihydroxybutanedioate (1:1) (1R,2R,3S,5R)-3-(7-((1S,2R)-2-(3,4-difluorophenyl)cyclopropylaMino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyriMidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol (3aS,4R,6S,6aR)-6-AMinotetrahydro-2,2-diMethyl-4H-cyclopenta-1,3-dioxol-4-ol
(1S,2S,3R,5S)-3-(7-hydroxy-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyriMidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol AR-C 124910XX 2-[[(3aR,4S,6R,6aS)-6-(7-azanyl-5-propylsulfanyl-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyl-4,5,6,6a-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl]oxy]ethanol
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(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid Ticagrelor Related Compound 28 Ticagerelor Impurity Ticagrelor-22 Ticagrelor impurity 33/(1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxylic acid Cyclopropanecarboxylic acid, 2-(3,4-difluorophenyl)-, (1R,2R)- (1R-2R)-2-(3,4-DIFLUOROPHENYL)CYCLOPROPANECARBOXYLIC ACID CAS 220352-36-3 (1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxylic acid (1R,2R)-2-(3,4-difluorophenyl)cyclopropane-1-carboxylicaci 220352-36-3