N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-(4-hydroxyphenyl)urea

N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-(4-hydroxyphenyl)urea Structure
CAS No.
1129683-83-5
Chemical Name:
N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-(4-hydroxyphenyl)urea
Synonyms
Sorafenib impurities5;Sorafenib Impurity 65;Sorafenib impurities166;Sorafenib related coMpound 4;1-(4-chloro-3-(trifluromethyl)phenyl)-3-(4-hydroxyphenyl)urea;N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-(4-hydroxyphenyl)urea;N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-(4-hydroxyphenyl)urea;Urea, N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-(4-hydroxyphenyl)-;Sorafenib impurity 17/1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-hydroxyphenyl)urea
CBNumber:
CB82707215
Molecular Formula:
C14H10ClF3N2O2
Molecular Weight:
330.69
MOL File:
1129683-83-5.mol
MSDS File:
SDS
Modify Date:
2023/5/15 10:43:58

N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-(4-hydroxyphenyl)urea Properties

Boiling point 350.1±42.0 °C(Predicted)
Density 1.547±0.06 g/cm3(Predicted)
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 10.16±0.26(Predicted)
color White to Light Yellow

N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-(4-hydroxyphenyl)urea Chemical Properties,Uses,Production

Uses

1-(4-Chloro-3-trifluoromethylphenyl)-3-(4-hydroxyphenyl)urea is an impurity of Sorafenib (S676850), a kinase inhibitor targeting both RAF kinase and receptor tyrosine kinases that promote angiogensis.

N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-(4-hydroxyphenyl)urea Preparation Products And Raw materials

Raw materials

Preparation Products

N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-(4-hydroxyphenyl)urea Suppliers

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Sorafenib related coMpound 4 1-(4-chloro-3-(trifluromethyl)phenyl)-3-(4-hydroxyphenyl)urea Sorafenib impurity 17/1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-hydroxyphenyl)urea N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-(4-hydroxyphenyl)urea Sorafenib impurities166 Sorafenib Impurity 65 Sorafenib impurities5 Urea, N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-(4-hydroxyphenyl)- N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-(4-hydroxyphenyl)urea 1129683-83-5