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4-(4-Aminophenoxy)-N-methylpicolinamide

CAS No.: 284462-37-9

Chemical Name:: 4-(4-Aminophenoxy)-N-methylpicolinamide

Synonyms: 4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide;4-(4-Aminophenoxy)-N-methylpyridine-2-carboxamide;SL-M2;Sorafen;Sorafenib INT2;Sorafenib impurity A;Sorafenib Intermediate;Sorafenib tosylate INT III;Sorafenib Related Compound 23;[4-(4-Aminophenoxy-2-pyridyl)]

CBNumber:: CB31175425

Molecular Formula:: C13H13N3O2

Molecular Weight:: 243.26

MOL File:: 284462-37-9.mol

Modify Date:: 2024/4/1 10:27:31

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4-(4-Aminophenoxy)-N-methylpicolinamide Properties

Melting point	110-112°C
Boiling point	476.8±40.0 °C(Predicted)
Density	1.241±0.06 g/cm3(Predicted)
vapor pressure	0.001-0.05Pa at 20-109.84℃
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	DMSO (Slightly), Methanol (Slightly)
pka	13.96±0.46(Predicted)
color	White to Light yellow to Light orange
LogP	0.9 at 25℃ and pH7
Surface tension	71.71mN/m at 883.8mg/L and 20.1℃

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
HazardClass	IRRITANT
HS Code	2933399990

4-(4-Aminophenoxy)-N-methylpicolinamide price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemicals (India)	A2617	4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide	284462-37-9	1G	₹3500	2022-05-26	Buy
TCI Chemicals (India)	A2617	4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide	284462-37-9	5G	₹8600	2022-05-26	Buy

Product number	Packaging	Price	Buy
A2617	1G	₹3500	Buy
A2617	5G	₹8600	Buy

4-(4-Aminophenoxy)-N-methylpicolinamide Chemical Properties,Uses,Production

Chemical Properties

Light-Brown Solid

Uses

Sorafenib intermediate

Synthesis

To a solution of 4-aminophenol (1 g, 9.2 mmol) in DMF (20 mL) was added 1M potassium ier/-butoxide in THF (9.7 mL, 9.7 mmol) at room temperature. After 2h, (4-chloro(2-pyridyl))-N- methyl carboxamide (1.6 g, 9.2 mmol) and potassium carbonate (0.64 g, 4.6 mmol) were added, and then the reaction mixture was heated to 80 °C for 6h. After cooling, the reaction mixture was extracted with ethyl acetate (50 mL). The organic layer was washed with brine (20 mL) and dried over magnesium sulfate. The solvent was removed in vacuo. The residue was purified by column chromatography to afford 4-(4-Aminophenoxy)-N-methylpicolinamide (2.2 g, 80 %) as a light-brown solid.

4-(4-Aminophenoxy)-N-methylpicolinamide Preparation Products And Raw materials

Raw materials

Preparation Products

N-Methyl-4-(4-(3-(trifluoroMethyl)benzaMido)phenoxy)picolinaMide Tosylate Sorafenib

4-(4-Aminophenoxy)-N-methylpicolinamide Suppliers

Global( 421)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
GLR Innovations	+91 9891111994	New Delhi, India	4542	58	Inquiry
GSV speciality chemicals	+91-91823634932 +91-91823634932	Hyderabad, India	116	58	Inquiry
Sris Synthesis Pvt Ltd.,	+91-9989522441 +91-9989522441	Hyderabad, India	282	58	Inquiry
J S LABS	+91-7330612784 +91-7330612784	Tamil Nadu, India	160	58	Inquiry
KROMOZOME	+91-91-9650900955 +91-09650900955	Maharashtra, India	71	58	Inquiry
GMFC LABS PVT LTD	+91-9133370278 +91-9133370278	Hyderabad, India	44	58	Inquiry
SVK Laboratories Pvt Ltd	+91-40-23095079 +91-9177729915	Telangana, India	89	58	Inquiry
CHEMAZON LABORATORIES	+91 9848551964	Hyderabad, India	1320	58	Inquiry
Delta Finochem Pvt Ltd	+919923159574	Maharashtra, India	67	58	Inquiry
Lakshmi Farmachem	+91-9948795885 +91-9550886476	Telangana, India	407	58	Inquiry

Supplier	Advantage
GLR Innovations	58
GSV speciality chemicals	58
Sris Synthesis Pvt Ltd.,	58
J S LABS	58
KROMOZOME	58
GMFC LABS PVT LTD	58
SVK Laboratories Pvt Ltd	58
CHEMAZON LABORATORIES	58
Delta Finochem Pvt Ltd	58
Lakshmi Farmachem	58

284462-37-9(4-(4-Aminophenoxy)-N-methylpicolinamide)Related Search:

Sorafenib Sorafenib Impurity 35 Sorafenib Impurity 43 1-(4-chloro-3-(trifluoromethyl)phenyl)urea Trimebutine maleate

PYRIDINE-2-CARBOXAMIDE N,N-Dimethylformamide N-Methylformamide SORAFENIB N-OXIDE Sorafenib tosylate

N-Methyl-4-chloropyridine-2-carboxamide 4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine 1,4-Benzoquinoneimine Sorafenib related compound 10 4-HYDROXYPHENYLFORMAMIDE

Sorafenib IMpurity Sorafenib related coMpound 8 Sorafenib Related Compound 21

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4-(4-aMiNApheNAxy)-N-MethylpicolinaMide 4-(4-aMinophenoxy)-N-MethylpicolinaMide oxalate N-Methyl-4-(4-aMinophenoxy)pyridine-2-carboxaMide 4-(4- aMinophenoxy)-N- Methyl-2- pyridineforMaMide 4-(4-Aminophenyloxy)-N-methyl-2-pyridininecarboxamide Sorafenib INT2 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide oxalate 4-(4-Aminophenoxy)-N-methylpicolinamide 4-[[2-(N-Methylcarbamoyl)-4-pyridyl]oxy]anilin 4-[[2-(N-Methylcarbamoyl)-4-pyridyl]oxy]aniline [4-(4-Aminophenoxy-2-pyridyl)] 4-(4-AMino-phenoxy)-pyridine-2-carboxylicacidMethylaMide 4-(4-AMinophenoxy)-pyridine-2-carboxylic acid aMide 4-(4-Aminophenoxy)-N-methylpicolimide [4-(4-Aminophenoxy-2-pyridyl)]-2-methylcarboxamide Sorafenib impurity A Sorafenib Intermediate Sorafenib Related Compound 23 Sorafen Sorafenib Aminophenoxy Impurity Sorafenib tosylate INT III N-Methyl-4-(4-aminophenoxy)pyridine-2-carboxamide Sorafenib Intermediates II 4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide > 2-Pyridinecarboxamide, 4-(4-aminophenoxy)-N-methyl- 4-(2-N-METHYLCARBOMOYL)-4-PYRIDYLOXY)ANILINE 4-(4-Aminophenoxy)-N-methylpicolinamide ISO 9001：2015 REACH 4-(4-Aminophenoxy)-N-methylpicolinamide (Sorafenib Impurity) 4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide 4-(4-Aminophenoxy)-N-methylpyridine-2-carboxamide SL-M2 4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide (IP2014) 284462-37-9 C13H13N3O2C2H2O4 Sorafinib Aromatics Compounds Aromatics Bases & Related Reagents Heterocycles Nucleotides Sorafenib tosylate 284462-37-9