ChemicalBook > Product Catalog >Flavors and fragrances >Synthetic fragrances >Aromatic acid, ester and derivatives >3-(Trifluoromethyl)cinnamic acid
3-(Trifluoromethyl)cinnamic acid
- CAS No.
- 779-89-5
- Chemical Name:
- 3-(Trifluoromethyl)cinnamic acid
- Synonyms
- 3-[3-(TRIFLUOROMETHYL)PHENYL]PROP-2-ENOIC ACID;MTF-CNA;Cinacalcet-27;TIMTEC-BB SBB000553;RARECHEM BK HW 0018;CINMIC ACID IMPURITY;Cinacalcet Impurity 40;3-[3-(Trifluoromethyl)Pheny;m-(Trifluoromethyl)Cinnamic;3-rifluoromethyl)CinnamicAcid
- CBNumber:
- CB8295905
- Molecular Formula:
- C10H7F3O2
- Molecular Weight:
- 216.16
- MOL File:
- 779-89-5.mol
- Modify Date:
- 2024/12/18 14:15:32
| Melting point | 135-137 °C(lit.) |
|---|---|
| Boiling point | 224°C (rough estimate) |
| Density | 1.3275 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 4.25±0.10(Predicted) |
| color | White to Off-White |
| BRN | 1963372 |
| CAS DataBase Reference | 779-89-5(CAS DataBase Reference) |
| EPA Substance Registry System | 3-[3-(Trifluoromethyl)phenyl]acrylic acid (779-89-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-37/38 | |||||||||
| Safety Statements | 26-37/39-37 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29163990 | |||||||||
| NFPA 704 |
|
3-(Trifluoromethyl)cinnamic acid price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemicals (India) | T1547 | 3-(Trifluoromethyl)cinnamic Acid min. 99.0 % | 779-89-5 | 5G | ₹2900 | 2022-05-26 | Buy |
| ALFA India | ALF-A16983-14 | 3-(Trifluoromethyl)cinnamic acid, predominantly trans, 98+% | 779-89-5 | 25g | ₹7990 | 2022-05-26 | Buy |
| TCI Chemicals (India) | T1547 | 3-(Trifluoromethyl)cinnamic Acid min. 99.0 % | 779-89-5 | 25G | ₹11800 | 2022-05-26 | Buy |
| ALFA India | ALF-A16983-06 | 3-(Trifluoromethyl)cinnamic acid, predominantly trans, 98+% | 779-89-5 | 5g | ₹2340 | 2022-05-26 | Buy |
3-(Trifluoromethyl)cinnamic acid Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
Had sedative hypnotic activity in mice, showing potent inhibition of spontaneous motility.
Uses
3-(Trifluoromethyl)cinnamic acid is used in the synthesis of cinacalcet. Cinacalcet is a drug for the control and treatment of secondary hyperparathyroidism (in the dialysis population), primary hyperparathyroidism where the patient may not be a candidate for surgical treatment, and for the treatment of calciphylaxis in patients with end-stage renal disease or in patients on dialysis.
Synthesis
To a suspension of m-trifluoromethyl-α-bromohydrocinnamic acid, isopropanol (1.42 1) and benzyltriethylammonium chloride (10.85g), aqueous sodium hydroxide (340 ml, 56%) was added slowly. The temperature was raised to 55-60℃, stirred for 7 hours, and isopropanol was removed in vacuo. Water (500ml) was added to the reaction mass, stirred, cooled to 0℃, and acidified with hydrochloric acid (450ml). The solid was filtered, washed with water, and dried in vacuo at 5O℃ to afford 204g of 3-(Trifluoromethyl)cinnamic acid.
3-(Trifluoromethyl)cinnamic acid Preparation Products And Raw materials
Global( 432)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEANCHEM LABORATORIES LLP | +91-9951015911 +91-9951015911 | Mumbai, India | 281 | 58 | Inquiry |
| Navin Fuorine International Ltd | +91-2266509999 +91-2266509999 | Hyderabad, India | 40 | 58 | Inquiry |
| SREE SYNERIC LAB | +91-91-6383636810 +91-9884742764 | Tamil Nadu, India | 465 | 58 | Inquiry |
| Horizon | +91-7517039862 +91-7517039862 | Maharashtra, India | 36 | 58 | Inquiry |
| LAIRUS PHARMA PVTLTD | +91-7517039862 +91-7517039862 | Maharashtra, India | 25 | 58 | Inquiry |
| Viyash Life Sciences Pvt Ltd | +91-4023635052 +91-4023635052 | Telangana, India | 213 | 58 | Inquiry |
| Lakshmi Farmachem | +91-9948795885 +91-9550886476 | Telangana, India | 407 | 58 | Inquiry |
| Tulasi Labs | +91-8106722317 +91-8106722317 | Telangana, India | 44 | 58 | Inquiry |
| Anlon Chemical Research Organization | +91-7069690081 +91-7069690082 | Gujarat, India | 21 | 58 | Inquiry |
| ALS INDIA LIFE SCIENCES | +91-8977036379 +91-8977036379 | Hyderabad, India | 1878 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| CLEANCHEM LABORATORIES LLP | 58 |
| Navin Fuorine International Ltd | 58 |
| SREE SYNERIC LAB | 58 |
| Horizon | 58 |
| LAIRUS PHARMA PVTLTD | 58 |
| Viyash Life Sciences Pvt Ltd | 58 |
| Lakshmi Farmachem | 58 |
| Tulasi Labs | 58 |
| Anlon Chemical Research Organization | 58 |
| ALS INDIA LIFE SCIENCES | 58 |
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MTF-CNA
M-TRIFLUOROMETHYL CINNAMIC ACID
RARECHEM BK HW 0018
3-(TRIFLUOROMETHYL)CINNAMIC ACID, 98%, P REDOMINANTLY TRANS
3-(Trifluoromethyl)cinnamic acid 98%
3-(Trifluoromethyl)cinnamicacid98%
m-(Trifluoromethyl)Cinnamic
3-(trifluoromethyl)cinnamic acid, predominantly trans
Cinacalcet Impurity 40
Cinacalcet-27
3-(Trifluoromethyl)cinmic acid
3-(Trifluoromethyl)cinnamic acid USP/EP/BP
3-rifluoromethyl)CinnamicAcid,m-trifluoromethyl cinnamic acid,RARECHEM BK HW 0018,MTF-CAN
3-[3-(TRIFLUOROMETHYL)PHENYL]PROP-2-ENOIC ACID
CINMIC ACID IMPURITY
779-89-5
799-89-5
C10H6F3O2
Organic Building Blocks
Building Blocks
C10
Carbonyl Compounds
Carboxylic Acids
Aromatics
Inhibitors
C10
Carbonyl Compounds
Carboxylic Acids
Miscellaneous
Aromatics Compounds
Aromatic Cinnamic Acids, Esters and Derivatives
779-89-5
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