ALDOSTERONE
- CAS No.
- 52-39-1
- Chemical Name:
- ALDOSTERONE
- Synonyms
- Reichstein;LECTROCORTIN;REICHSTEIN X;μ100 97% (CP);ALD ELISA;NSC 73856;Aldocorten;Aldocortin
- CBNumber:
- CB8431679
- Molecular Formula:
- C21H28O5
- Molecular Weight:
- 360.45
- MOL File:
- 52-39-1.mol
- Modify Date:
- 2024/2/27 22:18:11
| Melting point | 170-172°C |
|---|---|
| alpha | D23 +152.2° (anhydr; c = 2 in acetone); D25 +161° (c = 0.1 in chloroform) |
| Boiling point | 412.46°C (rough estimate) |
| Density | 1.28 |
| refractive index | 1.6120 (estimate) |
| Flash point | 2℃ |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Acetone (Slightly), Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| pka | 12.98±0.10(Predicted) |
| form | Crystalline Powder |
| color | White |
| Water Solubility | 51.18mg/L(37 ºC) |
| Merck | 13,224 |
| BRN | 3224996 |
| CAS DataBase Reference | 52-39-1(CAS DataBase Reference) |
| EPA Substance Registry System | Aldosterone (52-39-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H302+H312+H332-H319 | |||||||||
| Precautionary statements | P210-P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,Xn,F | |||||||||
| Risk Statements | 36/37/38-36-20/21/22-11 | |||||||||
| Safety Statements | 22-24/25-36-26-36/37-16 | |||||||||
| RIDADR | UN 1648 3 / PGII | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TU4523000 | |||||||||
| F | 22-24-25 | |||||||||
| HS Code | 29372900 | |||||||||
| NFPA 704 |
|
ALDOSTERONE price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A9477 | Aldosterone ≥95% (HPLC) | 52-39-1 | 5MG | ₹10586.85 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A9477 | Aldosterone ≥95% (HPLC) | 52-39-1 | 25MG | ₹40030.85 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A9477 | Aldosterone ≥95% (HPLC) | 52-39-1 | 100MG | ₹103367.93 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A-096 | Aldosterone solution 100?μg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant? | 52-39-1 | 1ML | ₹23514.4 | 2022-06-14 | Buy |
ALDOSTERONE Chemical Properties,Uses,Production
Description
Aldosterone is a mineralocorticosteroid that takes part in the regulation of electrolytic balance in the organism. Aldosterone lowers excretion of sodium ions from the body, thus increasing their reabsorption and increasing secretion of potassium ions in renal tubules. Being a competitive antagonist of aldosterone, spironlactone blocks aldosterone receptors, thus increasing excretion of sodium, chloride, and corresponding equivalents of water with urine, thus retaining the amount of potassium ions in the organism. Spironolactone is used both individually as well as in combination with thiazides, since it lowers kaliuresis caused by thiazide diuretics.
Chemical Properties
White Solid
Uses
Labelled Aldosterone. Aldosterone is an adrenocortical steroid which exerts regulatory influence on metabolism of electrolytes and water. Biologically active aldosterone isomer; a mineralocorticoid pr oduced by the adrenal cortex that induces urinary excretion of K+ and renal reabsorptioon of Na+. Exists as an equilibrium mixture of the aldehyde and the hemiacetal.
Definition
ChEBI: A pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, i creased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney.
Health Hazard
Aldosterone(Aldocortin; electrocortin; mineralocorticoid; 18-oxocorticosterone): (1)Maintenance of normal electrolyte blood balances;(2)Prolongs survival of adrenalectomized animals;(3)Accelerates gluconeogenesis;(4)Regulates kidney function.
Purification Methods
Crystallise aldosterone from aqueous acetone. It exists in solution as an equilibrium mixture of free aldehyde and its cyclic hemiacetal, favouring the hemiacetal. The 21-acetate crystallises from Me2CO/Et2O or CH2Cl2/EtOAc and has m 198-199o, [] D +121.7o (c 0.7, CHCl3). [Barton et al. J Chem Soc Perkin Trans 1 2243 1975, Beilstein 8 IV 3491.]
ALDOSTERONE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Neugen Labs | +91-8133254502 +91-8133254502 | Karnataka, India | 195 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29897 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | China | 10326 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | China | 34571 | 58 | Inquiry |
Related articles
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