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GR 113808

GR 113808 Structure
CAS No.
144625-51-4
Chemical Name:
GR 113808
Synonyms
GR 113808;1-[2-(METHYLSULFONYL)-AMINO]ETHYL-4-PIPERIDINYLMETHYL 1-METHYL-1H-INDOLE-3-CARBOXYLATE;1-Methyl-1H-indole-3-carboxylicacid,[1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyles;1-METHYL-1H-INDOLE-3-CARBOXYLIC ACID, [1-[2-[(METHYLSULFONYL)AMINO]ETHYL]-4-PIPERIDINYL]METHYL ESTER;1H-Indole-3-carboxylic acid, 1-methyl-, [1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyl ester;GR 113808;1-METHYL-1H-INDOLE-3-CARBOXYLIC ACID, [1-[2-[(METHYLSULFONYL)AMINO]ETHYL]-4-PIPERIDINYL]METHYL ESTER;1-[2-(METHYLSULFONYL)-AMINO]ETHYL-4-PIPERIDINYLMETHYL 1-METHYL-1H-INDOLE-3-CARBOXYLATE;GR 113808
CBNumber:
CB8494704
Molecular Formula:
C19H27N3O4S
Molecular Weight:
393.5
MOL File:
144625-51-4.mol
MSDS File:
SDS
Modify Date:
2023/6/30 15:45:59
Request For Quotation

GR 113808 Properties

Boiling point 572.3±53.0 °C(Predicted)
Density 1.30±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: 44 mg/mL, soluble
form solid
pka 11.22±0.40(Predicted)
color white

SAFETY

Risk and Safety Statements

WGK Germany  3

GR 113808 price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) G5918 GR 113808 ≥98% (HPLC), solid 144625-51-4 10MG ₹18130 2022-06-14 Buy
Sigma-Aldrich(India) G5918 GR 113808 ≥98% (HPLC), solid 144625-51-4 50MG ₹77670 2022-06-14 Buy
Sigma-Aldrich(India) 5.08120 GR113808 - CAS 144625-51-4 - Calbiochem 144625-51-4 10MG ₹14700.01 2022-06-14 Buy
Product number Packaging Price Buy
G5918 10MG ₹18130 Buy
G5918 50MG ₹77670 Buy
5.08120 10MG ₹14700.01 Buy

GR 113808 Chemical Properties,Uses,Production

Uses

GR 113808 has been used as a serotonin receptor 4 (5-HT4R) blocker to study its effects on the calcium (Ca2+) transients in rat ventricular cardiomyocytes. It has also been used as a 5-HT4R antagonist to study its effects on de novo enteric neurogenesis in post-embryonic zebrafish.

Definition

ChEBI: An indolyl carboxylate ester obtained by formal condensation between the carboxy group of 1-methylindole-3-carboxylic acid with the hydroxy group of N-{2-[4-(hydroxymethyl)piperidin-1-yl]ethyl}methanesulfonamide.

Biological Activity

Potent, selective 5-HT 4 receptor antagonist (pK B = 9.43 in human colonic muscle, and K d = 0.15 nM for binding to cloned human 5-HT 4 receptors). Displays > 300-fold selectivity over 5-HT 1A , 5-HT 1B , 5-HT 2A , 5-HT 2C and 5-HT 3 receptors.

GR 113808 Preparation Products And Raw materials

Raw materials

Preparation Products

GR 113808 Suppliers

Global( 46)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30253 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 52927 58 Inquiry
Cayman Chemical Company (800) 364-9897 United States 6618 81 Inquiry
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 China 8739 58 Inquiry
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 China 4551 58 Inquiry
BOC Sciences 1-631-485-4226; 16314854226 United States 14059 65 Inquiry
DC Chemicals 021-58447131 13564518121 China 9412 58 Inquiry
Nanjing Tengyi Biotechnology Co., Ltd 025-58851786 17714337195 China 5588 58 Inquiry
Energy Chemical 021-58432009 400-005-6266 China 44843 58 Inquiry
Supplier Advantage
TargetMol Chemicals Inc. 58
Career Henan Chemica Co 58
Aladdin Scientific 58
Cayman Chemical Company 81
Shanghai Yifei Biotechnology Co. , Ltd. 58
Nantong QuanYi Biotechnology Co., Ltd 58
BOC Sciences 65
DC Chemicals 58
Nanjing Tengyi Biotechnology Co., Ltd 58
Energy Chemical 58

144625-51-4(GR 113808)Related Search:

[1-(2-aminoethyl)-4-piperidinyl]methanol GR 113808 [3H]GR-113808
1-METHYL-1H-INDOLE-3-CARBOXYLIC ACID, [1-[2-[(METHYLSULFONYL)AMINO]ETHYL]-4-PIPERIDINYL]METHYL ESTER 1-[2-(METHYLSULFONYL)-AMINO]ETHYL-4-PIPERIDINYLMETHYL 1-METHYL-1H-INDOLE-3-CARBOXYLATE GR 113808;1-METHYL-1H-INDOLE-3-CARBOXYLIC ACID, [1-[2-[(METHYLSULFONYL)AMINO]ETHYL]-4-PIPERIDINYL]METHYL ESTER;1-[2-(METHYLSULFONYL)-AMINO]ETHYL-4-PIPERIDINYLMETHYL 1-METHYL-1H-INDOLE-3-CARBOXYLATE;GR 113808 1-Methyl-1H-indole-3-carboxylicacid,[1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyles GR 113808 1H-Indole-3-carboxylic acid, 1-methyl-, [1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]methyl ester 144625-51-4 Serotonin receptor