TICRYNAFEN

TICRYNAFEN Structure
CAS No.
40180-04-9
Chemical Name:
TICRYNAFEN
Synonyms
Tienilic;Tienilic Acid - Ticrynafan;ce3624;ticrex;fr3068;anp3624;ANP 362;skf62698;selacryn;diflurex
CBNumber:
CB8500854
Molecular Formula:
C13H8Cl2O4S
Molecular Weight:
331.17
MOL File:
40180-04-9.mol
MSDS File:
SDS
Modify Date:
2023/6/8 9:01:57

TICRYNAFEN Properties

Melting point 148-149oC
Boiling point 534.6±50.0 °C(Predicted)
Density 1.532
storage temp. -20°C
solubility DMSO: soluble5mg/mL (clear solution)
form powder
pka 2.79±0.10(Predicted)
color white to beige

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
RTECS  AG9300000
Toxicity LD50 in mice (mg/kg): 225 i.v., 1275 orally (US 3758506)
NFPA 704
0
1 0

TICRYNAFEN price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML0505 Tienilic Acid ≥98% (HPLC) 40180-04-9 5MG ₹9190.43 2022-06-14 Buy
Sigma-Aldrich(India) SML0505 Tienilic Acid ≥98% (HPLC) 40180-04-9 25MG ₹37173.05 2022-06-14 Buy
Product number Packaging Price Buy
SML0505 5MG ₹9190.43 Buy
SML0505 25MG ₹37173.05 Buy

TICRYNAFEN Chemical Properties,Uses,Production

Chemical Properties

Pale Beige Solid

Uses

A heterocycloc derivative of phenoxyacetic Acid. Uses as a diuretic, uricosuric, anhtihypertensive

Definition

ChEBI: An aromatic ketone that is 2,3-dichlorophenoxyacetic acid in which the hydrogen at position 4 on the benzene ring is replaced by a thiophenecarbonyl group. A loop diuretic used to treat hypertension, it was withdrawn from the market in 1982 due to links wi h hepatitis.

World Health Organization (WHO)

Tienilic acid, a diuretic agent with uricosuric and antihypertensive activity, was introduced in 1976. By 1979 its use had been associated with cases of hepatic toxicity, some of which were fatal, which led to the withdrawal of the drug in most countries in which it was marketed. In France, however, precautions regarding the use of tienilic acid were issued by the Pharmacovigilance Commission and the drug remained available for another decade. In 1991, it was eventually also withdrawn there since cases of hepatitis, some of which were fulminant, had continued to occur.

TICRYNAFEN Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 103)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Shanghai Daken Advanced Materials Co.,Ltd +86-371-66670886 China 18642 58 Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30250 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 24099 58 Inquiry
Finetech Industry Limited +86-27-87465837 +8618971612321 China 9640 58 Inquiry
Sinoway Industrial co., ltd. 0592-5800732; +8613806035118 China 988 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
LEAPCHEM CO., LTD. +86-852-30606658 China 43348 58 Inquiry

TICRYNAFEN Spectrum

ce3624 diflurex fr3068 selacryn skf62698 thienylicacid ticrex (2,3-dichloro-4-(2-thenoyl)phenoxy)aceticacid (2,3-dichloro-4-(2-thienylcarbonyl)phenoxy)-aceticaci (2,3-dichloro-4-(2-thienylcarbonyl)phenoxy)aceticacid (2,3-dichloro-4-(2-thiophenecarbonyl)phenoxy)aceticacid 4-(2-theonyl)-2,3-dichlorphenoxyessigsaeure 4-(2-thienylketo)-2,3-dichlorophenoxyaceticacid anp3624 tienilicacid [2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy]aceticAcid,TienilicAcid,ThienylicAcid,ANP-3624,CE-3624,SKF-62698,Dif [2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy]acetic Acid, Tienilic Acid, Thienylic Acid, ANP-3624, CE-3624, SKF-62698, Diflurex, Selacryn TIENILIC ACID(TICRYNAFEN) 4-(2-Thienylcarbonyl)-2,3-dichlorophenoxyacetic acid Difluorex Tienylic acid 2-[2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy]acetic Acid 4-(2-Thenoyl)-2,3-dichlorophenoxyacetic Acid 2-{2,3-dichloro-4-[(thiophen-2-yl)carbonyl]phenoxy}acetic acid 2-(2,3-dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid Acetic acid, 2-[2,3-dichloro-4-(2-thienylcarbonyl)phenoxy]- ANP 362 Tienilic Acid Solution, 100ppm TICRYNAFEN USP/EP/BP TICRYNAFEN ISO 9001:2015 REACH Tienilic Tienilic Acid - Ticrynafan Ticrynafen, Tienilic acid ANP 3624,Tienilic Acid,Inhibitor,Uricosuric,Diuretic,inhibit,Hepatotoxicity,ANP3624,Ticrynafen,ANP-3624 ienilicaci Tinic acid(Axitinib Impurity 18) 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid(Tienilic Acid) 40180-04-9 Aromatics Sulfur & Selenium Compounds Heterocyclic Compounds Heterocycles Intermediates & Fine Chemicals Pharmaceuticals