Hederagenin
- CAS No.
- 465-99-6
- Chemical Name:
- Hederagenin
- Synonyms
- Hederidin;NSC 24954;HEDERAGENIN;hederagenol;Hederogenin;Rangefinder;Hederagenine;MELANTHIGENIN;Vaccaric acid;Kalosapogenin
- CBNumber:
- CB8739586
- Molecular Formula:
- C30H48O4
- Molecular Weight:
- 472.71
- MOL File:
- 465-99-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/1/3 18:42:19
| Melting point | 332-334° |
|---|---|
| alpha | D20 +81° (c = 0.7 in pyridine) |
| Boiling point | 493.44°C (rough estimate) |
| Density | 0.9871 (rough estimate) |
| refractive index | 1.4800 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | methanol: soluble1mg/mL |
| pka | 4.63±0.70(Predicted) |
| form | Solid |
| color | White to Off-White |
| λmax | 405nm(H2SO4)(lit.) |
| Merck | 14,4624 |
| InChIKey | PGOYMURMZNDHNS-MYPRUECHSA-N |
| LogP | 7.410 (est) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312+P330-P501 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 22-45-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29181990 | |||||||||
| NFPA 704 |
|
Hederagenin price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | H3916 | Hederagenin ≥97% (HPLC) | 465-99-6 | 10MG | ₹33438.43 | 2022-06-14 | Buy |
| TCI Chemicals (India) | H1645 | Hederagenin | 465-99-6 | 50MG | ₹6400 | 2022-05-26 | Buy |
| TCI Chemicals (India) | H1645 | Hederagenin | 465-99-6 | 200MG | ₹9800 | 2022-05-26 | Buy |
Hederagenin Chemical Properties,Uses,Production
Description
Hederagenin is a triterpene saponin that has been found in P. eximia with diverse biological activities. It increases production of reactive oxygen species (ROS), reduces colony formation, and induces apoptosis in cisplatin-resistant head and neck carcinoma (HNC) cells. In vivo, hederagenin (50, 100, and 200 mg/kg) suppresses tumor growth in a cisplatin-resistant HNC mouse xenograft model. It reduces aortic atherosclerotic lesion area, serum cholesterol and LDL levels, and inducible nitric oxide synthase (iNOS) protein levels in a rat model of atherosclerosis. Hederagenin (50 mg/kg) reduces ethanol-induced production of TNF-α, IL-6, and COX-2, alcohol dehydrogenase 2 (ALDH2) mRNA expression, and liver damage in a rat model of alcohol-induced hepatotoxicity. It also induces autophagy and inhibits oligomerization of α-synuclein in a mouse model of Parkinson''s disease induced by MPTP.
Chemical Properties
White Solid
Uses
Triterpenoid which can inhibit the proliferation of leukemia HL-60 cells.
Definition
ChEBI: A sapogenin that is olean-12-en-28-oic acid substituted by hydroxy groups at positions 3 and 23 (the 3beta stereoisomer).
Hederagenin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Chongqing Zhihe Biopharmaceutical Co., Ltd. | +8618580541567 | China | 303 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21667 | 55 | Inquiry |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | China | 9338 | 55 | Inquiry |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | China | 3777 | 58 | Inquiry |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | China | 3000 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29825 | 58 | Inquiry |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | China | 9907 | 58 | Inquiry |
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