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7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN

7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN Structure
CAS No.
62252-26-0
Chemical Name:
7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN
Synonyms
JLK6;JCP 251);JCP251 (JCP-251;GAMMA-SECRETASE INHIBITOR XI;7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN;7-Amino-4-chloro-3-methoxy-1H-2-benzopyran;7-Amino-4-chloro-3-methoxy-isochromen-1-one;7-Amino-4-chloro-3-methoxy-1H-isochromen-1-one;1H-2-Benzopyran-1-one, 7-amino-4-chloro-3-methoxy-;JLK 6,Amyloid-β,β-amyloid peptide,JLK-6,Abeta,Inhibitor,JLK6,inhibit,APP,amyloid β
CBNumber:
CB8741619
Molecular Formula:
C10H8ClNO3
Molecular Weight:
225.63
MOL File:
62252-26-0.mol
MSDS File:
SDS
Modify Date:
2023/5/18 11:30:58
Request For Quotation

7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN Properties

Melting point 115 °C
Boiling point 456.1±45.0 °C(Predicted)
Density 1.46±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,2-8°C
solubility DMSO (Slightly)
form Solid
pka 1.95±0.20(Predicted)
color Yellow to Beige
Stability Hygroscopic

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362

7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN Chemical Properties,Uses,Production

Uses

JLK 6 is an inhibitor of γ-secretase, selectively inhibits βAPP cleavage.

Biological Activity

Inhibitor of γ -secretase that selectively inhibits β APP cleavage without affecting other γ -secretase-mediated pathways. Prevents recovery of A β 40 and A β 42 from HEK293 cell overexpressing wild-type or Swedish-mutated β APP (IC 50 ~ 30 μ M) but displays no effect on Notch cleavage and Notch-mediated intracellular signaling. Displays no activity on BACE1, BACE2, α -secretase, the proteosome or GSK3 β .

7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN Preparation Products And Raw materials

Raw materials

Preparation Products

7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN Suppliers

Global( 51)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30253 58 Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd +8618327326525 China 8474 58 Inquiry
Jilin Chinese Academy of Sciences-yanshen Technology +undefined18143011203 China 42057 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 52927 58 Inquiry
RD International Technology Co., Limited 18024082417 China 9274 58 Inquiry
Jilin Chinese Academy of Sciences-yanshen Technology 18143011203 China 41844 58 Inquiry
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 China 8739 58 Inquiry
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 China 4551 58 Inquiry
Shanghai Raise Chemical Technology Co.,Ltd 15026594951 China 3374 55 Inquiry
Supplier Advantage
TargetMol Chemicals Inc. 58
Career Henan Chemica Co 58
Wuhan Topule Biopharmaceutical Co., Ltd 58
Jilin Chinese Academy of Sciences-yanshen Technology 58
Aladdin Scientific 58
RD International Technology Co., Limited 58
Jilin Chinese Academy of Sciences-yanshen Technology 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
Nantong QuanYi Biotechnology Co., Ltd 58
Shanghai Raise Chemical Technology Co.,Ltd 55

62252-26-0(7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN)Related Search:

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3-METHOXY-1H-ISOCHROMEN-1-ONE BENZOIC ACID, 5-AMINO-2-METHYL-, METHYL ESTER, HYDROCHLORIDE 1,1-DIMETHOXYETHENE
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JLK6 GAMMA-SECRETASE INHIBITOR XI 7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN 7-Amino-4-chloro-3-methoxy-1H-2-benzopyran JCP 251) JCP251 (JCP-251 7-Amino-4-chloro-3-methoxy-isochromen-1-one 7-Amino-4-chloro-3-methoxy-1H-isochromen-1-one 1H-2-Benzopyran-1-one, 7-amino-4-chloro-3-methoxy- JLK 6,Amyloid-β,β-amyloid peptide,JLK-6,Abeta,Inhibitor,JLK6,inhibit,APP,amyloid β 62252-26-0