Dexmedetomidine
- CAS No.
- Chemical Name:
- Dexmedetomidine
- Synonyms
- CBNumber:
- CB8827836
- Molecular Formula:
- C13H16N2
- Molecular Weight:
- 0
- MOL File:
- Mol file
- Modify Date:
- 2023/4/23 13:52:06
Dexmedetomidine Chemical Properties,Uses,Production
Description
Dexmedetomidine has an eight times increased affinity for the α2-receptor compared with clonidine and therefore produces less cardiovascular instability at comparable doses.
Uses
Dexmedetomidine is principally used as a sedative in mechanically ventilated patients in ICU. I t is particularly useful in those patients with delirium.
Mechanism of action
Dexmedetomidine is metabolised via hepatic glucuronidation, and clearance is reduced in patients with liver impairment. Very li??le unchanged drug reaches the urine, but 95% of degradation products are excreted this way (4% in faeces). There is a theoretical possibility of accumulation of metabolites in patients with renal failure, but toxicity has not been described because active metabolites of dexmedetomidine have not been identified at present.
Pharmacokinetics
Dexmedetomidine is freely soluble in water and has a pKa of 7.1. The pharmaceutical formulation is a clear, colourless preservative-free solution with a pH of 4.5–8. Protein binding of dexmedetomidine is 94%, with negligible displacement by drugs commonly used in anaesthetic and I CU practice. The elimination half-life is approximately 2h and the steady-state volume of distribution is 118 l. There are no significant differences in the pharmacokinetic profile in the elderly, but an enhanced clinical response is seen.
Dexmedetomidine Preparation Products And Raw materials
Raw materials
Preparation Products
Dexmedetomidine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | China | 15395 | 58 | Inquiry |
| sgtlifesciences pvt ltd | +8617013299288 | China | 12382 | 58 | Inquiry |
| Shanghai Xuxin Chemical Technology Co., Ltd | 021-60890630-8009,8011,8036 | China | 58 | 50 | Inquiry |
| Puho Pharmaceutical Co., Ltd. | +86 13760689947, +86 (20) 6227-9976 | China | 477 | 50 | Inquiry |
| Shengyang Runze (Beijing) Technology Co., | 010-010-57302162 17611011830 | China | 169 | 58 | Inquiry |
| Hunan Tengyu New Materials Co., Ltd. | 1822-9738810 18229738810 | China | 113 | 58 | Inquiry |
| 3B Scientific Corporation | 847.281.9822 | United States | 6744 | 47 | Inquiry |
| Lanospharma Laboratories Co.,Ltd | 13440048448 | China | 6343 | 56 | Inquiry |
| CARBONE SCIENTIFIC CO.,LTD | +44(0)870 486 8629 | United Kingdom | 6682 | 30 | Inquiry |
| Shanghai yiji industries Co., Ltd. | 021-60548335 | China | 6294 | 50 | Inquiry |
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