4-chloroquinoline-2-carbonitrile
![4-chloroquinoline-2-carbonitrile Structure](CAS/GIF/4552-43-6.gif)
- CAS No.
- 4552-43-6
- Chemical Name:
- 4-chloroquinoline-2-carbonitrile
- Synonyms
- 4-CHLORO-2-CYANOQUINOLINE;4-chloroquinoline-2-carbonitrile;2-Quinolinecarbonitrile, 4-chloro-
- CBNumber:
- CB8845494
- Molecular Formula:
- C10H5ClN2
- Molecular Weight:
- 188.61
- MOL File:
- 4552-43-6.mol
- Modify Date:
- 2023/5/4 15:16:48
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H315-H332-H335-H312-H319-H302 |
Precautionary statements | P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
4-chloroquinoline-2-carbonitrile Chemical Properties,Uses,Production
Preparation
synthesis of 4-chloroquinoline-2-carbonitrile: To a solution of 2,4-dichloroquinoline (444 mg, 2.24 mmol) in DMF (5 mL) was added zinc cyanide (117 mg, 1.14 mmol) and Pd(PPh3)4 (259 mg, 0.22 mmol). The reaction mixture was stirred at 120 °C for 1 h. A saturated NH4Cl solution (20 mL) was added and the mixture was extracted with ethyl acetate (3x5 mL). The organic layer was washed with a NaCl solution (5mL) and dried over sodium sulfate, filtered and evaporated. The product was further purified by chromatography on silica gel eluting with cyclohexane/ethyl acetate (95:5) to give 4-chloroquinoline-2-carbonitrile (392 mg, 2.085 mmol, 93 %) as a white solid.
4-chloroquinoline-2-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
4-chloroquinoline-2-carbonitrile Suppliers
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4552-43-6(4-chloroquinoline-2-carbonitrile)Related Search:
4-CHLORO-2-CYANOQUINOLINE
4-chloroquinoline-2-carbonitrile
2-Quinolinecarbonitrile, 4-chloro-
4552-43-6