LY 344864

LY 344864 Structure
CAS No.
186544-26-3
Chemical Name:
LY 344864
Synonyms
CS-660;Y344864;LY 344864;LY344864 HCL;LY344864;LY-344864;LY 344864 hydrochloride;LY 344864 hydrochloride, 5-HT1F agonist;(R)-N-[3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide;Benzamide, N-[(3R)-3-(dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluoro-;(R)-N-(3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl)-4-fluorobenzamide hydrochloride
CBNumber:
CB8847478
Molecular Formula:
C21H22FN3O
Molecular Weight:
351.42
MOL File:
186544-26-3.mol
MSDS File:
SDS
Modify Date:
2025/4/17 18:22:24

LY 344864 Properties

Boiling point 471.9±45.0 °C(Predicted)
Density 1.28±0.1 g/cm3(Predicted)
storage temp. Store at +4°C
solubility DMSO : ≥ 350 mg/mL (995.96 mM)
pka 14.12±0.40(Predicted)
form Powder
color White to off-white
Water Solubility water: 10mM
DMSO: 100mM

LY 344864 Chemical Properties,Uses,Production

Biological Activity

Potent, selective 5-HT 1F receptor agonist (EC 50 = 3 nM). Displays > 80-fold selectivity over other 5-HT receptors (K i values are 0.006, 0.53, 0.55, 0.56, 1.42, 1.70, 3.50, 3.94 and 4.85 μ M for 5-HT 1F , 5-HT 1A , 5-HT 1B , 5-HT 1D , 5-HT 1E , 5-HT 2B , 5-HT 2C , 5-HT 2A and 5-HT 7 receptors respectively). Inhibits neurogenic dural inflammation in vivo following i.v. and oral administration.

LY 344864 Preparation Products And Raw materials

Raw materials

Preparation Products

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LY 344864 LY 344864 hydrochloride N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamidehydrochloride (R)-N-[3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide (R)-N-(3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl)-4-fluorobenzamide hydrochloride LY344864 HCL LY344864;LY-344864 CS-660 Y344864 Benzamide, N-[(3R)-3-(dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluoro- migraines,Adrenergic Receptor,BBB penetration,Serotonin Receptor,inhibit,5-HT Receptor,LY-344864,Beta Receptor,Parkinson’s disease,LY 344864,Inhibitor,5-hydroxytryptamine Receptor,5-HT1F LY 344864 hydrochloride, 5-HT1F agonist 186544-26-3 C21H22N3OFHCl Inhibitors