BTO-1
- CAS No.
- 40647-02-7
- Chemical Name:
- BTO-1
- Synonyms
- BTO-1;Polo-like Kinase Inhibitor II, BTO-1;5-Cyano-7-nitro-2-benzothiazolecarboxamide-3-oxide;2-Benzothiazolecarboxamide, 5-cyano-7-nitro-, 3-oxide;Polo-like Kinase Inhibitor II, BTO-1 - CAS 40647-02-7 - Calbiochem
- CBNumber:
- CB8972299
- Molecular Formula:
- C9H4N4O4S
- Molecular Weight:
- 264.22
- MOL File:
- 40647-02-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/4/23 13:52:06
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H312-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 26-36/37 |
| WGK Germany | 3 |
BTO-1 price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | B6311 | BTO-1 ≥98% (HPLC), solid | 40647-02-7 | 5MG | ₹17731.35 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | B6311 | BTO-1 ≥98% (HPLC), solid | 40647-02-7 | 25MG | ₹70827.98 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 528283 | Polo-like Kinase Inhibitor II, BTO-1 - CAS 40647-02-7 - Calbiochem The Polo-like Kinase Inhibitor II, BTO-1, also referenced under CAS 40647-02-7, controls the biological activity of Polo-like Kinase. This small molec | 40647-02-7 | 2MG | ₹9490 | 2022-06-14 | Buy |
BTO-1 Chemical Properties,Uses,Production
General Description
A cell-permeable benzothiazolo-N-oxide compound that targets the ATP-binding pocket of polo-like kinase and is shown to inhibit Plk1 kinase activity in cell-free kinase assays (IC50 = 8.0 μM) and suppress the phosphorylation of cellular Plk1 substrate Cdc25C in rat kangaroo kidney-derived PTK cells (75% inhibition at 6.3 μM). BTO-1 treatment of cultured cells results in mitosis defects consistent with loss-of-Plk1 phenotypes seen in Plk1 RNAi-treated U20S cells, including the appearance of monopolar spindles and the reduction of γ-tubulin at the centrosomes. Plk1 inhibition by BTO-1 in HeLa cells results in a blockage of Rho and Rho-GEF recruitment, which is essential for the assembly of a functional contractile ring.
Biochem/physiol Actions
BTO-1 is a polo-like kinase (Plk) inhibitor.
BTO-1 Preparation Products And Raw materials
Raw materials
Preparation Products
BTO-1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | +86-18521732826 | China | 48465 | 58 | Inquiry |
| TargetMol Chemicals Inc. | 4008200310 | China | 24647 | 58 | Inquiry |
| SIGMA-RBI | 800 736 3690 (Orders) | Switzerland | 6913 | 91 | Inquiry |
| Riedel-de Haen AG | 800 558-9160 | United States | 6825 | 87 | Inquiry |
| Sigma-Aldrich | 021-61415566 800-8193336 | China | 51471 | 80 | Inquiry |
| Shanghai Ziqi Biological Technology Co., Ltd. | 400-811-9081 13681619662 | CHINA | 6192 | 58 | Inquiry |
| Beijing Fubo Biotechnology Co., Ltd. | 010-57263844 13260236521 | CHINA | 6039 | 58 | Inquiry |
| Guangzhou Weijia Technology Co., Ltd. | 020-84224925 18300190102 | CHINA | 6748 | 58 | Inquiry |