BTO-1
- CAS No.
- 40647-02-7
- Chemical Name:
- BTO-1
- Synonyms
- BTO-1;Polo-like Kinase Inhibitor II, BTO-1;5-Cyano-7-nitro-2-benzothiazolecarboxamide-3-oxide;2-Benzothiazolecarboxamide, 5-cyano-7-nitro-, 3-oxide;Polo-like Kinase Inhibitor II, BTO-1 - CAS 40647-02-7 - Calbiochem
- CBNumber:
- CB8972299
- Molecular Formula:
- C9H4N4O4S
- Molecular Weight:
- 264.22
- MOL File:
- 40647-02-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/4/17 18:22:24
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H312-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 26-36/37 |
| WGK Germany | 3 |
BTO-1 price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | B6311 | BTO-1 ≥98% (HPLC), solid | 40647-02-7 | 5MG | ₹17731.35 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | B6311 | BTO-1 ≥98% (HPLC), solid | 40647-02-7 | 25MG | ₹70827.98 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 528283 | Polo-like Kinase Inhibitor II, BTO-1 - CAS 40647-02-7 - Calbiochem The Polo-like Kinase Inhibitor II, BTO-1, also referenced under CAS 40647-02-7, controls the biological activity of Polo-like Kinase. This small molec | 40647-02-7 | 2MG | ₹9490 | 2022-06-14 | Buy |
BTO-1 Chemical Properties,Uses,Production
General Description
A cell-permeable benzothiazolo-N-oxide compound that targets the ATP-binding pocket of polo-like kinase and is shown to inhibit Plk1 kinase activity in cell-free kinase assays (IC50 = 8.0 μM) and suppress the phosphorylation of cellular Plk1 substrate Cdc25C in rat kangaroo kidney-derived PTK cells (75% inhibition at 6.3 μM). BTO-1 treatment of cultured cells results in mitosis defects consistent with loss-of-Plk1 phenotypes seen in Plk1 RNAi-treated U20S cells, including the appearance of monopolar spindles and the reduction of γ-tubulin at the centrosomes. Plk1 inhibition by BTO-1 in HeLa cells results in a blockage of Rho and Rho-GEF recruitment, which is essential for the assembly of a functional contractile ring.
Biochem/physiol Actions
BTO-1 is a polo-like kinase (Plk) inhibitor.
BTO-1 Preparation Products And Raw materials
Raw materials
Preparation Products
BTO-1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| Aladdin Scientific | United States | 52924 | 58 | Inquiry | |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | 400-6206333 13167063860 | China | 48458 | 58 | Inquiry |
| TargetMol Chemicals Inc. | 4008200310 | China | 24683 | 58 | Inquiry |
| Merck KGaA | 21-20338288 | China | 292394 | 58 | Inquiry |
| Absin Bioscience Inc. | 021-38015121-8802 | CHINA | 6208 | 58 | Inquiry |
| BOC Sciences | 1-631-485-4226; 16314854226 | United States | 12952 | 65 | Inquiry |
| Merck Millipore | 1-400-889-1988 400-889-1988 | China | 59839 | 58 | Inquiry |
| SIGMA-RBI | 800 736 3690 (Orders) | Switzerland | 6896 | 91 | Inquiry |
| Riedel-de Haen AG | 800 558-9160 | United States | 6773 | 87 | Inquiry |
| Supplier | Advantage |
|---|---|
| CLEARSYNTH LABS LTD. | 58 |
| Aladdin Scientific | 58 |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
| Merck KGaA | 58 |
| Absin Bioscience Inc. | 58 |
| BOC Sciences | 65 |
| Merck Millipore | 58 |
| SIGMA-RBI | 91 |
| Riedel-de Haen AG | 87 |