BTO-1
|
- ₹9490 - ₹70827.98
- Product name: BTO-1
- CAS: 40647-02-7
- MF: C9H4N4O4S
- MW: 264.22
- EINECS:
- MDL Number:MFCD11045282
- Synonyms:BTO-1;5-Cyano-7-nitro-2-benzothiazolecarboxamide-3-oxide;Polo-like Kinase Inhibitor II, BTO-1 ;Polo-like Kinase Inhibitor II, BTO-1 - CAS 40647-02-7 - Calbiochem;2-Benzothiazolecarboxamide, 5-cyano-7-nitro-, 3-oxide
3 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 2MG
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product number528283
- Product descriptionPolo-like Kinase Inhibitor II, BTO-1 - CAS 40647-02-7 - Calbiochem The Polo-like Kinase Inhibitor II, BTO-1, also referenced under CAS 40647-02-7, controls the biological activity of Polo-like Kinase. This small molec
- Packaging2MG
- Price₹9490
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberB6311
- Product descriptionBTO-1 ≥98% (HPLC), solid
- Packaging5MG
- Price₹17731.35
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberB6311
- Product descriptionBTO-1 ≥98% (HPLC), solid
- Packaging25MG
- Price₹70827.98
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 528283 | Polo-like Kinase Inhibitor II, BTO-1 - CAS 40647-02-7 - Calbiochem The Polo-like Kinase Inhibitor II, BTO-1, also referenced under CAS 40647-02-7, controls the biological activity of Polo-like Kinase. This small molec | 2MG | ₹9490 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | B6311 | BTO-1 ≥98% (HPLC), solid | 5MG | ₹17731.35 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | B6311 | BTO-1 ≥98% (HPLC), solid | 25MG | ₹70827.98 | 2022-06-14 | Buy |
Properties
Boiling point :553.0±60.0 °C(Predicted)
Density :1.89±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :H2O: <2ML/mL
pka :14.67±0.30(Predicted)
form :solid
color :tan
Water Solubility :H2O: <2mL/mL
DMSO: ≥5mg/mL
Density :1.89±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :H2O: <2ML/mL
pka :14.67±0.30(Predicted)
form :solid
color :tan
Water Solubility :H2O: <2mL/mL
DMSO: ≥5mg/mL
Safety Information
| Symbol(GHS): |
|
|||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | |||||||||||||||||||||||||||||||||||||||||||||||||
| Hazard statements: |
|
|||||||||||||||||||||||||||||||||||||||||||||||||
| Precautionary statements: |
|
Description
BTO-1 is a cell-permeable benzothiazolo-N-oxide compound that targets the ATP-binding pocket of polo-like kinase and is shown to inhibit Plk1 kinase activity in cell-free kinase assays (IC50 = 8.0 μM) and suppress the phosphorylation of cellular Plk1 substrate Cdc25C in rat kangaroo kidney-derived PTK cells (75% inhibition at 6.3 μM). BTO-1 treatment of cultured cells results in mitosis defects consistent with loss-of-Plk1 phenotypes seen in Plk1 RNAi-treated U20S cells, including the appearance of monopolar spindles and the reduction of γ-tubulin at the centrosomes. Plk1 inhibition by BTO-1 in HeLa cells results in a blockage of Rho and Rho-GEF recruitment, which is essential for the assembly of a functional contractile ring.Suppliers and manufacturers
CLEARSYNTH LABS LTD.
Aladdin Scientific
Xiamen Huijia Biological Technology Co., Ltd.
Beijing Xiangsheng Xingye Technology Co., Ltd.
Shanghai Yihui Biotechnology Co., Ltd.
Xiamen Research Biotechnology Co., Ltd.
Beijing Zhijie Fangyuan Technology Co., Ltd.
Beijing Taize Jiaye Technology Development Co., Ltd.
Guangzhou Weijia Technology Co., Ltd.
Beijing Fubo Biotechnology Co., Ltd.