3,5-difluorobenzophenone
- CAS No.
- 179113-89-4
- Chemical Name:
- 3,5-difluorobenzophenone
- Synonyms
- 3,5-DIFLUOROBENZOPHENONE;3,5-Difluorobenzophenone97%;3,5-Difluorobenzophenone 97%;3,5-DIFLUOROBENZOPHENONE, 98+%;(3,5-Difluorophenyl)(phenyl)methanone;Methanone, (3,5-difluorophenyl)phenyl-
- CBNumber:
- CB9122835
- Molecular Formula:
- C13H8F2O
- Molecular Weight:
- 218.2
- MOL File:
- 179113-89-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/9/12 18:46:42
Melting point | 57-59°C |
---|---|
Boiling point | 117°C 5mm |
Density | 1.239±0.06 g/cm3(Predicted) |
Flash point | 116-118°C/5mm |
storage temp. | 2-8°C |
form | crystalline solid |
color | Yellow |
BRN | 7919206 |
CAS DataBase Reference | 179113-89-4(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26-36 | |||||||||
HazardClass | IRRITANT | |||||||||
HS Code | 2914390090 | |||||||||
NFPA 704 |
|
3,5-difluorobenzophenone Chemical Properties,Uses,Production
Preparation
Synthesis of 3,5-Difluorobenzophenone: Prior to acylations, 3,5-difluorobenzoic acid was reacted with freshly distilled thionyl chloride and catalytic amounts of DMF(2 drops). After two hours at 55 °C, the excess thionyl chloride was distilled between 75 and 77 °C. The acid halide was then fractionally distilled at 174 °C, and recovery was generally around 75%. To a 50 mL round bottom flask, equipped with a gas inlet, addition funnel, condenser, and drying tube, were added 3.01 g (22.6 mmol) of AlCl3. A mixture of 3.62 g (20.5 mmol) 3,5-difluorobenzoyl chloride and 8.01 g (102.5 mmol) benzene was added dropwise to the AlCl3. The reaction mixture was stirred for 4 hours, before heating to 75 °C. After 16 hours the reaction mixture was quenched by pouring into acidic ice water, followed by addition of 300 mL of chloroform, and transferring to a separatory funnel. The layers were separated and the organic layer was washed with 5 wt. % bicarbonate, distilled water, and then dried with MgSO4 and the solvents were removed, via rotary evaporation, leaving an off-white solid. The crude material was recrystallized from aqueous ethanol to afford (3.00 g, 67 %) of a crystalline white solid with a m.p. 58-59 °C (lit.21 m.p. 57-58 °C); 1H NMR (300 MHz, CDCl3, δ) 7.04 (tt, 1H, J = 8.4, 2.4 Hz), 7.31 (m, 2H), 7.51 (m, 2H), 7.63 (tt, 1H, J = 7.5, 1.2 Hz), 7.78 (m, 2H)
3,5-difluorobenzophenone Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
Speranza Chemical Co., Ltd. | +86-86-075521030354 +8618688942810 | China | 801 | 55 | Inquiry |
Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | China | 10297 | 58 | Inquiry |
Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | China | 14351 | 58 | Inquiry |
Sense Chemicals (Shanghai) Co., Ltd. | +86-21-52751036; +8613818977689 | China | 225 | 58 | Inquiry |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | China | 25363 | 58 | Inquiry |
Aromsyn Co., Ltd. | +86-0571-85585865 +8613336024896 | China | 19185 | 58 | Inquiry |
Hebei Guanlang Biotechnology Co., Ltd. | +8619930503259 | China | 18424 | 58 | Inquiry |
Aceschem Inc. | +1-817863-6948 +1-(817)863-6948 | United States | 19639 | 58 | Inquiry |
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