(-)-Gossypol
- CAS No.
- 90141-22-3
- Chemical Name:
- (-)-Gossypol
- Synonyms
- CS-619;C:C&B61;(R)-Gossypol;(-)-Gossypol;AT 101, >=98%;GOSSYPOL，AT101;(R)-(-)-Gossypol;GOSSYPOL 90141-22-3;(-)-Gossypol USP/EP/BP;DL-gossypol acetic acid
- CBNumber:
- CB91437592
- Molecular Formula:
- C30H30O8
- Molecular Weight:
- 518.55
- MOL File:
- 90141-22-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | 166-167℃ |
|---|---|
| alpha | D28 -386 to -390° (c = 0.5 g/100 g soln in CHCl3) |
| Boiling point | 707.9±55.0 °C(Predicted) |
| Density | 1.403 |
| storage temp. | -20°C |
| solubility | DMSO: soluble15mg/mL, clear |
| form | powder |
| pka | 7.15±0.50(Predicted) |
| color | white to light brown |
| optical activity | [α]/D -350 to -365°, c = 0.3 (CDCl3) |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| WGK Germany | 3 |
(-)-Gossypol Chemical Properties,Uses,Production
Uses
AT-101 is a BH3 mimetic known to be a potent inhibitor of antiapoptotic Bcl-2 family members.
Biological Activity
R-(-)-enantiomer of gossypol (Gossypol). Mimics the BH3 domains of Bcl-2, Bcl-XL and Mcl-1. Disrupts heterodimerization of Bcl-2 with proapoptotic family members. Induces apoptosis in vitro through activation of caspase-9; cytotoxic to multiple myeloma and drug-resistant cell lines. Delays onset of androgen-independent growth of VCaP prostate cancer xenografts in vivo .
Biochem/physiol Actions
AT101 [R-(-)-enantiomer of gossypol] is an orally available and well-tolerated natural BH3-mimetic that activates Bax and also induces mitochondrial Smac release. AT101 has shown anti-tumor activity as a single agent and in combination with standard anticancer drugs in a variety of tumor models. AT101 induced apoptosis in chemoresistant ovarian cancer cells.
(-)-Gossypol Preparation Products And Raw materials
Raw materials
Preparation Products
(-)-Gossypol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | China | 7121 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | China | 8744 | 58 | Inquiry |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | China | 15395 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| Henan Aochuang Chemical Co.,Ltd. | +86-0371-63689365 +8618638391208 | China | 9425 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| Amadis Chemical Company Limited | 571-89925085 | China | 131980 | 58 | Inquiry |
| Shanghai Qiming Biological Technology Co., Ltd. | 021-61483491 | CHINA | 6503 | 58 | Inquiry |
| Sigma-Aldrich | 021-61415566 800-8193336 | China | 51471 | 80 | Inquiry |
| Shaanxi Dideu Newmaterial Co., Ltd. | 029-87576359 15353716720 | China | 10011 | 58 | Inquiry |
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