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1-(6-Methylpyridin-3-yl)-2-(4-(methylsulfonyl)phenyl)ethanone

	1-(6-Methylpyridin-3-yl)-2-(4-(methylsulfonyl)phenyl)ethanone Structure
CAS No.
221615-75-4
Chemical Name:
1-(6-Methylpyridin-3-yl)-2-(4-(methylsulfonyl)phenyl)ethanone
Synonyms
Ketosulfone;1-(6-Methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone;Etoxibu Impurity D;Etocoxi Impurity D;Ketosulfone Powder;Etocoxib impurity 5;Etoricoxib Impurity D;Etoricoxib impurity F;1-(6-methylpyridin-3-yl);Etoricoxib Intermediate 2
CBNumber:
CB91479710
Molecular Formula:
C15H15NO3S
Molecular Weight:
289.35
MOL File:
221615-75-4.mol
Modify Date:
2024/5/16 10:38:37

1-(6-Methylpyridin-3-yl)-2-(4-(methylsulfonyl)phenyl)ethanone Properties

Melting point >169oC (dec.)
Boiling point 509.7±50.0 °C(Predicted)
Density 1.242±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly, Heated)
pka 3.75±0.10(Predicted)
form Solid
color Pale Beige
InChI InChI=1S/C15H15NO3S/c1-11-3-6-13(10-16-11)15(17)9-12-4-7-14(8-5-12)20(2,18)19/h3-8,10H,9H2,1-2H3
InChIKey YBFHILNBYXCJKD-UHFFFAOYSA-N
SMILES C(=O)(C1=CC=C(C)N=C1)CC1=CC=C(S(C)(=O)=O)C=C1

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

1-(6-Methylpyridin-3-yl)-2-(4-(methylsulfonyl)phenyl)ethanone Chemical Properties,Uses,Production

Uses

This compound is an impurity in the synthesis of Etoricoxib (E934100), a specific inhibitor of COX-2 .

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2-(4-MESYLPHENYL)-1-(6-METHYLPYRIDIN-3-YL)- ETHAN-1-ONE 1-(6-Methyl-3-pyridinyl)-2-[4-(Methylsulfonyl)phenyl]-ethanone 2-(4-Mesylphenyl)-1-(6-methylpyridin-3-yl)- ethan-1-one(KETO) 1-(6-methylpyridine-3-yl)-2-(4-(methylsulfonyl)phenyl}ethanol 1-(6-methylpyridin-3-yl)-2- 1-(6 –Methyl- pyridine-3-yl)-2-[(4-Methylsulphonyl) ethanone] 1-(6-Methyl-3-pyridyl)-2-(4-(Methylsulfonyl)-phenyl)ethanone 2-(4-Methanesulfonyl-phenyl)-1-(6-methyl-pyridin-3-yl)-ethanone (Ethanone,1-(6-Methyl-3-pyridinyl)-2-[4-(Methylsulfonyl)phenyl]- ) Etoricoxib Impurity D 2-(4-Mesylphenyl)-l-(6-methylpyridin-3-yl)-ethan-l-one 2-(4-MESYLPHENYL)-1-(6-METHYLPYRIDIN- 2-(4-MESYLPHENYL)-1-(6-METHYLPYRIDIN-3-YL)- ETHAN-1-ONE3-YL)- ETHAN-1-ONE 1-(6-methylpyridin-3-yl) Etoricoxib impurity F Etoricoxib Intermediate 2 Etoxibu Impurity D Etocoxi Impurity D Etoricoxib Related Compound D 1-(6-methyl-3-pyridinyl-2-[4-(methylsulfonyl) phenyl ethenone (Ketosulfone) ETORICOXIB CAS 202409-33-4 INTERMEDIATES l-(6-Methyl pyridin-3-yl)-2-[4-(methyl Sulfonyl) phenyl] Ethanone 2-(4-MESYLPHENYL)-1-(6-METHYLPYRIDIN-3-YL)- ETHAN-1-ONE/1-(6-Methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone Ketosulfone Powder 1-(6-Methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone Ketosulfone 1-(6-methylpyridin-3-yl)-2-(4-(methylsulfonyl)phenyl)ethan-1-one Ketosulfone] 1-(6-methylpyridin-3-yl)-2-[4- (methylsulfonyl) phenyl]ethanone 1-(6-Methylpyridin-3-Yl)-2-[4- (Methylsulfonyl)Phenyl] Ethanone [Ketosulfone 1-(6-methylpyridin-3-yl)-2-(4- (methylsulfonyl)phenyl)ethan-1-one [Ketosulfone 1-(6-Methyl-3-pyridinyl)-2-(4(Methyl sulphonyl)Phenyl)Ethanone Etocoxib impurity 5 2- (4-methylsulfonylphenyl) -1- (6-methylpyridin-3-yl) - ethanone 1-6-Methyl pyridine-3 yl-2 4- Methyl sulfonyl phenyl Etanone (Ketosulphone) 1-(6-methylpyridin-3-yl)-2-(4-(methylsulfonyl)phenyl)ethan-1-one [Ketosulfone] (Intermediate of Etoricoxib ) 221615-75-4 API intermediates RB3 intermediates