Etoricoxib
- CAS No.
- 202409-33-4
- Chemical Name:
- Etoricoxib
- Synonyms
- Arcoxia;Algix;Etocox;Etoxib;MK 663;Tauxib;Etobrix;Kingcox;MK 0663;Nucoxia
- CBNumber:
- CB0223494
- Molecular Formula:
- C18H15ClN2O2S
- Molecular Weight:
- 358.84
- MOL File:
- 202409-33-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/17 21:30:02
| Melting point | 134-135°C |
|---|---|
| Boiling point | 510.0±50.0 °C(Predicted) |
| Density | 1.298±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | DMSO : 100 mg/mL (278.68 mM; Need ultrasonic) |
| pka | 4.5(at 25℃) |
| form | Solid |
| color | Light yellow to yellow |
| BRN | 8073797 |
| InChIKey | MNJVRJDLRVPLFE-UHFFFAOYSA-N |
| CAS DataBase Reference | 202409-33-4(CAS DataBase Reference) |
Etoricoxib price More Price(2)
Etoricoxib Chemical Properties,Uses,Production
Chemical Properties
Off-White Powder
Uses
Labeled Etoricoxib, intended for use as an internal standard for the quantification of Etoricoxib by GC- or LC-mass spectrometry.
Definition
ChEBI: A member of the class of bipyridines that is 2,3'-bipyridine which is substituted at the 3, 5, and 6' positions by 4-(methylsulfonyl)phenyl, chlorine, and methyl groups, respectively.
Pharmacokinetics
Etoricoxib is rapidly absorbed, with an oral bioavailability of 80 to 100%, and reaches maximum plasma concentrations in 1 to 2 hours after dosing. Food decreases the rate of absorption but has no effect on the extent of absorption. It exhibits a long elimination half-life of approximately 22 hours, demonstrating linear plasma pharmacokinetics with no accumulation during multiple dosing.
Clinical Use
Etoricoxib is a selective COX-2 inhibitor being developed for postsurgical treatment of dental pain (120 mg) and osteoarthritis. It has a methylsulfonyl group common to the other coxib inhibitors.
Metabolism
Etoricoxib is metabolized involving oxidation of its 6′-methyl group primarily by CYP3A4 but is not an inhibitor of CYP3A4. Other metabolites include 1′-N-oxide and glucuronides. Etoricoxib is primarily excreted as metabolites into the urine.
Etoricoxib Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| Jigs Chemical ltd | +919099003427 | Gujarat, India | 239 | 58 | Inquiry |
| Cadila Pharmaceuticals Ltd | +91-7069076657 +91-7069076657 | Ahmedabad, India | 54 | 58 | Inquiry |
| J S LABS | +91-7330612784 +91-7330612784 | Tamil Nadu, India | 160 | 58 | Inquiry |
| Viruj Pharmaceuticals Pvt Ltd | +91-9441591589 +91-9441591589 | Hyderabad, India | 33 | 58 | Inquiry |
| SEUTIC | +91-8309787199 +91-8309787199 | Hyderabad, India | 124 | 58 | Inquiry |
| Regal Remedies Ltd a Fluorine | +91-9122140861600 +91-6358839972 | Maharashtra, India | 80 | 58 | Inquiry |
| SURYA LIFE SCIENCES LIMITED | +91-2646226290 +91-9428511112 | Gujarat, India | 62 | 58 | Inquiry |
| SAMSON ORGANICS | +91-8341971897 +91-8341971897 | Hyderabad, India | 15 | 58 | Inquiry |
| AARTIA KEM SCIENCE | +91-8291072530 +91-8291072530 | Maharashtra, India | 70 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| GLR Innovations | 58 |
| Jigs Chemical ltd | 58 |
| Cadila Pharmaceuticals Ltd | 58 |
| J S LABS | 58 |
| Viruj Pharmaceuticals Pvt Ltd | 58 |
| SEUTIC | 58 |
| Regal Remedies Ltd a Fluorine | 58 |
| SURYA LIFE SCIENCES LIMITED | 58 |
| SAMSON ORGANICS | 58 |
| AARTIA KEM SCIENCE | 58 |