ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >Pyridine compound >Hydroxypyridine >2-Hydroxy-3-trifluoromethylpyridine
2-Hydroxy-3-trifluoromethylpyridine
- CAS No.
- 22245-83-6
- Chemical Name:
- 2-Hydroxy-3-trifluoromethylpyridine
- Synonyms
- 3-Trifluoromethyl-pyridin-2-ol;2-HYDROXY-3-(TRIFLUOROMETHYL)PYRIDINE;BUTTPARK 24\01-66;2-Hydroxy-3-(trifL;2-Hydroxy-3-trifluor;2-Hydroxy-3-trifluoromethyl;3-trifluoroMethyl-2-pyridinol;3-(TRIFLUOROMETHYL)-2-PYRIDONE;3-(Trifluoromethyl)-2-pyridinone;3-(Trifluoromethyl)pyridin-2-one
- CBNumber:
- CB9168839
- Molecular Formula:
- C6H4F3NO
- Molecular Weight:
- 163.1
- MOL File:
- 22245-83-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/9/4 23:37:13
| Melting point | 150-153°C |
|---|---|
| Boiling point | 223.7±40.0 °C(Predicted) |
| Density | 1.398±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Room Temperature |
| form | powder to crystal |
| pka | 9.67±0.10(Predicted) |
| color | White to Almost white |
| InChI | InChI=1S/C6H4F3NO/c7-6(8,9)4-2-1-3-10-5(4)11/h1-3H,(H,10,11) |
| InChIKey | JHDCDEHVUADNKQ-UHFFFAOYSA-N |
| SMILES | C1(=O)NC=CC=C1C(F)(F)F |
| LogP | 0.71 at 25℃ |
| CAS DataBase Reference | 22245-83-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,Xn,T | |||||||||
| Risk Statements | 36/37/38-65-20/21/22-20/21-36-25 | |||||||||
| Safety Statements | 26-36/37/39-36-45 | |||||||||
| RIDADR | UN2811 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29333990 | |||||||||
| NFPA 704 |
|
2-Hydroxy-3-trifluoromethylpyridine price More Price(2)
2-Hydroxy-3-trifluoromethylpyridine Chemical Properties,Uses,Production
Description
2-hydroxy-3-(trifluoromethyl)pyridine (or 3-(Trifluoromethyl)-2-pyridone) is a trifluoromethyl substituted 2-hydroxypyridine. It is used as a synthesis intermediate for ligands and bioactive ingredients in the application of drug discovery and catalytic reactions. In catalytic reactions, the amide group of 2-pyridone binds to transition metals, forming stable 5-/6-membered ring intermediates. Hence, 2-hydroxy-3-(trifluoromethyl)pyridine is widely used as a ligand in catalytic reactions such as directed C-H activation on meta-position. In addition, the trifluoromethyl substituent of 3-(trifluoromethyl)-2-pyridone tunes its metal-binding affinity and limits the reaction site for improving regioselectivity.
Chemical Properties
White powder
Uses
2-Hydroxy-3-trifluoromethylpyridine is a reactant in the synthesis of Pyrido[2,3-b]pyrazine, a TRPV1 antagonist .
2-Hydroxy-3-trifluoromethylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 347)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GLR Innovations | +91 9891111994 | New Delhi, India | 4542 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| VASIN BIO LIFE SCIENCES PVT LTD | 9491644688 | Hyderabad, India | 2096 | 58 | Inquiry |
| Qingdao Dexin Chemical Co., Ltd | +86-15553333686 +86-15553333686 | China | 2862 | 58 | Inquiry |
| Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 | China | 5873 | 58 | Inquiry |
| PNP Biotech Co. Ltd | +8618516098983 | China | 1001 | 58 | Inquiry |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | China | 616 | 58 | Inquiry |
| SHANDONG OUCHEM CO.,LTD. | +86-18506360988 +86-18506360988 | China | 48 | 58 | Inquiry |
| Springchem New Material Technology Co.,Limited | +86-021-62885108 +8613917661608 | China | 2068 | 57 | Inquiry |
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3-(TRIFLUOROMETHYL)-1,2-DIHYDROPYRIDIN-2-ONE
3-(TRIFLUOROMETHYL)-2-PYRIDONE
BUTTPARK 24\01-66
3-(Trifluoromethyl)pyridin-2-one
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3-(Trifluoromethyl)-2-pyridinone
2-Hyddroxy-3-trifluoromethylpyridine
2-Hydroxy-3-trifluor
-Hydroxy-3-trifluoroMethylpyridine
3-(Trifluoromethyl)-2-pyridinone
2-Hydroxy-3-(trifluoromethyl)pyridine
2(1H)-Pyridinone, 3-(trifluoroMethyl)-
3-trifluoroMethyl-2-pyridinol
3-Trifluoromethyl-1H-pyridin-2-one
2-Hydroxy-3-trifluoromrthylpyridine
2-Hydroxy-3-(trifL
2-Hydroxy-3-trifluoromethylpyridine ISO 9001：2015 REACH
2-Hydroxy-3-trifluoromethyl
2-Hydroxy-3-trifluoromethylpyridine 22245-83-6
2-HYDROXY-3-(TRIFLUOROMETHYL)PYRIDINE
3-Trifluoromethyl-pyridin-2-ol
2-Hydroy-3-trifluoromethylpyridine
3-(Trifluoromethyl)-2(1H)-pyridinone
22245-83-6
33252-63-1
Fluorine series
blocks
FluoroCompounds
Pyridines
Pyridine