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ChemicalBook > Product Catalog >API >Antipyretic analgesics >Nonsteroidal Anti-Inflammatory Drugs (NSAIDS) >Florfenicol

Florfenicol

Florfenicol Structure
CAS No.
73231-34-2
Chemical Name:
Florfenicol
Synonyms
2,2-dichloro-n-[(1r,2s)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide;NUFLOR;FLUPROFEN;30% water-soluble Florfenicol;4-(2-((dichloroacetyl)amino)-3-fluoro-1-hydroxypropyl)-benzenesulfonicaci;2,2-dichloro-n-(1-(fluoromethyl)-2-hydroxy-2-(4-(methylsulfonyl)phenyl)ethyl;[r-(r*, r*)]-n-[1-(fluoromethyl)-2-hydroxy-2-(4-(methylsulforyl)phenyl)-ethyl]-2,2-dichloroacetamide;AQUAFEN;Aquaflor;SCH-25298
CBNumber:
CB9195978
Molecular Formula:
C12H14Cl2FNO4S
Molecular Weight:
358.21
MOL File:
73231-34-2.mol
MSDS File:
SDS
Modify Date:
2024/7/17 16:57:19
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Florfenicol Properties

Melting point 153 °C
Boiling point 618℃
alpha 26 +17.9° (DMF)
Density 1.451±0.06 g/cm3(Predicted)
RTECS DB6034000
Flash point >110°(230°F)
storage temp. Inert atmosphere,2-8°C
solubility Soluble in ethanol to 25mM and in DMSO to 100mM
form solid
pka 10.73±0.46(Predicted)
color White to Off-White
Merck 14,4109
InChI InChI=1S/C12H14Cl2FNO4S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-15)16-12(18)11(13)14/h2-5,9-11,17H,6H2,1H3,(H,16,18)/t9-,10-/m1/s1
InChIKey AYIRNRDRBQJXIF-NXEZZACHSA-N
SMILES C(N[C@H](CF)[C@H](O)C1=CC=C(S(C)(=O)=O)C=C1)(=O)C(Cl)Cl
CAS DataBase Reference 73231-34-2(CAS DataBase Reference)
EPA Substance Registry System Florfenicol (73231-34-2)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS08,GHS09
Signal word  Danger
Hazard statements  H410-H400-H361-H372
Precautionary statements  P201-P202-P281-P308+P313-P405-P501-P273-P391-P501-P273-P391-P501-P260-P264-P270-P314-P501
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
HS Code  29419090
NFPA 704
0
3 0

Florfenicol price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) F1427 Florfenicol analytical standard, for drug analysis 73231-34-2 500MG ₹20221.1 2022-06-14 Buy
TCI Chemicals (India) F0811 Florfenicol 73231-34-2 1G ₹6700 2022-05-26 Buy
TCI Chemicals (India) F0811 Florfenicol 73231-34-2 5G ₹17500 2022-05-26 Buy
Product number Packaging Price Buy
F1427 500MG ₹20221.1 Buy
F0811 1G ₹6700 Buy
F0811 5G ₹17500 Buy

Florfenicol Chemical Properties,Uses,Production

Description

Florfenicol is a broad-spectrum fluorinated antibiotic and a derivative of thiamphenicol . It is active against human clinical isolates of enteric bacteria, including E. coli, Klebsiella, Enterobacter, Citrobacter, P. mirabilis, and Salmonella (MIC50s = 6.3-12.5 μg/ml). Florfenicol is also active against clinical isolates of various bovine and porcine respiratory tract pathogens, including P. multocida, A. pleuropneumoniae, and B. bronchiseptica (MIC50s = 0.25-4 μg/ml). It inhibits peptidyl transferase activity in 70S ribosomes isolated from E. coli when used at a concentration of 1 mM. Formulations containing florfenicol have been used in the treatment of infectious respiratory disease in cattle.

Chemical Properties

White or off-white crystalline powder, odorless. Easily soluble in dimethylformamide, soluble in methanol, slightly soluble in glacial acetic acid, very slightly soluble in water or chloroform.

Uses

Florfenicol is a fluorinated derivative of thiamphenicol. It is a protein synthesis inhibitor that inhibits bacterial protein synthesis by binding to ribosome 50S and 70S subunits. Florfenicol is used as an antibacterial.

Definition

ChEBI: Florfenicol is a carboxamide that is the N-dichloroacetyl derivative of (1R,2S)-2-amino-3-fluoro-1-[4-(methanesulfonyl)phenyl]propan-1-ol. A synthetic veterinary antibiotic that is used for treatment of bovine respiratory disease and foot rot; also used in aquaculture. It has a role as an antimicrobial agent. It is a sulfone, a secondary alcohol, an organofluorine compound, an organochlorine compound and a secondary carboxamide. It is functionally related to a dichloroacetic acid.

Preparation

Florfenicol is synthesised from thiamphenicol by replacing the 3-hydroxy group with fluorine, first synthesised at Schering in 1980. By replacing the hydroxy group, it was rationalised that chloramphenicol resistance via chloramphenicol acetyltransferase could be eliminated. Florfenicol is a broad spectrum antibiotic with good activity against Gram negative and anaerobic bacteria. It acts by binding to the 23S sub-unit of the 50S ribosome, inhibiting protein synthesis. Florfenicol has been extensively studied with over 400 literature citations.

Florfenicol Preparation Products And Raw materials

Raw materials

(4R,5R)-2-(DICHLOROMETHYL)-4,5-DIHYDRO-5-(4-MESYLPHENYL)OXAZOL-4-YLMETHANOL Oxazole, 2-(dichloromethyl)-4-(fluoromethyl)-4,5-dihydro-5-[4-(methylsulfonyl)phenyl]-, (4S,5R)- 4-Methylsulphonyl benzaldehyde [R(R*,R*]-2-amino-1-[p-(methylsulphonyl)phenyl]propane-1,3-diol ETHYL DICHLOROACETATE
Methyl chloroacetate Dichloroacetic acid methyl ester Dichloroacetyl chloride
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Preparation Products

Florfenicol Suppliers

Global( 610)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
SL Drugs and Pharmaceuticals Pvt. Ltd. +91 (40) 6661-1133 New Delhi, India 2688 50 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Meteoric Biopharmaceuticals Private Limited 08046066618 Ahmedabad, India 23 58 Inquiry
Sai Siddhi 07942551420 Gujarat, India 95 58 Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Rioth Healthcare Private Limited 91-22-28918746 Maharashtra, India 35 58 Inquiry
Anant Pharmaceuticals Pvt. ltd +91 8550986868 Maharashtra, India 736 58 Inquiry
Supplier Advantage
SL Drugs and Pharmaceuticals Pvt. Ltd. 50
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
Meteoric Biopharmaceuticals Private Limited 58
Sai Siddhi 58
TCI Chemicals (India) Pvt. Ltd. 58
SynZeal Research Pvt Ltd 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Rioth Healthcare Private Limited 58
Anant Pharmaceuticals Pvt. ltd 58

Related articles

Florfenicol Spectrum

Florfenicol(73231-34-2)1HNMR

73231-34-2(Florfenicol)Related Search:

FLORFENICOL AMINE, HYDROCHLORIDE 2,2-dichloro-N-[(1R)-3-chloro-1-hydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide Florfenicol Impurity Deschloro Florfenicol florfenicol Soluble
(-)-Florfenicol-d3,Florfenicol-d3 (-)-Pseudoephedrine Florfenicol Florfenicol98%Min (S)-Flurbiprofen
Dichloroacetamide Thiamphenicol N-Trichloroacetyl Florfenicol Amine N-Benzoyl Florfenicol Amine Dideschloro Florfenicol
N-Methyl Florfenicol 2-[(4-METHYLSULFONYL)PHENYL]ETHYLAMINEHYDROCHLORIDE 1-FLUORO-3-PHENYLPROPAN-2-AMINE
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[R-(R*,S*)]-2,2-DICHLORO-N-[1-(FLUOROMETHYL)-2-HYDROXY-2-[4-(METHYLSULFONYL)PHENYL]ETHYL]ACETAMIDE SCH-25298 Florfeniol FLORFENICOL AQUAFEN Fluorothiamphenicol Florfenicol solution,1000ppm Sch-25298, Aquafen 2,2-dichloroacetamide 2,2-Dichloro-N-[(1R,2S)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide [R-(R*,S*)]-2,2-Dichloro-N-[1-(fluoromethyl)-2-hydroxy-2-[4-(methylsulfonyl)phenyl]ethyl]acetamide Aquafen Nuflor Acetamide, 2,2-dichloro-N-(1S,2R)-1-(fluoromethyl)-2-hydroxy-2-4-(methylsulfonyl)phenylethyl- 2,2-Dichloro-N-[(1S,2R)-1-(fluoromethyl)-2-hydroxy-2-[4-(methylsulfonyl)phenyl]ethyl]acetamide Aquaflor Aquafen, Nuflor, SCH-25298, [R-(R*,S*)]-2,2-Dichloro-N-[1-(fluoromethyl)-2-hydroxy-2-[4-(methylsulfonyl)phenyl]ethyl]acetamide 2,2-Dichloro-N-(1-(fluoromethyl)-2-hydroxy-2-(4-(methylsulfonyl)phenyl)ethyl)acetamide 2,2-Dichloro-N-[(1R,2S)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamid Benzenesulfonic acid, 4-(2-((dichloroacetyl)amino)-3-fluoro-1-hydroxypropyl)-, methyl ester, (R-(R*,S*)) [(R-(R*,S*)]-4-[2-[(Dichloroacetyl)amino]-3-fluoro-1-hydroxypropyl]benzensulfonic acid methyl ester Florfenicol ,99% 2,2-Dichloro-N-[(1R,2S)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)-2-propyl]acetamide D-(-)-threo-2-Dichloroacetamido-3-fluoro-1-(4-methylsulfonylphenyl)-1-propanol (-)Florfenicol, Sch 25298 lorfenicol 70% water-soluble Florfenicol FLORFENICOL HCL 10% water-soluble Florfenicol 40% water-soluble Florfenicol (r-(r*,s*))-methyleste Florfenicol, 98%, veterinary antibiotic Florfenicol Solution in Methanol Florfenicol-d2 Fiorfenicol power florfenicol for poultry Florfenicol in stock GMP Factory (76639-94-6) florfenicol Florfenicol> Florfenicol, 98%, reagent grade Florfenicol Standard Florfenicol Water Soluble Powder Florfenicol CVP 2,2-dichloro-N-[(1R,2R)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide Florfenicol Solution in Acetonitrile/Water, 1000μg/mL Fluorine benzene ni 2,2-Dichloro-N-[(1R,2S)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)-2-propyl]acetamide D-(-)-threo-2-Dichloroacetamido-3-fluoro-1-(4-methylsulfonylphenyl)-1-propanol FLORFENICOL POWDER USP/EP/BP florfenicol(Water soluble) USP/EP/BP Florfenicol USP/EP/BP 2,2-dichloro-N-[(1R,2S)-3-fluoro-1-hydroxy-1-(4-m ethanesulfonylphenyl)propan-2-yl]acetamide [R-(R*,S*)]-2,2-DICHLORO-N-[1-(FLUOROMETHYL)-2-HYDROXY-2 4-(2-((dichloroacetyl)amino)-3-fluoro-1-hydroxypropyl)-benzenesulfonicaci 2,2-dichloro-n-[(1r,2s)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide NUFLOR [r-(r*, r*)]-n-[1-(fluoromethyl)-2-hydroxy-2-(4-(methylsulforyl)phenyl)-ethyl]-2,2-dichloroacetamide FLUPROFEN 30% water-soluble Florfenicol 2,2-dichloro-n-(1-(fluoromethyl)-2-hydroxy-2-(4-(methylsulfonyl)phenyl)ethyl Flufenicol Euonymus alatus 73231-34-2