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CYCLOPIAZONIC ACID

CYCLOPIAZONIC ACID Structure
CAS No.
18172-33-3
Chemical Name:
CYCLOPIAZONIC ACID
Synonyms
CPA;CYCLOPIAZONIC ACID;gamma-linolenoyl-CoA;PENICILLIUM CYCLOPIUM;Cyclopiazonic acid,98%;ALPHA CYCLOPIAZONIC ACID;Cyclopiazonic acid (CPA);Penicillium cyclopiumPCR;CYCLOPIAZONICACID,BIOTECHGRADE;Penicillium cyclopium Westling
CBNumber:
CB9207176
Molecular Formula:
C20H20N2O3
Molecular Weight:
336.38
MOL File:
18172-33-3.mol
MSDS File:
SDS
Modify Date:
2023/9/4 15:51:00
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CYCLOPIAZONIC ACID Properties

Melting point 245-246°C
Boiling point 472.86°C (rough estimate)
Density 1.2171 (rough estimate)
refractive index 1.5700 (estimate)
storage temp. -20°C
solubility DMSO: soluble
form powder
pka 4.50±1.00(Predicted)
color white to off-white
Water Solubility Soluble in DMSO (100 mM), ethanol (5 mM), DMF (~20 mg/ml), and 1:1 DMSO:PBS(pH 7.2) (0.5 mg/ml). Insoluble in water.
EPA Substance Registry System Cyclopiazonic acid (18172-33-3)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H300
Precautionary statements  P264-P301+P310
Hazard Codes  T
Risk Statements  25
Safety Statements  36/37/39-45
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS  UY8587000
HazardClass  6.1(a)
PackingGroup  II
HS Code  29337900
Toxicity chicken,LD50,oral,12mg/kg (12mg/kg),Poultry Science. Vol. 65(Suppl,
NFPA 704
0
4 0

CYCLOPIAZONIC ACID price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) C1530 Cyclopiazonic acid from Penicillium cyclopium ≥98% (HPLC), powder 18172-33-3 5MG ₹12795.15 2022-06-14 Buy
Sigma-Aldrich(India) C1530 Cyclopiazonic acid from Penicillium cyclopium ≥98% (HPLC), powder 18172-33-3 10MG ₹19874.7 2022-06-14 Buy
Sigma-Aldrich(India) C1530 Cyclopiazonic acid from Penicillium cyclopium ≥98% (HPLC), powder 18172-33-3 50MG ₹74411.05 2022-06-14 Buy
Sigma-Aldrich 239805 Cyclopiazonic Acid, Penicillium cyclopium - CAS 18172-33-3 - Calbiochem A cell-permeable, reversible inhibitor of sarcoplasmic reticulum Ca2+-ATPase that releases Ca2+ from the same intracellular pools as Thapsigargin. 18172-33-3 5MG ₹8310 2022-06-14 Buy
Sigma-Aldrich(India) 239805 Cyclopiazonic Acid, Penicillium cyclopium - CAS 18172-33-3 - Calbiochem A cell-permeable, reversible inhibitor of sarcoplasmic reticulum Ca2+-ATPase that releases Ca2+ from the same intracellular pools as Thapsigargin. 18172-33-3 5MG ₹8310 2022-06-14 Buy
Product number Packaging Price Buy
C1530 5MG ₹12795.15 Buy
C1530 10MG ₹19874.7 Buy
C1530 50MG ₹74411.05 Buy
239805 5MG ₹8310 Buy
239805 5MG ₹8310 Buy

CYCLOPIAZONIC ACID Chemical Properties,Uses,Production

Description

Cyclopiazonic acid is a mycotoxin that has been found in Penicillium and Aspergillus and an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA; IC50 = 0.6 μM). In vivo, cyclopiazonic acid (11-14 mg/kg) induces ptosis, hypothermia, tremor, and cachexia, as well as induces lethality (LD50 = 13 mg/kg), in rats. It induces tachycardia and sedation in rabbits when administered at a dose of 10 mg/kg.

Chemical Properties

off-white powder or crystals

Uses

Cyclopiazonic acid is a tremorigenic indole produced by several species of Aspergillus and Penicillium. Cyclopiazonic acid is a highly specific inhibitor of calcium ATPase of sarcoplasmic reticulum, altering calcium homeostasis and ATP-dependent calcium transport and resulting in the release of intracellular stored Ca2+ without increasing IP3.

General Description

Cyclopiazonic acid (CPA), a tetramic acid is synthesized by various Aspergillus and Penicillium species.

Biological Activity

Cell-permeable, reversible inhibitor of sarcoplasmic reticulum Ca 2+ -ATPase.

CYCLOPIAZONIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

CYCLOPIAZONIC ACID Suppliers

Global( 101)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
BOC Sciences 16314854226; +16314854226 United States 19743 58 Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd +8618327326525 China 8474 58 Inquiry
Shanghai Acmec Biochemical Technology Co., Ltd. +undefined18621343501 China 33350 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Shanghai Aladdin Biochemical Technology Co.,Ltd. +86-18521732826 China 48467 58 Inquiry
RD International Technology Co., Limited 18024082417 China 9282 58 Inquiry
Beijing Keyi Tongda Technology Development Co., Ltd 17743531240 China 1388 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
ATK CHEMICAL COMPANY LIMITED 60
TargetMol Chemicals Inc. 58
BOC Sciences 58
Wuhan Topule Biopharmaceutical Co., Ltd 58
Shanghai Acmec Biochemical Technology Co., Ltd. 58
Aladdin Scientific 58
Shanghai Aladdin Biochemical Technology Co.,Ltd. 58
RD International Technology Co., Limited 58
Beijing Keyi Tongda Technology Development Co., Ltd 58

CYCLOPIAZONIC ACID Spectrum

CYCLOPIAZONIC ACID(18172-33-3)1HNMR

18172-33-3(CYCLOPIAZONIC ACID)Related Search:

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1-Butylpyrrolidin-2-one ACETIC ACID-DIISOPROPYLAMIDE 1-Methylpyrrolidin-3-one 2-AZACYCLOOCTANONE 4-(1H-INDOL-3-YL)BUTAN-2-ONE
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-Cyclopiazonic acid / CPA Cyclopiazonic acid from Penicillium grisefulvum Cyclopiazonic acid (CPA) Cyclopiazonic acid, FroM PenicilliuM griseofulvuM (6aR,11aS,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-2,6,6a,7,11a,11b-hexahydro-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one (6a-alpha,11a,11b-alpha)--10-acetyl-7-dimethyl-11-hydroxy- 9h-pyrrolo(1’,2’:2,3)isoindolo(4,5,6-cd)indol-9-one,2,6,6a,7,11a,11b-hexahydro (6AA, 10Z, 11AB, 11BA)-6A,7,11A,11B-TETRAHYDRO-10-(1-HYDROXYETHYLIDENE)-7,7- DIMETHYL-6H-PYRROLO [1',2':2,3]ISOINDOLO [4,5,6-CD]INDOLE-9,11 (2H,10H)-DIONE (6AR,11AS,11BR)-REL-10-ACETYL-2,6,6A,7,11A,11B-HEXAHYDRO-7,7-DIMETHYL-9H-PYRROLO[1',2':2,3]ISOINDOLO[4,5,6-CD]INDOL-9-ONE ALPHA CYCLOPIAZONIC ACID CPA CYCLOPIAZONIC ACID CYCLOPIAZONIC ACID, PENICILLIUM CYCLOPIUM CYCLOPIAZONIC ACID FROM PENICILLIUMCYCLO PIUM MINIM 9H-Pyrrolo1,2:2,3isoindolo4,5,6-cdindol-9-one, 10-acetyl-2,6,6a,7,11a,11b-hexahydro-11-hydroxy-7,7-dimethyl-, (6aR,11aS,11bR)-rel- CYCLOPIAZONICACID,BIOTECHGRADE [5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[3-hydroxy-2,2-dimethyl-3-[2-(2-octadeca-6,9,12-trienoylsulfanylethylcarbamoyl)ethylcarbamoyl]propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid gamma-linolenoyl-CoA Cyclopiazonic acid from Penicillium cyclopium PENICILLIUM CYCLOPIUM 10-Acetyl-2,6,6aβ,7,11aα,11bβ-hexahydro-11-hydroxy-7,7-dimethyl-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one Cyclopiazonic acid,98% Cyclopiazonic acid, 98%, from Penicillium griseofulvum Cyclopiazonic Acid, Penicillium cyclopium - CAS 18172-33-3 - Calbiochem Cyclopiazonic Acid, 98.0+ % (HPLC) Penicillium cyclopium Westling Penicillium cyclopiumPCR 9H-Pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one, 10-acetyl-2,6,6a,7,11a,11b-hexahydro-11-hydroxy-7,7-dimethyl-, (6aR,11aS,11bR)- 18172-33-3 181172-33-3 C20H20N2O3 C39H64N7O17P3S Intracellular Calcium Regulators Intracellular Calcium Signaling Cell Biology Cell Signaling and Neuroscience BioChemical antibiotic Signalling Calcium signaling