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CYCLOPIAZONIC ACID

CYCLOPIAZONIC ACID Structure
  • ₹8310 - ₹74411.05
  • Product name: CYCLOPIAZONIC ACID
  • CAS: 18172-33-3
  • MF: C20H20N2O3
  • MW: 336.38
  • EINECS:
  • MDL Number:MFCD00167445
  • Synonyms:-Cyclopiazonic acid / CPA;Cyclopiazonic acid from Penicillium grisefulvum;Cyclopiazonic acid (CPA);Cyclopiazonic acid, FroM PenicilliuM griseofulvuM;(6aR,11aS,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-2,6,6a,7,11a,11b-hexahydro-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one;Cyclopiazonic acid, 98%, from Penicillium griseofulvum;Cyclopiazonic Acid, Penicillium cyclopium - CAS 18172-33-3 - Calbiochem;(6a-alpha,11a,11b-alpha)--10-acetyl-7-dimethyl-11-hydroxy-
Price4 Properties Safety Information Description
4 prices
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Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 10MG
  • 50MG
  • ManufacturerSigma-Aldrich(India)
  • Product number239805
  • Product descriptionCyclopiazonic Acid, Penicillium cyclopium - CAS 18172-33-3 - Calbiochem A cell-permeable, reversible inhibitor of sarcoplasmic reticulum Ca2+-ATPase that releases Ca2+ from the same intracellular pools as Thapsigargin.
  • Packaging5MG
  • Price₹8310
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC1530
  • Product descriptionCyclopiazonic acid from Penicillium cyclopium ≥98% (HPLC), powder
  • Packaging5MG
  • Price₹12795.15
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC1530
  • Product descriptionCyclopiazonic acid from Penicillium cyclopium ≥98% (HPLC), powder
  • Packaging10MG
  • Price₹19874.7
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC1530
  • Product descriptionCyclopiazonic acid from Penicillium cyclopium ≥98% (HPLC), powder
  • Packaging50MG
  • Price₹74411.05
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 239805 Cyclopiazonic Acid, Penicillium cyclopium - CAS 18172-33-3 - Calbiochem A cell-permeable, reversible inhibitor of sarcoplasmic reticulum Ca2+-ATPase that releases Ca2+ from the same intracellular pools as Thapsigargin. 5MG ₹8310 2022-06-14 Buy
Sigma-Aldrich(India) C1530 Cyclopiazonic acid from Penicillium cyclopium ≥98% (HPLC), powder 5MG ₹12795.15 2022-06-14 Buy
Sigma-Aldrich(India) C1530 Cyclopiazonic acid from Penicillium cyclopium ≥98% (HPLC), powder 10MG ₹19874.7 2022-06-14 Buy
Sigma-Aldrich(India) C1530 Cyclopiazonic acid from Penicillium cyclopium ≥98% (HPLC), powder 50MG ₹74411.05 2022-06-14 Buy

Properties

Melting point :245-246°C
Boiling point :472.86°C (rough estimate)
Density :1.2171 (rough estimate)
refractive index :1.5700 (estimate)
storage temp. :-20°C
solubility :DMSO: soluble
form :powder
pka :4.50±1.00(Predicted)
color :white to off-white
Water Solubility :Soluble in DMSO (100 mM), ethanol (5 mM), DMF (~20 mg/ml), and 1:1 DMSO:PBS(pH 7.2) (0.5 mg/ml). Insoluble in water.
EPA Substance Registry System :Cyclopiazonic acid (18172-33-3)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H300 Fatal if swallowed Acute toxicity,oral Category 1, 2 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Description

Cyclopiazonic acid is a mycotoxin produced by molds including certain species of Penicillium and Aspergillus. Its toxicity is linked to its ability to specifically and reversibly inhibit sarco-endoplasmic reticulum Ca2+-ATPases (SERCA; IC50 = 0.6 μM). Cyclopiazonic acid does not inhibit a wide variety of other types of membrane-bound ATPases. It effectively inhibits SERCA in intact tissue, in smooth muscle and endothelium, as well as in isolated cells.

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