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5-chloro-3-hydroxyisothiazole

5-chloro-3-hydroxyisothiazole Structure
CAS No.
25629-58-7
Chemical Name:
5-chloro-3-hydroxyisothiazole
Synonyms
hydroxyisothiazole;5-chloroisothiazol-3-ol;5-Chloro-3-isothiazolol;5-chloroisothiazol-3-one;5-Chloroisothiazol-3(2H)-one;5-Chloro-3(2H)-isothiazolone;5-chloro-3-hydroxyisothiazole;5-Chloro-4-isothiazolin-3-one;3(2H)-Isothiazolone, 5-chloro-;5-chloro-3(2H)-Isothiazolone 97%
CBNumber:
CB92549513
Molecular Formula:
C3H2ClNOS
Molecular Weight:
135.57
MOL File:
25629-58-7.mol
Modify Date:
2023/10/19 9:55:33
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5-chloro-3-hydroxyisothiazole Properties

Melting point 96-97 °C(Solv: water (7732-18-5))
Density 1.62±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka 7.20±0.40(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H319-H335-H302+H312+H332-H315
Precautionary statements  P280-P301+P312-P302+P352
HS Code  2934100090

5-chloro-3-hydroxyisothiazole Chemical Properties,Uses,Production

Synthesis

5-chloro-3-hydroxyisothiazole can be synthesized from 3,3'-disulfanediyldipropionic acid and Thionyl chloride in three steps. In particular, in the last step, 5-chloro isothiazolone derivatives (5-chloro-3-hydroxyisothiazole) were the predominant products when the ratio of sulfuryl chloride/amide was 3:1 while with the relevant ratio of 1:1, the 5-unsubstituted analogs were the predominant products[1].5-chloro-3-hydroxyisothiazole

References

[1] Khalaj A, et al. Synthesis and antibacterial activity of 2-(4-substituted phenyl)-3(2H)-isothiazolones. European Journal of Medicinal Chemistry, 2004; 39: 285–290.

5-chloro-3-hydroxyisothiazole Preparation Products And Raw materials

Raw materials

3-[(3-AMINO-3-OXOPROPYL)DITHIO]PROPANAMIDE thiazol-3-one

Preparation Products

5-chloro-3-hydroxyisothiazole Suppliers

Global( 62)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Shanghai Boc Chemical Co., Ltd. 021-34975602; +8618721111801 China 138 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32835 60 Inquiry
Chengdu Aslee Biopharmaceuticals, Inc. 28-85305008 CHINA 964 58 Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30250 58 Inquiry
LEAPCHEM CO., LTD. +86-852-30606658 China 43348 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Suzhou ARTK Medchem Co., Ltd. +86-512-68323658 +86-18168183658 China 39010 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
Cool Pharm, Ltd 021-60455363 18019463053 China 12357 58 Inquiry
Supplier Advantage
A.J Chemicals 58
Shanghai Boc Chemical Co., Ltd. 58
ATK CHEMICAL COMPANY LIMITED 60
Chengdu Aslee Biopharmaceuticals, Inc. 58
Career Henan Chemica Co 58
LEAPCHEM CO., LTD. 58
Aladdin Scientific 58
Suzhou ARTK Medchem Co., Ltd. 58
Amadis Chemical Company Limited 58
Cool Pharm, Ltd 58
5-Chloro-3(2H)-isothiazolone 5-Chloro-3-isothiazolol 5-Chloro-4-isothiazolin-3-one 5-chloro-3(2H)-Isothiazolone 97% 5-chloro-3-hydroxyisothiazole 5-chloroisothiazol-3-ol 3(2H)-Isothiazolone, 5-chloro- 5-chloroisothiazol-3-one hydroxyisothiazole 5-Chloroisothiazol-3(2H)-one 25629-58-7 organic building block