ChemicalBook > Product Catalog >Pharmaceutical intermediates >Bulk Drug Intermediates >N-[(S)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester

N-[(S)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester

N-[(S)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester Structure
CAS No.
1334513-02-8
Chemical Name:
N-[(S)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester
Synonyms
SF-1.2;ATP-FTP-phoph;Sofosbuvir imp-75;Sofosbuvir-003-SS;SofosBuvir Impurity 15;Sofosbuvir InterMediates;Sofibuvir intermediate 1;Sofosbuvir Intermediate 5;Sofosbuvir side chain N-1;Sofosbuvir InterMediates4
CBNumber:
CB92604353
Molecular Formula:
C18H17F5NO5P
Molecular Weight:
453.3
MOL File:
1334513-02-8.mol
Modify Date:
2024/4/8 17:36:13

N-[(S)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester Properties

Melting point 133-135°C
Boiling point 442.6±55.0 °C(Predicted)
Density 1.405
vapor pressure 0Pa at 25℃
storage temp. 2-8°C
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka -3.81±0.70(Predicted)
form Solid
color White
LogP 4.1 at 30℃ and pH7.37

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P280-P305+P351+P338-P310
HS Code  2931599090

N-[(S)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester Chemical Properties,Uses,Production

Uses

N-[(S)-(2,3,4,5,6-Pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl Ester is a reactant in the synthesis of phosphoramidate imidazo[2,1-f][1,2,4]triazine-4-amine adenosine prodrugs that can increase anti-HCV activity.

N-[(S)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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1. (S)-isopropyl2-(((S)-(perfluorophenoxy)(phenoxy)phosphoryl) N-[(S)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester (SIDE CHAIN) L-Alanine, N-[(S)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-, 1-methylethyl ester propan-2-yl (2S)-2-{[(S)-pentafluorophenoxy(phenoxy)phosphoryl]amino}propanoate Sofosbuvir side chain N-1 Sofosbuvir Intermediate 5 isopropyl ((S)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alaninate N-[(S)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester (S)-isopropyl 2-(((S)-(perfluorophenoxy)(phenoxy)phosphoryl)aMino)propanoate Isopropyl N-[(pentafluorophenoxy)(phenoxy)phosphoryl]-L-alaninate Sofosbuvir InterMediates (2S)-isopropyl 2-(((perfluorophenoxy)(phenoxy)phosphoryl)aMino)propanoate SofosBuvir Impurity 15 2'-Defluro-2'-hydroxy 2'-epi-Sofosbuvir Isopropyl (2S)-2-[[(S)-(Perfluorophenoxy)(phenoxy)phosphoryl]amino]propionate Sofosbuvir InterMediates4 isopropyl ((S)-(perfluorophenoxy)(phenoxy)phosphoryl)-L-alanite ((2R,3R,4S,5R)-3-(benzoyloxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate Sofosbuvir imp-75 N-[(S)-(2,3,4,5,6-pentafluorophenoxy) phenoxyphosphatidyl ]- L- alanine isopropyl ester N-[(S)-(2,3,4,5, 6-pentafluorophenoxy) phenoxyphosphoacyl] -L-alanine isopropyl ester SF-1.2 propan-2-yl(2S)-2-[[(2,3,4,5,6-pentafluorophenoxy)-phenoxyphosphoryl]amino]propanoate Sofosbuvir-003-SS N-[(S)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester ISO 9001:2015 REACH ATP-FTP-phoph L-alanien,N-[(S)-(2,3,4,5,6-Pentafluorophenoxy)-phenoxy-phosphinyl]-1-Methylethylester 6-pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester Isopropyl N-[(pentafluorophenoxy)(phenoxy)phosphoryl]-L-alan... (R)-Sofosbuvir Pentafluorophenoxy AnalogueQ: What is (R)-Sofosbuvir Pentafluorophenoxy Analogue Q: What is the CAS Number of (R)-Sofosbuvir Pentafluorophenoxy Analogue Q: What is the storage condition of (R)-Sofosbuvir Pentafluorophenoxy Analogue Q: What are the applications of (R)-Sofosbuvir Pentafluorophenoxy Analogue (R)-Sofosbuvir Pentafluorophenoxy Analogue 8 N-[(S)-(2,3,4,5,6 pentafluorophenoxy) phenoxyphosphinyl]-L-alanine 1-Methylethyl ester N-[(S)-(2,3,4,5, 6-pentafluorophenoxy) phenoxyphosphoryl] -L-alanine isopropyl ester N - [(S) - (2,3,4,5,6-neneneba pentafluorophenyl oxy) phenoxyphosphoryl] - L-alanine isopropyl ester Isopropyl N-[(S)-(pentafluorophenoxy)(phenoxy)phosphoryl]-L-alaninate Sofibuvir intermediate 1 N-[(S)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl este (2S)-Isopropyl-2-((perfluorophexyl) (phenoxy)phosphorylamino Propanoate N-[ -(2,3,4,5,6-pentafluoro phenoxy)phenoxy phosphinyl]-L-alanine-1-methyl ethyl ester 1334513-02-8 C18H17F5NO5P Sofosbuvir intermediate Pharmaceuticalintermediates