ChemicalBook > Product Catalog >API >Antineoplastic agents >Natural sources of antineoplastic >Rubitecan
Rubitecan
- CAS No.
- 91421-42-0
- Chemical Name:
- Rubitecan
- Synonyms
- 9-NC;RFS 2000;Oratheci;orathecin;RUBITECAN;RUBETICAN;Rubitecane;9-NITRO-CPT;9-Nitrocamptothecin;Rubitecan USP/EP/BP
- CBNumber:
- CB9270138
- Molecular Formula:
- C20H15N3O6
- Molecular Weight:
- 393.35
- MOL File:
- 91421-42-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/18 11:31:14
| Melting point | 182-186°C |
|---|---|
| alpha | D23 +27° (c = 0.2 in CH3OH-CHCl3, 1:4) |
| Boiling point | 816.3±65.0 °C(Predicted) |
| Density | 1.63 |
| Flash point | 106℃ |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO, Chloroform, Methanol |
| form | Solid |
| pka | 11.16±0.20(Predicted) |
| color | Yellow |
| Merck | 14,8288 |
| CAS DataBase Reference | 91421-42-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Safety Statements | 24/25 |
|---|---|
| WGK Germany | 3 |
| RTECS | UQ0493300 |
| HS Code | 29399990 |
Rubitecan price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | R3655 | Rubitecan | 91421-42-0 | 10MG | ₹4243.4 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | R3655 | Rubitecan | 91421-42-0 | 50MG | ₹16843.7 | 2022-06-14 | Buy |
| TCI Chemicals (India) | N0822 | 9-Nitrocamptothecin | 91421-42-0 | 100MG | ₹13000 | 2022-05-26 | Buy |
Rubitecan Chemical Properties,Uses,Production
Description
Rubitecan is a DNA topoisomerase I inhibitor. It inhibits DNA topoisomerase I and increases the fraction of supercoiled DNA in a cell-free assay in a concentration-dependent manner. Rubitecan inhibits the growth of A121 ovarian and H460 lung cancer cells (IC50s = 4 and 2 nM, respectively). It also inhibits the growth of doxorubicin-susceptible and -resistant MCF-7 breast cancer cells (IC50s = 2 and 3 nM, respectively). Rubitecan (4 mg/kg twice per week) reduces tumor growth in a U937 leukemia mouse xenograft model.
Chemical Properties
Yellow Amorphous Powder
Definition
ChEBI: A pyranoindolizinoquinoline that is camptothecin in which the hydrogen at position 9 has been replaced by a nitro group. It is a prodrug for 9-aminocamptothecin.
Rubitecan Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 182)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29894 | 58 | Inquiry |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | CHINA | 1824 | 58 | Inquiry |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | China | 10312 | 58 | Inquiry |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | China | 3777 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| SIMAGCHEM CORP | +86-13806087780 | China | 17367 | 58 | Inquiry |
91421-42-0(Rubitecan)Related Search:
(+)-Camptothecin
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4-hydroxy-9-methoxy-, (4S)-
SN-38-D3
7-Ethyl-20(R)-camptothecin
daurisoline
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1of4
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9-Nitrocamptothecin (Rubitecan)
9-Nitrocamptothecin
RFS 2000
9-Nitrocellulose camptothecine
9-NITRO-CPT
9-NITRO-20(S)-CAMPTOTHECIN
(4s)-4-ethyl-4-hydroxy-10-nitro-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione
RUBETICAN
RUBITECAN
orathecin
CAMPTOTHECIN, 9-NITRO-20(S)-
Rubitecane
(4S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[346,7]indolizinol[1,2-b]quinoline-3, 14(4H,-12H)-dione
9-NC
Oratheci
Rubitecan (RFS 2000)
9-Nitrocamptothecin>
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-10-nitro-, (4S)-
Rubitecan USP/EP/BP
Camptothecin Impurity 13
CAMPTOTHECIN, 9-NITRO-20
(S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
91421-42-0
C20H15N3O6
Anti-cancer & immunity
API
Intermediates & Fine Chemicals
Pharmaceuticals