L-Hyoscyamine
- CAS No.
- 101-31-5
- Chemical Name:
- L-Hyoscyamine
- Synonyms
- HYOSCYAMINE;APOA;(-)-Hycosamine;AK38;L-(P);Levsin;SEPSECS;Levsinex;DATURINE;Cystospaz
- CBNumber:
- CB5772230
- Molecular Formula:
- C17H23NO3
- Molecular Weight:
- 289.37
- MOL File:
- 101-31-5.mol
- Modify Date:
- 2023/6/8 9:02:56
| Melting point | 108,5°C |
|---|---|
| alpha | D20 -21.0° (alc) |
| Boiling point | 431.53°C (rough estimate) |
| Density | 1.0470 (rough estimate) |
| refractive index | 1.5200 (estimate) |
| storage temp. | 2-8°C |
| solubility |
DMSO:79.0(Max Conc. mg/mL);273.0(Max Conc. mM) Ethanol:58.0(Max Conc. mg/mL);200.43(Max Conc. mM) |
| pka | pKa (21°) 9.7 |
| form | powder |
| color | white |
| Water Solubility | 3.6g/L(20 ºC) |
| Merck | 14,4858 |
| InChIKey | RKUNBYITZUJHSG-FXUDXRNXSA-N |
| LogP | 1.380 (est) |
| CAS DataBase Reference | 101-31-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Hyoscyamine(101-31-5) |
| EPA Substance Registry System | Benzeneacetic acid, .alpha.-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, (.alpha.S)- (101-31-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300+H330-H370 | |||||||||
| Precautionary statements | P260-P264-P270-P271-P284-P301+P310+P330-P304+P340+P310-P307+P311-P403+P233-P405-P501 | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 26/28 | |||||||||
| Safety Statements | 24-45 | |||||||||
| RIDADR | UN 1544 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NH0875000 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | I | |||||||||
| HS Code | 29339900 | |||||||||
| Toxicity | man,LDLo,unreported,1471ug/kg (1.471mg/kg),"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970. | |||||||||
| NFPA 704 |
|
L-Hyoscyamine price More Price(1)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | HPA070409 | Anti-SEPSECS antibody produced in rabbit Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody | 101-31-5 | 100μL | ₹41436.3 | 2022-06-14 | Buy |
| Product number | Packaging | Price | Buy |
|---|---|---|---|
| HPA070409 | 100μL | ₹41436.3 | Buy |
L-Hyoscyamine Chemical Properties,Uses,Production
Chemical Properties
White to Off-White Solid
Uses
L-Hyoscyamine can be used as anticholinergic and analgesic.
Definition
ChEBI: An atropine with a 2S-configuration.
General Description
Hyoscyamine is a levorotatory alkaloidobtained from various solanaceous species. One ofthe commercial sources is Egyptian henbane (Hyoscyamusmuticus), in which it occurs to the extent of about 0.5%.Usually, it is prepared from the crude drug in a manner similarto that used for atropine and is purified as the oxalate.The free base is obtained easily from this salt.
It occurs as white needles that are sparingly soluble inwater (1:281), more soluble in ether (1:69) or benzene(1:150), very soluble in chloroform (1:1), and freely solublein alcohol. It is used as the sulfate and hydrobromide. Theprincipal reason for the popularity of the hydrobromide hasbeen its nondeliquescent nature. The salts have the advantageover the free base in being quite water soluble.
Clinical Use
(L-Hyoscyamine)Hyoscyamine is used to treat disorders of the urinarytract more so than any other antispasmodic, although thereis no evidence that it has any advantages over the otherbelladonna preparations and the synthetic anticholinergics.It is used to treat spasms of the bladder and, in this manner,serves as a urinary stimulant. It is used together witha narcotic to counteract the spasm produced by the narcoticwhen the latter is used to relieve the pain of urethral colic.Hyoscyamine preparations are also used as antispasmodicsin the therapy of peptic ulcers.
L-Hyoscyamine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Anant Pharmaceuticals Pvt Ltd | +91-8550986868 +91-9485998001 | Haryana, India | 461 | 58 | Inquiry |
| Chempifine Chemicals | +91-2225667766 +91-2225667766 | Punjab, India | 144 | 58 | Inquiry |
| Orgamine Chemicals(I) Pvt Ltd | +91-9820080281 +91-9820080281 | Maharashtra, India | 451 | 58 | Inquiry |
| Anant Pharmaceuticals Pvt. ltd | +91 8550986868 | Maharashtra, India | 736 | 58 | Inquiry |
| ALCHEM INTERNATIONAL PRIVATE LIMITED | +91-11-26809882 | New Delhi, India | 15 | 58 | Inquiry |
| Anant Pharmaceuticals Pvt., Ltd. | 91-9324977784 | Maharashtra, India | 160 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
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