Atropine sulfate
- CAS No.
- 55-48-1
- Chemical Name:
- Atropine sulfate
- Synonyms
- ATROPINE SULPHATE;atropinsulfat;Ryuato;eyesule;corbella;atropisal;NSC 26671;davurtrop;atropette;Tropintran
- CBNumber:
- CB8315445
- Molecular Formula:
- 2C17H23NO3.H2O4S
- Molecular Weight:
- 676.82
- MOL File:
- 55-48-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/12/18 14:15:32
| Melting point | 189-192 °C (A)(lit.) |
|---|---|
| Boiling point | 135 °C |
| Density | 1.1172 (rough estimate) |
| refractive index | 1.6900 (estimate) |
| storage temp. | 0-6°C |
| solubility | Soluble in DMSO |
| form | Solid |
| color | Crystals |
| InChIKey | HOBWAPHTEJGALG-AADVZIIPNA-N |
| CAS DataBase Reference | 55-48-1(CAS DataBase Reference) |
| EPA Substance Registry System | Atropine sulfate (55-48-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H300-H330 |
| Precautionary statements | P260-P271-P284-P304+P340-P310-P320-P403+P233-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501 |
| Hazard Codes | T+ |
| Risk Statements | 26/28 |
| Safety Statements | 23-45 |
| RIDADR | UN 1544 6.1/PG 2 |
| WGK Germany | 2 |
| F | 3-8-10 |
| Toxicity | LD50 oral in rat: 600mg/kg |
Atropine sulfate Chemical Properties,Uses,Production
Uses
anticholinergic agent
General Description
Atropine sulfate (Atropisol)is prepared by neutralizing atropine in acetone or ethersolution with an alcoholic solution of sulfuric acid, withcare used to prevent hydrolysis. The salt occurs as colorlesscrystals or as a white, crystalline powder. It is efflorescentin dry air and should be protected from light to preventdecomposition.
Atropine sulfate is freely soluble in water (1:0.5), in alcohol(1:5, 1:2.5 at boiling point), and in glycerin (1:2.5).Aqueous solutions are not very stable, although solutionsmay be sterilized at 120°C (15 lb pressure) in an autoclave if the pH is kept below 6. Sterilization probably is besteffected by the use of aseptic techniques and a bacteriologicalfilter. It has been suggested that no more than a 30-daysupply of an aqueous solution should be made and that forsmall quantities the best procedure is to use hypodermictablets and sterile distilled water. Kondritzer andZvirblis have studied the kinetics of alkaline and protoncatalyzedhydrolyses of atropine in aqueous solution. Theregion of maximal stability lies between pH 3 and approximately5. They have also proposed an equation to predictthe half-life of atropine undergoing hydrolysis at constantpH and temperature.
Clinical Use
Atropine may be used to treat some types of arrhythmias. Itincreases the heart rate by blocking the effects of ACh on thevagus. In this context, it is used to treat certain reversible bradyarrhythmiasthat may accompany acute myocardial infarction.It is also used as an adjunct to anesthesia to protect againstbradycardia, hypotension, and even cardiac arrest induced bythe skeletal muscle relaxant succinylcholine chloride.
Another use for atropine sulfate emerged following thedevelopment of the organophosphates, which are potent inhibitorsof AChE. Atropine is a specific antidote to preventthe muscarinic effects of ACh accumulation, such as vomiting,abdominal cramps, diarrhea, salivation, sweating, bronchoconstriction,and excessive bronchial secretions. It isused intravenously but does not protect against respiratoryfailure caused by depression of the respiratory center andthe muscles of respiration.
Safety Profile
Poison by subcutaneous, intravenous, and intraperitoneal routes. Moderately toxic by ingestion. Human (child) pulmonary system effects by ingestion. Human systemic effects: decreased body temperature, cardiac arrhythmias. An experimental teratogen. Other experimental reproductive effects. See also ATROPINE. When heated to decomposition it emits very toxic fumes of NO,xand SOx.
Atropine sulfate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Medi Pharma Drug House | +919930911911 | Mumbai, India | 143 | 58 | Inquiry |
| Humble Healthcare Limited | +91-9720093000 +91-8006400378 | Uttar Pradesh, India | 140 | 58 | Inquiry |
| ASolution Pharmaceuticals Pvt Ltd | +91-9028098511 +91-9028098510 | Maharashtra, India | 15 | 58 | Inquiry |
| Saurav Chemicals Ltd | +91-1725054817 +91-1725054817 | Haryana, India | 20 | 58 | Inquiry |
| Alchem International Pvt Ltd | +91-1126809882 +91-1126809882 | New Delhi, India | 15 | 58 | Inquiry |
| Inga Pharmaceuticals | +91-2228202932 +91-2228202932 | Maharashtra, India | 38 | 58 | Inquiry |
| Flowchem Pharma Pvt Ltd | +91-9606036218 +91-9845055636 | Karnataka, India | 33 | 58 | Inquiry |
| AKASH PHARMA EXPORTS | +91-9388123451 +91-9846039283 | Kerela, India | 470 | 58 | Inquiry |
| Scientific OEM | +91-22- 2343 7546 / 2341 3094 | New Delhi, India | 1994 | 38 | Inquiry |
| ALPHA CHEMIKA | +91-22-22061123 +91-22-66382501 | Mumbai, India | 1679 | 43 | Inquiry |
| Supplier | Advantage |
|---|---|
| Medi Pharma Drug House | 58 |
| Humble Healthcare Limited | 58 |
| ASolution Pharmaceuticals Pvt Ltd | 58 |
| Saurav Chemicals Ltd | 58 |
| Alchem International Pvt Ltd | 58 |
| Inga Pharmaceuticals | 58 |
| Flowchem Pharma Pvt Ltd | 58 |
| AKASH PHARMA EXPORTS | 58 |
| Scientific OEM | 38 |
| ALPHA CHEMIKA | 43 |
Related articles
- Atropine Sulfate: Pharmacodynamics, Pharmacokinetics and Toxicity
- Atropine sulfate, an antimuscarinic agent, reduces heart rate and increases respiratory rate, with variable absorption, hepati....
- Sep 25，2024
55-48-1(Atropine sulfate)Related Search:
1of4
chevron_right