(3R,4S,5S,6R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxyMethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol

(3R,4S,5S,6R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxyMethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol Structure
CAS No.
1620758-34-0
Chemical Name:
(3R,4S,5S,6R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxyMethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol
Synonyms
Empagliflozin-5;Jardiance Impurity E;Empagliflozin impurity I;Empagliflozin Impurity 503;1,5-Dihydroxyempagliflozin;Empagliflozin Impurity A -D;(1R)-1,5-Dihydroxyempagliflozin;Empagliflozin 1,5 Dihydroxy Imp;Empagliflozin Opening Impurities;Empagliflozin 1,5-Dihydroxy Impurity
CBNumber:
CB92728619
Molecular Formula:
C23H29ClO8
Molecular Weight:
468.92
MOL File:
1620758-34-0.mol
Modify Date:
2024/3/28 20:12:32

(3R,4S,5S,6R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxyMethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol Properties

Boiling point 770.5±60.0 °C(Predicted)
Density 1.435±0.06 g/cm3(Predicted)
pka 13.25±0.20(Predicted)

(3R,4S,5S,6R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxyMethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol Chemical Properties,Uses,Production

Uses

(1R)-1,5,-Dihydroxyempagliflozin is an impurity of Empagliflozin (E521510) which is a novel, potent and selective SGLT-2 inhibitor, improves glycaemic control and features of metabolic syndrome in diabetic rats.

(3R,4S,5S,6R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxyMethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol Preparation Products And Raw materials

Raw materials

Preparation Products

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Empagliflozin impurity I Jardiance Impurity E Empagliflozin Impurity A -D (1R)-1,5-Dihydroxyempagliflozin (2S,3R,4R,5R)-1-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy) benzyl)phenyl)hexane-1,2,3,4,5,6-hexaol Empagliflozin 1,5-Dihydroxy Impurity Empagliflozin impurity 5/(1R)-1,5-Dihydroxy Empagliflozin/(2S,3R,4R,5R)-1-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy) benzyl)phenyl)hexane-1,2,3,4,5,6-hexaol Empagliflozin 1,5 Dihydroxy Imp Empagliflozin-5 Empagliflozin Opening Impurities D-Glucitol, 1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-, (1R)- (1R)-1-C-[4-Chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-D-glucitol Empagliflozin Open Ring ImpurityQ: What is Empagliflozin Open Ring Impurity Q: What is the CAS Number of Empagliflozin Open Ring Impurity Q: What is the storage condition of Empagliflozin Open Ring Impurity Q: What are the applications of Empagliflozin Open Ring Impurity Empagliflozin Impurity 503 (1R,2S,3R,4R,5R)-1-(4-Chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)hexane-1,2,3,4,5,6-hexaol (Empagliflozin Impurity) (1R,2S,3R,4R,5R)-1-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy) 1,5-Dihydroxyempagliflozin 1620758-34-0