S-23
- CAS No.
- 1010396-29-8
- Chemical Name:
- S-23
- Synonyms
- Sarms powder;S-23;S-23/S23;S23 Sarm;Sarms S23;S-23 Sarms;S23 powder;S23 S 23 S-23;S23-1 gram(46);S 23 (contraceptive)
- CBNumber:
- CB92743832
- Molecular Formula:
- C18H13ClF4N2O3
- Molecular Weight:
- 416.75
- MOL File:
- 1010396-29-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:41
| Melting point | 119-121 °C |
|---|---|
| Boiling point | 577.1±50.0 °C(Predicted) |
| Density | 1.48±0.1 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 12.04±0.29(Predicted) |
| form | Solid |
| color | White to Off-White |
| optical activity | [α]/D 20±3°, c = 0.1 in chloroform |
| BRN | 19161994 |
| InChI | InChI=1S/C18H13ClF4N2O3/c1-17(27,9-28-12-4-5-14(19)15(20)7-12)16(26)25-11-3-2-10(8-24)13(6-11)18(21,22)23/h2-7,27H,9H2,1H3,(H,25,26)/t17-/m0/s1 |
| InChIKey | SSFVOEAXHZGTRJ-KRWDZBQOSA-N |
| SMILES | C(NC1=CC=C(C#N)C(C(F)(F)F)=C1)(=O)[C@](O)(C)COC1=CC=C(Cl)C(F)=C1 |
S-23 Chemical Properties,Uses,Production
Description
S-23, the orally bioavailable nonsteroidal SARM, is appreciated by jocks over the world for its one of a kind capacity to improve fit bulk and bone tissue. A more secure option in contrast to anabolic steroid, this particular androgen receptor modulator is incredibly powerful to lose obstinate fat. Considered by numerous individuals as an amazing form of S-4 (Andarine), S-23 is a standout amongst other execution upgrading medications to solidify muscle and increase a grainier stylish look.
Uses
S 23 is a selective androgen receptor modulator.
benefits
Increments both skeletal and bulk
Advances durable bulk and perseverance gains
Perfect for muscle solidifying
Totally sets off catabolism in a calorie shortage
Builds bone quality and decreases fat mass
Improves drive in people
Encourages clients to hold increases long after a cycle
No swelling or liquid maintenance
Step by step instructions to Use S-23
Biological Activity
S-23 is a selective androgen receptor modulator (SARM). It binds to the AR (Ki = 1.7 nM) and induces AR-mediated transcriptional activation in CV-1 cells expressing the human receptor when used at a concentration of 10 nM. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats. It decreases testicular sperm concentration without reducing mounting behavior or the number of intromissions in intact rats when administered in combination with estradiol benzoate (Item No. 10006487). S-23 (3 mg/kg) also increases preference for sexually active intact males when administered to ovariectomized female rats.
Clinical Use
S-23 is an investigational selective androgen receptor modulator (SARM) developed by GTX, Inc as a potential male hormonal contraceptive. It binds to the androgen receptor more strongly than older drugs such as andarine with a Ki of 1.7 nM, and in animal studies it showed both a good ratio of anabolic to androgenic effects, and dose-dependent suppression of spermatogenesis with spontaneous recovery after cessation of treatment.
References
[1] JONES A, CHEN J, HWANG D J, et al. Preclinical characterization of a (S)-N-(4-cyano-3-trifluoromethyl-phenyl)-3-(3-fluoro, 4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide: a selective androgen receptor modulator for hormonal male contraception.[J]. Endocrinology, 2009, 150 1: 385-395. DOI:10.1210/en.2008-0674.
[2] JONES A, HWANG D J, DUKE C B, et al. Nonsteroidal Selective Androgen Receptor Modulators Enhance Female Sexual Motivation[J]. Journal of Pharmacology and Experimental Therapeutics, 2010, 334: 439-448. DOI:10.1124/jpet.110.168880.
S-23 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Homme Pharma | 08048250259Ext 923 | Mumbai, India | 4 | 58 | Inquiry |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | China | 616 | 58 | Inquiry |
| Changzhou Xuanming Pharmaceutical Technology Co., Ltd. | +86-519-85525359 +86-15995072465 | China | 906 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| Zhuzhou New Peptides Tech Co.,Ltd. | +86-18073326374 +86-18073326374 | China | 145 | 58 | Inquiry |
| Hebei Anlijie Biotechnology Co., Ltd | +8619031013551 | China | 145 | 58 | Inquiry |
| Wuhan Ruichi Technology Co., Ltd | +8613545065237 | China | 161 | 58 | Inquiry |
| Guangdong Tuoyuan Biotechnology Co., LTD | +85267545345 | China | 152 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | China | 12446 | 58 | Inquiry |
| Dorne Chemical Technology co. LTD | +86-86-13583358881 +8618560316533 | China | 3138 | 58 | Inquiry |