S-23

S-23 속성

S-23 C화학적 특성, 용도, 생산

개요

S-23, the orally bioavailable nonsteroidal SARM, is appreciated by jocks over the world for its one of a kind capacity to improve fit bulk and bone tissue. A more secure option in contrast to anabolic steroid, this particular androgen receptor modulator is incredibly powerful to lose obstinate fat. Considered by numerous individuals as an amazing form of S-4 (Andarine), S-23 is a standout amongst other execution upgrading medications to solidify muscle and increase a grainier stylish look.

용도

S 23 is a selective androgen receptor modulator.

benefits

Increments both skeletal and bulk
Advances durable bulk and perseverance gains
Perfect for muscle solidifying
Totally sets off catabolism in a calorie shortage
Builds bone quality and decreases fat mass
Improves drive in people
Encourages clients to hold increases long after a cycle
No swelling or liquid maintenance
Step by step instructions to Use S-23

생물학적 활성

S-23 is a selective androgen receptor modulator (SARM). It binds to the AR (Ki = 1.7 nM) and induces AR-mediated transcriptional activation in CV-1 cells expressing the human receptor when used at a concentration of 10 nM. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats. It decreases testicular sperm concentration without reducing mounting behavior or the number of intromissions in intact rats when administered in combination with estradiol benzoate (Item No. 10006487). S-23 (3 mg/kg) also increases preference for sexually active intact males when administered to ovariectomized female rats.

Clinical Use

S-23 is an investigational selective androgen receptor modulator (SARM) developed by GTX, Inc as a potential male hormonal contraceptive. It binds to the androgen receptor more strongly than older drugs such as andarine with a Ki of 1.7 nM, and in animal studies it showed both a good ratio of anabolic to androgenic effects, and dose-dependent suppression of spermatogenesis with spontaneous recovery after cessation of treatment.

참고 문헌

[1] JONES A, CHEN J, HWANG D J, et al. Preclinical characterization of a (S)-N-(4-cyano-3-trifluoromethyl-phenyl)-3-(3-fluoro, 4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide: a selective androgen receptor modulator for hormonal male contraception.[J]. Endocrinology, 2009, 150 1: 385-395. DOI:10.1210/en.2008-0674.
[2] JONES A, HWANG D J, DUKE C B, et al. Nonsteroidal Selective Androgen Receptor Modulators Enhance Female Sexual Motivation[J]. Journal of Pharmacology and Experimental Therapeutics, 2010, 334: 439-448. DOI:10.1124/jpet.110.168880.

S-23 준비 용품 및 원자재

원자재

준비 용품

S-23 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Changzhou Xuanming Pharmaceutical Technology Co., Ltd.	+8615995072465	sales@xuanmingchem.com	China	914	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
Hebei Anlijie Biotechnology Co., Ltd	+8619031013551	ably@aljbio.com	China	144	58
Wuhan Ruichi Technology Co., Ltd	+8613545065237	admin@whrchem.com	China	153	58
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12837	58
Dorne Chemical Technology co. LTD	+86-86-13583358881 +8618560316533	Ethan@dornechem.com	China	3105	58
Firsky International Trade (Wuhan) Co., Ltd	+8615387054039	admin@firsky-cn.com	China	427	58
qingdao future trading Co., Ltd	+86-13335044410 +86-13335044410	cui56813@163.com	China	110	58
Shandong Huisheng Import & Export Co., Ltd.	+86-13176845580 +86-13176845580	da@zhongda-biotech.com	China	232	58
Anhui Zhongda Biotechnology Co., Ltd	+8615689548120	linda@zhongda-biotech.com	China	193	58