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Bulleyaconitine A

CAS No.: 107668-79-1

Chemical Name:: Bulleyaconitine A

Synonyms: Bulleyaconitine;BULLEYACONITINE A;Bulleyaconi cine A;BULLEYACONITINE A(P);BULLEYACONITINE A(RG);Aconitane,Methanone deriv;Bulleyaconitine A USP/EP/BP;crassicauline A(bulleyaconitine;(-)-Syringaresinol 4-O-β-D-glucopyranosi;Methanone, [(1α,6α,14α,16β) -8-(acetyloxy)-

CBNumber:: CB9291737

Molecular Formula:: C35H49NO9

Molecular Weight:: 627.76

MOL File:: 107668-79-1.mol

MSDS File:: SDS

Modify Date:: 2024/7/2 8:55:41

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Bulleyaconitine A Properties

Boiling point	690.9±55.0 °C(Predicted)
Density	1.28±0.1 g/cm3(Predicted)
storage temp.	Store at 2-8°C
solubility	DMSO: 125 mg/mL (199.12 mM)
form	Solid
pka	13.12±0.70(Predicted)
color	White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H330-H300
Precautionary statements	P260-P271-P284-P304+P340-P310-P320-P403+P233-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501

Bulleyaconitine A Chemical Properties,Uses,Production

Description

Bulleyaconitine A is an aconitine-type two terpene alkaloid, and its molecular formula is C35H49NO10.?As early as 1980, bulleyaconitine was separated and extracted from a traditional analgesic and anti-inflammatory herb in the west of Yunnan called dianxi dula (or dianxi wutou) (Aconitum bulleyanum Diels), by the Kunming Institute of Botany, Chinese Academy of Sciences . At present, bulleyaconitine A can be separated from Aconitum plants, for example, dianxi wutou (Aconitum bulleyanum Diels), cujing wutou (Aconitum crassicaule W.T.?Wang), changhui wutou (Aconitum georgei Comber), and zhiyuan wutou (Aconitum transsectum Diels).

Physical properties

Appearance: white powder. Solubility: soluble in methanol, ethanol, chloroform, and ether; insoluble in water; and easily dissolved in dilute hydrochloric acid or dilute sulfuric acid . Melting point: 160–165?°C

History

In 1983, it was confirmed that bulleyaconitine A shows obvious analgesic and antiinflammatory effects by preclinical pharmacological tests . Clinical trials were carried out in 29 hospitals in 9 provinces in 1984. Bulleyaconitine A passed technical appraisals in May 1985 and was first formally put into production by Yunnan Honghe Pingbian pharmaceutical company, where it obtained the trade name “Bulleyaconitine A.” Bulleyaconitine A has been listed into the Pharmacopoeia of the People’s Republic of China (2015). In recent years, bulleyaconitine A has shown a great market growth and competitive power, owing to its exact curative effect and rapid clinical promotion in chronic disease and rheumatic immune disease.

Clinical Use

1. Rheumatic immune disease. Since listing, bulleyaconitine A has been applied in clinical treatment for rheumatoid arthritis and osteoarthritis, receiving good curative effects.
2. Chronic pain. Bulleyaconitine A does not belong to NSAID, and it exerts its effects by regulating the sodium ion channel. So there is little psychological dependence and organ toxicity, avoiding gastrointestinal/cardiovascular/renal adverse reactions and drug dependence or other potential dangers caused by NSAID and opioid analgesics.

Bulleyaconitine A Preparation Products And Raw materials

Raw materials

Preparation Products

Bulleyaconitine A Suppliers

Global( 196)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29899	58	Inquiry
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	China	3424	58	Inquiry
Xi'an Kono chem co., Ltd.,	029-86107037 13289246953	China	2995	58	Inquiry
Shaanxi Pioneer Biotech Co., Ltd .	+8613259417953	China	3000	58	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry
Neostar United (Changzhou) Industrial Co., Ltd.	+86-519-519-85557386	China	12177	58	Inquiry
Hubei Ipure Biology Co., Ltd	+8613367258412	China	10326	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	25910	58	Inquiry
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	China	9326	58	Inquiry

Supplier	Advantage
career henan chemical co	58
Chengdu Biopurify Phytochemicals Ltd.	58
Xi'an Kono chem co., Ltd.,	58
Shaanxi Pioneer Biotech Co., Ltd .	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
Hubei Ipure Biology Co., Ltd	58
Dideu Industries Group Limited	58
Baoji Guokang Bio-Technology Co., Ltd.	58

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16-trimethoxy-4-(methoxymethyl)aconitan-14-yl)(4-methoxyphenyl)-y-6 methanone,((1-alpha,6-alpha,14-alpha,16-beta)-8-(acetyloxy)-20-ethyl-13-hydrox BULLEYACONITINE A METHANONE, [(1,6,14,16)-8-(ACETYLOXY)-20-ETHYL-13-HYDROXY-1,6,16-TRIMETHOXY-4-(METHOXYMETHYL)ACONITAN-14-YL](4-METHOXYPHENYL)- BULLEYACONITINE A: METHANONE, [(1,6,14,16) -8-(ACETYLOXY)-20-ETHYL-13-HYDROXY-1,6,16-TRIMETHOXY-4-(METHOXYMETHYL)ACONITAN-14-YL](4-METHOXYPHENYL)-, BULLEYACONITINE A(P) 20-ethyl-13-hydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-yl](4-methoxyphenyl)- Methanone, [(1α,6α,14α,16β) -8-(acetyloxy)- Bulleyaconi cine A BULLEYACONITINE A(RG) Aconitane,Methanone deriv Methanone, [(1a,6a,14a,16b)-8-(acetyloxy)-20-ethyl-13-hydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-yl](4-methoxyphenyl)- Bulleyaconitine ((1-α,6-α,14-α,16-β)-8-(acetyloxy)-20-ethyl-13-hydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-yl)(4-methoxyphenyl)-methanone Bulleyaconitine A, 98%, from Aconitum kusnezoffii Rchb. crassicauline A(bulleyaconitine Methanone, [(1α,6α,14α,16β)-8-(acetyloxy)-20-ethyl-13-hydroxy-1,6,16-trimethoxy-4-(methoxymethyl) aconitan-14-yl](4-methoxyphenyl)- Bulleyaconitine A USP/EP/BP (-)-Syringaresinol 4-O-β-D-glucopyranosi 107668-79-1 79572-91-9 C35H49NO9 standardized herbal extract Inhibitors Natural Plant Extract chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM).