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Bulleyaconitine A

CAS No.: 107668-79-1

Chemical Name:: Bulleyaconitine A

Synonyms: Bulleyaconitine;BULLEYACONITINE A;Bulleyaconi cine A;BULLEYACONITINE A(P);Bulleyaconitine A-RM;BULLEYACONITINE A(RG);Aconitane,Methanone deriv;Bulleyaconitine A USP/EP/BP;crassicauline A(bulleyaconitine;Bulleyaconitine A, 10 mM in DMSO

CBNumber:: CB9291737

Molecular Formula:: C35H49NO9

Molecular Weight:: 627.76

MOL File:: 107668-79-1.mol

MSDS File:: SDS

Modify Date:: 2024/11/19 23:02:33

Request For Quotation

Bulleyaconitine A Properties

Boiling point	690.9±55.0 °C(Predicted)
Density	1.28±0.1 g/cm3(Predicted)
storage temp.	Store at 2-8°C
solubility	DMSO: 125 mg/mL (199.12 mM)
form	Solid
pka	13.12±0.70(Predicted)
color	White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H330-H300
Precautionary statements	P260-P271-P284-P304+P340-P310-P320-P403+P233-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501

Bulleyaconitine A Chemical Properties,Uses,Production

Description

Bulleyaconitine A is an aconitine-type two terpene alkaloid, and its molecular formula is C35H49NO10.?As early as 1980, bulleyaconitine was separated and extracted from a traditional analgesic and anti-inflammatory herb in the west of Yunnan called dianxi dula (or dianxi wutou) (Aconitum bulleyanum Diels), by the Kunming Institute of Botany, Chinese Academy of Sciences . At present, bulleyaconitine A can be separated from Aconitum plants, for example, dianxi wutou (Aconitum bulleyanum Diels), cujing wutou (Aconitum crassicaule W.T.?Wang), changhui wutou (Aconitum georgei Comber), and zhiyuan wutou (Aconitum transsectum Diels).

Physical properties

Appearance: white powder. Solubility: soluble in methanol, ethanol, chloroform, and ether; insoluble in water; and easily dissolved in dilute hydrochloric acid or dilute sulfuric acid . Melting point: 160–165?°C

History

In 1983, it was confirmed that bulleyaconitine A shows obvious analgesic and antiinflammatory effects by preclinical pharmacological tests . Clinical trials were carried out in 29 hospitals in 9 provinces in 1984. Bulleyaconitine A passed technical appraisals in May 1985 and was first formally put into production by Yunnan Honghe Pingbian pharmaceutical company, where it obtained the trade name “Bulleyaconitine A.” Bulleyaconitine A has been listed into the Pharmacopoeia of the People’s Republic of China (2015). In recent years, bulleyaconitine A has shown a great market growth and competitive power, owing to its exact curative effect and rapid clinical promotion in chronic disease and rheumatic immune disease.

Clinical Use

1. Rheumatic immune disease. Since listing, bulleyaconitine A has been applied in clinical treatment for rheumatoid arthritis and osteoarthritis, receiving good curative effects.
2. Chronic pain. Bulleyaconitine A does not belong to NSAID, and it exerts its effects by regulating the sodium ion channel. So there is little psychological dependence and organ toxicity, avoiding gastrointestinal/cardiovascular/renal adverse reactions and drug dependence or other potential dangers caused by NSAID and opioid analgesics.

Bulleyaconitine A Preparation Products And Raw materials

Raw materials

Preparation Products

Bulleyaconitine A Suppliers

Global( 204)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29858	58	Inquiry
Chengdu Biopurify Phytochemicals Ltd.	+86-28-82633860; +8618080483897	China	3772	58	Inquiry
BOC Sciences	+1-631-485-4226	United States	19552	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	32159	58	Inquiry
Hubei Ipure Biology Co., Ltd	+8613367258412	China	10244	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	22854	58	Inquiry
Baoji Guokang Bio-Technology Co., Ltd.	0917-3909592 13892490616	China	9304	58	Inquiry
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	China	52849	58	Inquiry
Alfa Chemistry		United States	24072	58	Inquiry
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418684 +8618949823763	China	25356	58	Inquiry

Supplier	Advantage
career henan chemical co	58
Chengdu Biopurify Phytochemicals Ltd.	58
BOC Sciences	58
TargetMol Chemicals Inc.	58
Hubei Ipure Biology Co., Ltd	58
Dideu Industries Group Limited	58
Baoji Guokang Bio-Technology Co., Ltd.	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Alfa Chemistry	58
Hefei TNJ Chemical Industry Co.,Ltd.	58

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16-trimethoxy-4-(methoxymethyl)aconitan-14-yl)(4-methoxyphenyl)-y-6 methanone,((1-alpha,6-alpha,14-alpha,16-beta)-8-(acetyloxy)-20-ethyl-13-hydrox BULLEYACONITINE A METHANONE, [(1,6,14,16)-8-(ACETYLOXY)-20-ETHYL-13-HYDROXY-1,6,16-TRIMETHOXY-4-(METHOXYMETHYL)ACONITAN-14-YL](4-METHOXYPHENYL)- BULLEYACONITINE A: METHANONE, [(1,6,14,16) -8-(ACETYLOXY)-20-ETHYL-13-HYDROXY-1,6,16-TRIMETHOXY-4-(METHOXYMETHYL)ACONITAN-14-YL](4-METHOXYPHENYL)-, BULLEYACONITINE A(P) 20-ethyl-13-hydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-yl](4-methoxyphenyl)- Methanone, [(1α,6α,14α,16β) -8-(acetyloxy)- Bulleyaconi cine A BULLEYACONITINE A(RG) Aconitane,Methanone deriv Methanone, [(1a,6a,14a,16b)-8-(acetyloxy)-20-ethyl-13-hydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-yl](4-methoxyphenyl)- Bulleyaconitine ((1-α,6-α,14-α,16-β)-8-(acetyloxy)-20-ethyl-13-hydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-yl)(4-methoxyphenyl)-methanone Bulleyaconitine A, 98%, from Aconitum kusnezoffii Rchb. crassicauline A(bulleyaconitine Methanone, [(1α,6α,14α,16β)-8-(acetyloxy)-20-ethyl-13-hydroxy-1,6,16-trimethoxy-4-(methoxymethyl) aconitan-14-yl](4-methoxyphenyl)- Bulleyaconitine A USP/EP/BP (-)-Syringaresinol 4-O-β-D-glucopyranosi Bulleyaconitine A-RM Bulleyaconitine A, 10 mM in DMSO 107668-79-1 79572-91-9 C35H49NO9 standardized herbal extract Inhibitors Natural Plant Extract chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM).