PROTAMINE
- CAS No.
- 9012-00-4
- Chemical Name:
- PROTAMINE
- Synonyms
- HSDB 3251;PROTAMINE;protamines;PROTAMINE USP/EP/BP;protamine from salmon;protamine free base grade iv;Protamine from salmon Grade IV, Histone, free(Millon test);(S)-7-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
- CBNumber:
- CB9468351
- Molecular Formula:
- Molecular Weight:
- 0
- MOL File:
- Mol file
- Modify Date:
- 2025/1/21 19:06:49
SAFETY
Risk and Safety Statements
| WGK Germany | 3 |
|---|---|
| RTECS | UK9440000 |
| Hazardous Substances Data | 9012-00-4(Hazardous Substances Data) |
PROTAMINE price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | P4005 | Protamine from salmon Grade IV, Histone, free(Millon test) | 9012-00-4 | 250MG | ₹10345.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P4005 | Protamine from salmon Grade IV, Histone, free(Millon test) | 9012-00-4 | 1G | ₹29658.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P4005 | Protamine from salmon Grade IV, Histone, free(Millon test) | 9012-00-4 | 5G | ₹85290.2 | 2022-06-14 | Buy |
PROTAMINE Chemical Properties,Uses,Production
Chemical Properties
Water soluble, producing basic solu- tions.
Uses
Protamine from salmon has been used to avoid in vitro AT complex formation in samples from dogs pre-treated with heparin. It has also been used to study the influences of external potential on adsorption of various proteins to a metal surface.
Definition
protamine: Any of a group of proteinsof relatively low molecularweight found in association with thechromosomal DNA of vertebratesperm cells. They contain a singlepolypeptide chain comprising about67% arginine. Protamines are thoughtto protect and support the chromosomes.
General Description
Protamines are proteins rich in cysteine and arginine. It possesses many phosphorylation sites. Salmon fish contains around 15 genes encoding protamine. It is found to be localized to the sperm head.
Mechanism of action
Protamine sulfate has been approved in the United States as a specific antagonist to heparin since 1968. Protamines are an arginine-rich, highly basic group of simple proteins derived from salmon sperm. The highly acidic heparin polysaccharides exhibit their anticoagulant activity through binding to antithrombin III. Because of the basicity of protamine, heparin has an increased affinity for protamine relative to antithrombin III. In fact, its binding affinity for protamine is so much greater than that of antithrombin III that protamine actually will induce dissociation of the heparin/antithrombin III complex. If protamine is administered in the absence of heparin, it can have marked effects on coagulation. Protamine is not completely selective for heparin and, in vivo, also interacts with fibrinogen, platelets, and other plasma proteins causing anticoagulation. For this reason, use of the minimal amount of protamine necessary to antagonize heparin-associated bleeding should be employed (usually 1 mg of protamine intravenously for every 100 U of heparin remaining in the patient).
Side effects
Anaphylaxis also has been associated with the use of protamine. Although development of protamine anaphylaxis is not limited to diabetics, those patients with diabetes that have used protaminecontaining insulin (NPH or protamine zinc) do have a slightly increased risk of anaphylaxis. Some less common reactions to protamine include pulmonary vasoconstriction, hypotension, and thrombus formation.
PROTAMINE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | China | 8806 | 58 | Inquiry |
| Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 | China | 12831 | 58 | Inquiry |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | China | 1287 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29810 | 58 | Inquiry |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | China | 10319 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | China | 34563 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 22787 | 58 | Inquiry |
| Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | CHINA | 9414 | 58 | Inquiry |
| Shijiazhuang Tongyang Import and Export Co., LTD | 18031361688; | China | 977 | 58 | Inquiry |
| PT CHEM GROUP LIMITED | +86-85511178; +86-85511178; | China | 35425 | 58 | Inquiry |