N-NITROSO-L-PROLINE
- CAS No.
- 7519-36-0
- Chemical Name:
- N-NITROSO-L-PROLINE
- Synonyms
- NPRO;no-pro;Nsc109545;nitrosoproline;1-Nitrosoproline;N-NITROSO-PROLINE;1-nitroso-l-proline;N-NITROSO-L-PROLINE;L-Proline, nitroso-;L-Proline, 1-nitroso-
- CBNumber:
- CB9489314
- Molecular Formula:
- C5H8N2O3
- Molecular Weight:
- 144.13
- MOL File:
- 7519-36-0.mol
- Modify Date:
- 2024/8/15 19:00:21
| Melting point | 108-109°C |
|---|---|
| Boiling point | 262.71°C (rough estimate) |
| Density | 1.4054 (rough estimate) |
| refractive index | 1.4472 (estimate) |
| storage temp. | -20°C Freezer |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Sparingly) |
| pka | 3.23±0.20(Predicted) |
| form | Solid |
| color | Pale Yellow to Brown |
| IARC | 3 (Vol. 17, Sup 7) 1987 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H319-H302-H334-H351-H341-H315-H312-H335 |
| Precautionary statements | P261-P285-P304+P341-P342+P311-P501-P201-P202-P281-P308+P313-P405-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P-P280-P302+P352-P312-P322-P363-P501-P201-P202-P281-P308+P313-P405-P501-P264-P270-P301+P312-P330-P501 |
| Toxicity | LD50 ipr-mus: 203 mg/kg JMCMAR 16,583,73 |
N-NITROSO-L-PROLINE Chemical Properties,Uses,Production
Chemical Properties
Colourless Plates
Uses
A nitrosoamino acid with oncogenicity. The LD50 of a single ip dose given to Swiss-Webster mice is 203 +/- 22 mg / kg
Production Methods
There is no indication that nitrosoproline was made commercially. It has been reported in cured meats (e.g., bacon) at concentrations of 340–440 μg/kg. Both higher and lower levels in several cured products have been reported by several authors.
Safety Profile
Poison by intraperitoneal route.Questionable carcinogen with experimental tumorigenicdata. Many nitroso compounds are carcinogens. Whenheated to decomposition it emits toxic fumes of NOx. Seealso NITROSO COMPOUNDS.
Carcinogenicity
Mice were given 0.1% NPRO in drinking water for 26 weeks, and no more lung adenomas were seen than in untreated controls at 38 weeks, showing a lack of carcinogenicity. In rats, higher doses (0.145%) in drinking water for 2 years showed no tumors that were not seen in untreated controls (174). IARC classified NPRO as not classifiable as to carcinogenicity to humans (Group 3).
N-NITROSO-L-PROLINE Preparation Products And Raw materials
Raw materials
Preparation Products
N-NITROSO-L-PROLINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| ANAXLABORATORIES PRIVATE LIMITED | +91-9177075735 | Telangana, India | 686 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 | China | 3883 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29808 | 58 | Inquiry |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | China | 52849 | 58 | Inquiry |
| sgtlifesciences pvt ltd | +8617013299288 | China | 12373 | 58 | Inquiry |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | China | 49984 | 58 | Inquiry |
| Hubei Qingbei Yunyan Pharmaceutical Technology Co., Ltd | 18162595016; 18162595016 | China | 9122 | 58 | Inquiry |
| Hubei Xinyang Medical Technology Co., Ltd | 15347293736 15347293736 | China | 9137 | 58 | Inquiry |
| Nanjing bojida Pharmaceutical Technology Co., Ltd | 18762407961 | China | 939 | 58 | Inquiry |