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9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE

9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE Structure
CAS No.
3519-82-2
Chemical Name:
9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE
Synonyms
INCA-6;Nsc25996;NFAT Activation Inhibitor III;INCA-6 NFAT Activation Inhibitor III;9,10-[1,2]benzenoanthracene-13,16(9H,10H)-dione;9,10-[1,2]Benzeno-9,10-dihydro-1,4-anthraquinone;9,10-Dihydro-9,10-[1,2]benzeno-1,4-anthraquinone;9,10-[1,2]Benzeno-9,10-dihydroanthracene-1,4-dione;9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE;9,10[1',2']-Benzenoanthracene-1,4-dione, 9,10-dihydro-
CBNumber:
CB9839254
Molecular Formula:
C20H12O2
Molecular Weight:
284.31
MOL File:
3519-82-2.mol
Modify Date:
2024/7/2 8:55:42
Request For Quotation

9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE Properties

storage temp. Store at RT
solubility Soluble in DMSO
form Yellow solid
color Light yellow to yellow

9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 480403 NFAT Activation Inhibitor III - CAS 3519-82-2 - Calbiochem The NFAT Activation Inhibitor III, also referenced under CAS 3519-82-2, controls the biological activity of NFAT. This small molecule/inhibitor is pri 3519-82-2 5MG ₹17860 2022-06-14 Buy
Product number Packaging Price Buy
480403 5MG ₹17860 Buy

9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE Chemical Properties,Uses,Production

Description

NFAT activation inhibitor III is a cell-permeant inhibitor of signaling through nuclear factor of activated T cells (NFAT). It binds the substrate recognition site of the phosphatase calcineurin (Kd = 0.8 μM), preventing it from binding and dephosphorylating NFAT. NFAT activation inhibitor III blocks the nuclear import of NFAT in T cells stimulated with ionomycin . It prevents the induced expression of cytokine mRNAs in T cells stimulated with phorbol ester and ionomycin.

Uses

INCA 6 inhibits nuclear factor of activated T cells (NFAT) dephosphorylation and nuclear import, which in turn, interferes with downstream targets of NFAT including induction of cytokine mRNAs.

General Description

A cell-permeable, potent, and selective inhibitor of Calcineurin-NFAT (Nuclear Factor of Activated T cells) signaling. Binds to calcineurin with high affinity (Kd = 800 nM), disrupts its interaction with NFAT, and completely blocks calcineurin-dependent NFAT dephosphorylation, nuclear import (~40 μM in C1.7W2 T cells), and induction of NFAT-targeted cytokine mRNAs. Unlike CsA (Cat. No. 239835) and FK506, INCA-6 does not affect calcineurin activity or its downstream signaling.

Biological Activity

Inhibitor of interaction between calcineurin and its substrate nuclear factor of activated T cells (NFAT); blocks at the substrate recognition site but not at the catalytic site (K d = 0.8 mM). Inhibits NFAT dephosphorylation and nuclear import. Also prevents induction of cytokine mRNAs that are downstream targets of NFAT.

9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE Preparation Products And Raw materials

Raw materials

Preparation Products

9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE Suppliers

Global( 37)Suppliers
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Aladdin Scientific +1-+1(833)-552-7181 United States 52927 58 Inquiry
RD International Technology Co., Limited 18024082417 China 9274 58 Inquiry
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 China 4551 58 Inquiry
BIOTREND Chemicals AG +41 44 805 76 76 Germany 1250 62 Inquiry
Service Chemical Inc. 888-895-6920 Germany 6373 71 Inquiry
3B Scientific Corporation 847.281.9822 United States 6744 47 Inquiry
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 China 15848 69 Inquiry
Spectrum Chemical Manufacturing Corp. 021-021-021-67601398-809-809-809 15221380277 China 9664 60 Inquiry
Shanghai TenSus Biotechnology Co., Ltd. 021-50895067 18616507272 China 4207 58 Inquiry
Tocris Bioscience +44 (0) 117 916 3333 United Kingdom 5729 77 Inquiry
Supplier Advantage
Aladdin Scientific 58
RD International Technology Co., Limited 58
Nantong QuanYi Biotechnology Co., Ltd 58
BIOTREND Chemicals AG 62
Service Chemical Inc. 71
3B Scientific Corporation 47
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Spectrum Chemical Manufacturing Corp. 60
Shanghai TenSus Biotechnology Co., Ltd. 58
Tocris Bioscience 77

9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE Spectrum

9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE(3519-82-2)1HNMR

3519-82-2(9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE)Related Search:

9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE RARECHEM AQ BC 8A49 2,3-dimethyl-2,5-cyclohexadiene-1,4 dione 4,4-DIPHENYL-2-BUTANONE p-Toluquinone
1,4,9,10-Tetrahydro-9,10-[1,2]benzenoanthracene-1,4-dione 9,10-[1,2]Benzeno-1,4,9,10-tetrahydroanthracene-1,4-dione 9,10-[1,2]Benzeno-9,10-dihydro-1,4-anthraquinone 9,10-[1,2]Benzeno-9,10-dihydroanthracene-1,4-dione 9,10-Dihydro-9,10-[1,2]benzeno-1,4-anthraquinone Nsc25996 NFAT Activation Inhibitor III INCA-6 9,10-DIHYDRO-9,10[1',2']-BENZENOANTHRACENE-1,4-DIONE INCA-6 NFAT Activation Inhibitor III 9,10-[1,2]benzenoanthracene-13,16(9H,10H)-dione 9,10[1',2']-Benzenoanthracene-1,4-dione, 9,10-dihydro- factors,inhibit,INCA-6,NFAT,microvascular,INCA 6,transcription,endothelial,Inhibitor,retinopathy,oxygen-induced,INCA6,retinal,neovascularization 3519-82-2 C20H12O2 Protein Phosphatase