ChemicalBook > Product Catalog >Pharmaceutical intermediates >Heterocyclic compound >7-chloro-1H-indole-2-carboxylic acid
7-chloro-1H-indole-2-carboxylic acid
- CAS No.
- 28899-75-4
- Chemical Name:
- 7-chloro-1H-indole-2-carboxylic acid
- Synonyms
- 7-Chloroindole-2-carboxylic acid;1H-Indole-2-carboxylic acid, 7-chloro-;7-chloro-1H-indole-2-carboxylic acid(SALTDATA: FREE)
- CBNumber:
- CB9895577
- Molecular Formula:
- C9H6ClNO2
- Molecular Weight:
- 195.6
- MOL File:
- 28899-75-4.mol
- Modify Date:
- 2024/1/30 10:21:20
| Boiling point | 449.7±25.0 °C(Predicted) |
|---|---|
| Density | 1.548±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 4.23±0.30(Predicted) |
| InChI | InChI=1S/C9H6ClNO2/c10-6-3-1-2-5-4-7(9(12)13)11-8(5)6/h1-4,11H,(H,12,13) |
| InChIKey | NVKAHBFPKVINGE-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=CC=C2Cl)C=C1C(O)=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335-H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
| HazardClass | IRRITANT |
| HS Code | 2933998090 |
7-chloro-1H-indole-2-carboxylic acid Chemical Properties,Uses,Production
Uses
7-chloro-1H-indole-2-carboxylic acid is an important pharmaceutical intermediate compound used in the preparation of protease inhibitors.
Synthesis
A mixture of 111.5 g of 7-chloroindole-2-carboxylate in 31.25 g of 96percent sodium hydroxide in 183 ml of methanol and 183 ml of water were heated under reflux for 1 hour, cooled to 45 ° C, and 10 percent hydrochloric acid was added dropwise to a pH of 3 to 4. The mixture was sufficiently cooled to obtain 89.7 g of product as an off-white 7-chloro-1H-indole-2-carboxylic acid.
7-chloro-1H-indole-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 81)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| VGS SYNTHESIS PRIVATE LIMITED | +91-9866975588 +91-9866975588 | Hyderabad, India | 1818 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| SHANDONG OUCHEM CO.,LTD. | +86-18506360988 +86-18506360988 | China | 48 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29798 | 60 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32835 | 60 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49403 | 58 | Inquiry |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | China | 8836 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30250 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | China | 34571 | 58 | Inquiry |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | China | 14350 | 58 | Inquiry |
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7-chloro-1H-indole-2-carboxylic acid(SALTDATA: FREE)
7-Chloroindole-2-carboxylic acid
1H-Indole-2-carboxylic acid, 7-chloro-
28899-75-4