Adipotide 化学特性,用途語,生産方法
安全性
A daily subcutaneous injection of Adipotide (0.43 mg/kg) is the optimal therapeutic dose for spontaneously obese macaques. It was demonstrated that the dosage of Adipotide is strongly correlated with body surface area and that its relative dose migrates from smaller to larger mammalian species (including humans). And animal studies show that Adipotide treatment is generally well tolerated. The major side effect is nephrotoxicity, which is generally mild and reversible. Decreases in serum phosphorus and potassium and urinary changes, including mild to marked glucosuria, mild to moderate proteinuria, and slight to mild increases in transitional/renal epithelial cells, have been noted throughout the dosing interval.
参考文献
[1] Kirstin F Barnhart. “A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys.” Science Translational Medicine 3 108 (2011): 108ra112.
Adipotide 上流と下流の製品情報
原材料
準備製品